Multinational study in children and adolescents with newly diagnosed type 1 diabetes: association of age, ketoacidosis, HLA status, and autoantibodies on residual beta-cell function and glycemic control 12 months after diagnosis

Bidragets oversatte titel: Multinational study in children and adolescents with newly diagnosed type 1 diabetes: association of age, ketoacidosis, HLA status, and autoantibodies on residual beta-cell function and glycemic control 12 months after diagnosis

H.B. Mortensen, P.G.F. Swift, R.W. Holl, P. Hougaard, L. Hansen, H. Bjoerndalen, C.E. de Beaufort, M. Knip

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    117 Citationer (Scopus)

    Abstract

    Objective: To identify predictors of residual beta-cell function and glycemic control during the first 12 months after the diagnosis of type 1 diabetes (T1D). Subjects and Methods: Clinical information and blood samples were collected from 275 children. HbA1c, antibodies, HLA typing and mixed meal-stimulated C-peptide levels 1, 6, and 12 months after diagnosis were analyzed centrally. Results: Mean age at diagnosis was 9.1 yr. DKA with standard bicarbonate <15 mmol/L was associated with significantly poorer residual beta-cell function 1 (p = 0.004) and 12 months (p = 0.0003) after diagnosis. At 12 months, the decline in stimulated C-peptide levels compared with the levels at 1 month was 69% in the youngest age group and 50% in patients 10 yr and above (p <0.001). Stimulated C-peptide at 12 months was predicted by younger age (p <0.02) and bicarbonate levels at diagnosis (p = 0.005), and by stimulated C-peptide (p <0.0001), postmeal blood glucose (p = 0.0004), insulin antibodies (IA; p = 0.02) and glutamic acid decarboxylase antibodies (GADA; p = 0.0004) at 1 month. HbA1c at 12 months was predicted by HbA1c at diagnosis (p <0.0001), GADA at 1 month (p = 0.01), and non-white Caucasian ethnicity (p = 0.002). Conclusions: Younger age, ketoacidosis at diagnosis, and IA and GADA 1 month after diagnosis were the strongest explanatory factors for residual beta-cell function at 12 months. Glycemic control at 12 months was influenced predominantly by ethnicity, HbA1c at diagnosis, and GADA at 1 month
    Bidragets oversatte titelMultinational study in children and adolescents with newly diagnosed type 1 diabetes: association of age, ketoacidosis, HLA status, and autoantibodies on residual beta-cell function and glycemic control 12 months after diagnosis
    OriginalsprogEngelsk
    TidsskriftPediatric Diabetes
    Vol/bind11
    Udgave nummer4
    Sider (fra-til)218-226
    Antal sider9
    ISSN1399-543X
    StatusUdgivet - 2010

    Citationsformater