Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system

Torben Lykke Sørensen; Corinna Trebst; Pia Kivisäkk; Karen L Klaege; Amit Majmudar; Rivka Ravid; Hans Lassmann; David B Olsen; Robert M Strieter; Richard M Ransohoff; Finn Sellebjerg

Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system

Torben Lykke Sørensen, Corinna Trebst, Pia Kivisäkk, Karen L Klaege, Amit Majmudar, Rivka Ravid, Hans Lassmann, David B Olsen, Robert M Strieter, Richard M Ransohoff, Finn Sellebjerg

IKM

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning

230 Citationer (Scopus)

Abstract

T-cell accumulation in the central nervous system (CNS) is considered crucial to the pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the cerebrospinal fluid (CSF) compartment expressed the CXC chemokine receptor 3 (CXCR), independent of CNS inflammation. Quantitative immunohistochemistry revealed continuous accumulation of CXCR3+ T cells during MS lesion formation. The expression of one CXCR3 ligand, interferon (IFN)-gamma-inducible protein of 10 kDa (IP-10)/CXC chemokine ligand (CXCL) 10 was elevated in MS CSF, spatially associated with demyelination in CNS tissue sections and correlated tightly with CXCR3 expression. These data suggest a critical role for CXCL10 and CXCR3 in the accumulation of T cells in the CNS of MS patients.

Originalsprog	Engelsk
Tidsskrift	Journal of Neuroimmunology
Vol/bind	127
Udgave nummer	1-2
Sider (fra-til)	59-68
Antal sider	10
ISSN	0165-5728
Status	Udgivet - jun. 2002

Citationsformater

Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system. / Sørensen, Torben Lykke; Trebst, Corinna; Kivisäkk, Pia; Klaege, Karen L; Majmudar, Amit; Ravid, Rivka; Lassmann, Hans; Olsen, David B; Strieter, Robert M; Ransohoff, Richard M; Sellebjerg, Finn.

I: Journal of Neuroimmunology, Bind 127, Nr. 1-2, 06.2002, s. 59-68.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning

Sørensen, Torben Lykke ; Trebst, Corinna ; Kivisäkk, Pia ; Klaege, Karen L ; Majmudar, Amit ; Ravid, Rivka ; Lassmann, Hans ; Olsen, David B ; Strieter, Robert M ; Ransohoff, Richard M ; Sellebjerg, Finn. / Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system. I: Journal of Neuroimmunology. 2002 ; Bind 127, Nr. 1-2. s. 59-68.

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title = "Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system",

abstract = "T-cell accumulation in the central nervous system (CNS) is considered crucial to the pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the cerebrospinal fluid (CSF) compartment expressed the CXC chemokine receptor 3 (CXCR), independent of CNS inflammation. Quantitative immunohistochemistry revealed continuous accumulation of CXCR3+ T cells during MS lesion formation. The expression of one CXCR3 ligand, interferon (IFN)-gamma-inducible protein of 10 kDa (IP-10)/CXC chemokine ligand (CXCL) 10 was elevated in MS CSF, spatially associated with demyelination in CNS tissue sections and correlated tightly with CXCR3 expression. These data suggest a critical role for CXCL10 and CXCR3 in the accumulation of T cells in the CNS of MS patients.",

keywords = "Adult, Aged, Astrocytes, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Central Nervous System, Cerebrospinal Fluid, Chemokine CXCL10, Chemokines, CXC, Female, Flow Cytometry, Humans, Male, Middle Aged, Multiple Sclerosis, Myelitis, Transverse, Optic Neuritis, Receptors, CXCR3, Receptors, Chemokine",

author = "S{\o}rensen, {Torben Lykke} and Corinna Trebst and Pia Kivis{\"a}kk and Klaege, {Karen L} and Amit Majmudar and Rivka Ravid and Hans Lassmann and Olsen, {David B} and Strieter, {Robert M} and Ransohoff, {Richard M} and Finn Sellebjerg",

year = "2002",

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language = "English",

volume = "127",

pages = "59--68",

journal = "Journal of Neuroimmunology",

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TY - JOUR

T1 - Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system

AU - Sørensen, Torben Lykke

AU - Trebst, Corinna

AU - Kivisäkk, Pia

AU - Klaege, Karen L

AU - Majmudar, Amit

AU - Ravid, Rivka

AU - Lassmann, Hans

AU - Olsen, David B

AU - Strieter, Robert M

AU - Ransohoff, Richard M

AU - Sellebjerg, Finn

PY - 2002/6

Y1 - 2002/6

N2 - T-cell accumulation in the central nervous system (CNS) is considered crucial to the pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the cerebrospinal fluid (CSF) compartment expressed the CXC chemokine receptor 3 (CXCR), independent of CNS inflammation. Quantitative immunohistochemistry revealed continuous accumulation of CXCR3+ T cells during MS lesion formation. The expression of one CXCR3 ligand, interferon (IFN)-gamma-inducible protein of 10 kDa (IP-10)/CXC chemokine ligand (CXCL) 10 was elevated in MS CSF, spatially associated with demyelination in CNS tissue sections and correlated tightly with CXCR3 expression. These data suggest a critical role for CXCL10 and CXCR3 in the accumulation of T cells in the CNS of MS patients.

AB - T-cell accumulation in the central nervous system (CNS) is considered crucial to the pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the cerebrospinal fluid (CSF) compartment expressed the CXC chemokine receptor 3 (CXCR), independent of CNS inflammation. Quantitative immunohistochemistry revealed continuous accumulation of CXCR3+ T cells during MS lesion formation. The expression of one CXCR3 ligand, interferon (IFN)-gamma-inducible protein of 10 kDa (IP-10)/CXC chemokine ligand (CXCL) 10 was elevated in MS CSF, spatially associated with demyelination in CNS tissue sections and correlated tightly with CXCR3 expression. These data suggest a critical role for CXCL10 and CXCR3 in the accumulation of T cells in the CNS of MS patients.

KW - Adult

KW - Aged

KW - Astrocytes

KW - CD4-Positive T-Lymphocytes

KW - CD8-Positive T-Lymphocytes

KW - Central Nervous System

KW - Cerebrospinal Fluid

KW - Chemokine CXCL10

KW - Chemokines, CXC

KW - Female

KW - Flow Cytometry

KW - Humans

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis

KW - Myelitis, Transverse

KW - Optic Neuritis

KW - Receptors, CXCR3

KW - Receptors, Chemokine

M3 - Journal article

C2 - 12044976

VL - 127

SP - 59

EP - 68

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1-2

ER -