Abstract
Originalsprog | Engelsk |
---|---|
Tidsskrift | Nature Genetics |
Vol/bind | 56 |
Udgave nummer | 2 |
Sider (fra-til) | 222–233 |
ISSN | 1061-4036 |
DOI | |
Status | Udgivet - 2024 |
Bibliografisk note
Publisher Copyright:© 2024, The Author(s).
Citationsformater
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference. / Meng, Xiangrui; Navoly, Georgina; Giannakopoulou, Olga; Levey, Daniel F.; Koller, Dora; Pathak, Gita A.; Koen, Nastassja; Lin, Kuang; Adams, Mark J.; Rentería, Miguel E.; Feng, Yanzhe; Gaziano, J. Michael; Stein, Dan J.; Zar, Heather J.; Campbell, Megan L.; van Heel, David A.; Trivedi, Bhavi; Finer, Sarah; McQuillin, Andrew; Bass, Nick; Chundru, V. Kartik; Martin, Hilary C.; Huang, Qin Qin; Valkovskaya, Maria; Chu, Chia Yi; Kanjira, Susan; Kuo, Po Hsiu; Chen, Hsi Chung; Tsai, Shih Jen; Liu, Yu Li; Kendler, Kenneth S.; Peterson, Roseann E.; Cai, Na; Fang, Yu; Sen, Srijan; Scott, Laura J.; Burmeister, Margit; Loos, Ruth J.F.; Preuss, Michael H.; Actkins, Ky’Era E.V.; Davis, Lea K.; Uddin, Monica; Wani, Agaz H.; Wildman, Derek E.; Aiello, Allison E.; Ursano, Robert J.; Kessler, Ronald C.; Kanai, Masahiro; Okada, Yukinori; Sakaue, Saori; Rabinowitz, Jill A.; Maher, Brion S.; Uhl, George; Eaton, William; Cruz-Fuentes, Carlos S.; Martinez-Levy, Gabriela A.; Campos, Adrian I.; Millwood, Iona Y.; Chen, Zhengming; Li, Liming; Wassertheil-Smoller, Sylvia; Jiang, Yunxuan; Tian, Chao; Martin, Nicholas G.; Mitchell, Brittany L.; Byrne, Enda M.; Awasthi, Swapnil; Coleman, Jonathan R.I.; Ripke, Stephan; Sofer, Tamar; Walters, Robin G.; McIntosh, Andrew M.; Polimanti, Renato; Dunn, Erin C.; Stein, Murray B.; Gelernter, Joel; Lewis, Cathryn M.; Kuchenbaecker, Karoline.
I: Nature Genetics, Bind 56, Nr. 2, 2024, s. 222–233.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
}
TY - JOUR
T1 - Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference
AU - Meng, Xiangrui
AU - Navoly, Georgina
AU - Giannakopoulou, Olga
AU - Levey, Daniel F.
AU - Koller, Dora
AU - Pathak, Gita A.
AU - Koen, Nastassja
AU - Lin, Kuang
AU - Adams, Mark J.
AU - Rentería, Miguel E.
AU - Feng, Yanzhe
AU - Gaziano, J. Michael
AU - Stein, Dan J.
AU - Zar, Heather J.
AU - Campbell, Megan L.
AU - van Heel, David A.
AU - Trivedi, Bhavi
AU - Finer, Sarah
AU - McQuillin, Andrew
AU - Bass, Nick
AU - Chundru, V. Kartik
AU - Martin, Hilary C.
AU - Huang, Qin Qin
AU - Valkovskaya, Maria
AU - Chu, Chia Yi
AU - Kanjira, Susan
AU - Kuo, Po Hsiu
AU - Chen, Hsi Chung
AU - Tsai, Shih Jen
AU - Liu, Yu Li
AU - Kendler, Kenneth S.
AU - Peterson, Roseann E.
AU - Cai, Na
AU - Fang, Yu
AU - Sen, Srijan
AU - Scott, Laura J.
AU - Burmeister, Margit
AU - Loos, Ruth J.F.
AU - Preuss, Michael H.
AU - Actkins, Ky’Era E.V.
AU - Davis, Lea K.
AU - Uddin, Monica
AU - Wani, Agaz H.
AU - Wildman, Derek E.
AU - Aiello, Allison E.
AU - Ursano, Robert J.
AU - Kessler, Ronald C.
AU - Kanai, Masahiro
AU - Okada, Yukinori
AU - Sakaue, Saori
AU - Rabinowitz, Jill A.
AU - Maher, Brion S.
AU - Uhl, George
AU - Eaton, William
AU - Cruz-Fuentes, Carlos S.
AU - Martinez-Levy, Gabriela A.
AU - Campos, Adrian I.
AU - Millwood, Iona Y.
AU - Chen, Zhengming
AU - Li, Liming
AU - Wassertheil-Smoller, Sylvia
AU - Jiang, Yunxuan
AU - Tian, Chao
AU - Martin, Nicholas G.
AU - Mitchell, Brittany L.
AU - Byrne, Enda M.
AU - Awasthi, Swapnil
AU - Coleman, Jonathan R.I.
AU - Ripke, Stephan
AU - Sofer, Tamar
AU - Walters, Robin G.
AU - McIntosh, Andrew M.
AU - Polimanti, Renato
AU - Dunn, Erin C.
AU - Stein, Murray B.
AU - Gelernter, Joel
AU - Lewis, Cathryn M.
AU - Kuchenbaecker, Karoline
N1 - Publisher Copyright: © 2024, The Author(s).
PY - 2024
Y1 - 2024
N2 - Most genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD, adding data from 21 cohorts with 88,316 MD cases and 902,757 controls to previously reported data. This analysis used a range of measures to define MD and included samples of African (36% of effective sample size), East Asian (26%) and South Asian (6%) ancestry and Hispanic/Latin American participants (32%). The multi-ancestry GWAS identified 53 significantly associated novel loci. For loci from GWAS in European ancestry samples, fewer than expected were transferable to other ancestry groups. Fine mapping benefited from additional sample diversity. A transcriptome-wide association study identified 205 significantly associated novel genes. These findings suggest that, for MD, increasing ancestral and global diversity in genetic studies may be particularly important to ensure discovery of core genes and inform about transferability of findings.
AB - Most genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD, adding data from 21 cohorts with 88,316 MD cases and 902,757 controls to previously reported data. This analysis used a range of measures to define MD and included samples of African (36% of effective sample size), East Asian (26%) and South Asian (6%) ancestry and Hispanic/Latin American participants (32%). The multi-ancestry GWAS identified 53 significantly associated novel loci. For loci from GWAS in European ancestry samples, fewer than expected were transferable to other ancestry groups. Fine mapping benefited from additional sample diversity. A transcriptome-wide association study identified 205 significantly associated novel genes. These findings suggest that, for MD, increasing ancestral and global diversity in genetic studies may be particularly important to ensure discovery of core genes and inform about transferability of findings.
U2 - 10.1038/s41588-023-01596-4
DO - 10.1038/s41588-023-01596-4
M3 - Journal article
C2 - 38177345
AN - SCOPUS:85181441322
VL - 56
SP - 222
EP - 233
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 2
ER -