Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Pflügers Archiv: European Journal of Physiology |
| Vol/bind | 446 |
| Udgave nummer | 1 |
| Sider (fra-til) | 9-16 |
| Antal sider | 7 |
| ISSN | 0031-6768 |
| DOI | |
| Status | Udgivet - 2003 |
Bibliografisk note
Keywords: Animals; Anti-Inflammatory Agents; Exercise; Glucose; Glycogen; Humans; Insulin Resistance; Interleukin-6; Lipolysis; Muscle Contraction; Muscle, Skeletal; Signal Transduction; Tumor Necrosis Factor-alphaAdgang til dokumentet
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I: Pflügers Archiv: European Journal of Physiology, Bind 446, Nr. 1, 2003, s. 9-16.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Muscle-derived interleukin-6: lipolytic, anti-inflammatory and immune regulatory effects.
AU - Pedersen, Bente Klarlund
AU - Steensberg, Adam
AU - Keller, Pernille
AU - Keller, Charlotte
AU - Fischer, Christian
AU - Hiscock, Natalie
AU - van Hall, Gerrit
AU - Plomgaard, Peter
AU - Febbraio, Mark A
N1 - Keywords: Animals; Anti-Inflammatory Agents; Exercise; Glucose; Glycogen; Humans; Insulin Resistance; Interleukin-6; Lipolysis; Muscle Contraction; Muscle, Skeletal; Signal Transduction; Tumor Necrosis Factor-alpha
PY - 2003
Y1 - 2003
N2 - Interleukin-6 (IL-6) is produced locally in working skeletal muscle and can account for the exercise-induced increase in plasma IL-6. The transcription rate for IL-6 in muscle nuclei isolated from muscle biopsies during exercise is very high and is enhanced further when muscle glycogen content is low. Furthermore, cultured human primary muscle cells can increase IL-6 mRNA when incubated with the calcium ionophore ionomycin and it is likely that myocytes produce IL-6 in response to muscle contraction. The biological roles of muscle-derived IL-6 have been investigated in studies in which human recombinant IL-6 was infused in healthy volunteers to mimic closely the IL-6 concentrations observed during prolonged exercise. Using stable isotopes, we have demonstrated that physiological concentrations of IL-6 induce lipolysis. Although we have yet to determine the precise biological action of muscle-derived IL-6, our data support the hypothesis that the role of IL-6 released from contracting muscle during exercise is to act in a hormone-like manner to mobilize extracellular substrates and/or augment substrate delivery during exercise. In addition, IL-6 inhibits low-level TNF-alpha production, and IL-6 produced during exercise probably inhibits TNF-alpha-induced insulin resistance in peripheral tissues. Hence, IL-6 produced by skeletal muscle during contraction may play an important role in the beneficial health effects of exercise
AB - Interleukin-6 (IL-6) is produced locally in working skeletal muscle and can account for the exercise-induced increase in plasma IL-6. The transcription rate for IL-6 in muscle nuclei isolated from muscle biopsies during exercise is very high and is enhanced further when muscle glycogen content is low. Furthermore, cultured human primary muscle cells can increase IL-6 mRNA when incubated with the calcium ionophore ionomycin and it is likely that myocytes produce IL-6 in response to muscle contraction. The biological roles of muscle-derived IL-6 have been investigated in studies in which human recombinant IL-6 was infused in healthy volunteers to mimic closely the IL-6 concentrations observed during prolonged exercise. Using stable isotopes, we have demonstrated that physiological concentrations of IL-6 induce lipolysis. Although we have yet to determine the precise biological action of muscle-derived IL-6, our data support the hypothesis that the role of IL-6 released from contracting muscle during exercise is to act in a hormone-like manner to mobilize extracellular substrates and/or augment substrate delivery during exercise. In addition, IL-6 inhibits low-level TNF-alpha production, and IL-6 produced during exercise probably inhibits TNF-alpha-induced insulin resistance in peripheral tissues. Hence, IL-6 produced by skeletal muscle during contraction may play an important role in the beneficial health effects of exercise
U2 - 10.1007/s00424-002-0981-z
DO - 10.1007/s00424-002-0981-z
M3 - Journal article
C2 - 12690457
SN - 0031-6768
VL - 446
SP - 9
EP - 16
JO - Pflügers Archiv: European Journal of Physiology
JF - Pflügers Archiv: European Journal of Physiology
IS - 1
ER -