TY - JOUR
T1 - Multi-drug-resistant tuberculosis in HIV positive patients in Eastern Europe
AU - Post, Frank A
AU - Grint, Daniel
AU - Efsen, Anne Marie Werlinrud
AU - Panteleev, Alexander
AU - Riekstina, Vieja
AU - Malashenkov, Evgeniy A
AU - Skrahina, Alena
AU - Duiculescu, Dan
AU - Podlekareva, Daria
AU - Karpov, Igor
AU - Bondarenko, Vasiliy
AU - Chentsova, Nelly
AU - Lundgren, Jens
AU - Mocroft, Amanda
AU - Kirk, Ole
AU - Miro, Jose M
AU - HIV-TB Study Group
N1 - Copyright © 2013 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
PY - 2014/3
Y1 - 2014/3
N2 - Observational data from Eastern Europe on the management and outcome of multi-drug-resistant tuberculosis (MDR TB) in HIV positive populations remain sparse in the English-language literature.We compared clinical characteristics and outcomes of 55 patients who were diagnosed with HIV and MDR TB in Eastern Europe between 2004 and 2006 to 89 patients whose Mycobacterium tuberculosis isolates were susceptible to isoniazid and rifampicin.Patients with HIV and MDR TB were young and predominantly male with high rates of intravenous drug use, imprisonment and hepatitis C co-infection. Eighty-four per cent of patients with MDR TB had no history of previous TB drug exposure suggesting that the majority of MDR TB resulted from transmission of drug-resistant M. tuberculosis. The use of non-standardized tuberculosis treatment was common, and the use of antiretroviral therapy infrequent. Compared to those with susceptible tuberculosis, patients with MDR TB were less likely to achieve cure or complete tuberculosis treatment (21.8% vs. 62.9%, p
AB - Observational data from Eastern Europe on the management and outcome of multi-drug-resistant tuberculosis (MDR TB) in HIV positive populations remain sparse in the English-language literature.We compared clinical characteristics and outcomes of 55 patients who were diagnosed with HIV and MDR TB in Eastern Europe between 2004 and 2006 to 89 patients whose Mycobacterium tuberculosis isolates were susceptible to isoniazid and rifampicin.Patients with HIV and MDR TB were young and predominantly male with high rates of intravenous drug use, imprisonment and hepatitis C co-infection. Eighty-four per cent of patients with MDR TB had no history of previous TB drug exposure suggesting that the majority of MDR TB resulted from transmission of drug-resistant M. tuberculosis. The use of non-standardized tuberculosis treatment was common, and the use of antiretroviral therapy infrequent. Compared to those with susceptible tuberculosis, patients with MDR TB were less likely to achieve cure or complete tuberculosis treatment (21.8% vs. 62.9%, p
UR - http://www.scopus.com/inward/record.url?scp=84894062806&partnerID=8YFLogxK
U2 - 10.1016/j.jinf.2013.09.034
DO - 10.1016/j.jinf.2013.09.034
M3 - Journal article
C2 - 24247067
AN - SCOPUS:84894062806
VL - 68
SP - 259
EP - 263
JO - Journal of Infection
JF - Journal of Infection
SN - 0163-4453
IS - 3
ER -