Mutations in the dihydropteroate synthase gene of Pneumocystis jiroveci isolates from Portuguese patients with Pneumocystis pneumonia

M C Costa; J Helweg-Larsen; Bettina Lundgren; F Antunes; O Matos

Mutations in the dihydropteroate synthase gene of Pneumocystis jiroveci isolates from Portuguese patients with Pneumocystis pneumonia

M C Costa, J Helweg-Larsen, Bettina Lundgren, F Antunes, O Matos

Institut for Klinisk Medicin

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

26 Citationer (Scopus)

Abstract

Udgivelsesdato: 2003-Nov

Originalsprog	Engelsk
Tidsskrift	International Journal of Antimicrobial Agents
Vol/bind	22
Udgave nummer	5
Sider (fra-til)	516-20
Antal sider	4
ISSN	0924-8579
Status	Udgivet - 2003

Citationsformater

Mutations in the dihydropteroate synthase gene of Pneumocystis jiroveci isolates from Portuguese patients with Pneumocystis pneumonia. / Costa, M C; Helweg-Larsen, J; Lundgren, Bettina; Antunes, F; Matos, O.

I: International Journal of Antimicrobial Agents, Bind 22, Nr. 5, 2003, s. 516-20.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

@article{364bce77fe674a2b8bb606e5cfd8212d,

title = "Mutations in the dihydropteroate synthase gene of Pneumocystis jiroveci isolates from Portuguese patients with Pneumocystis pneumonia",

abstract = "The aim of this study was to evaluate the frequency of mutations of the P. jiroveci dihydropteroate synthase (DHPS) gene in an immunocompromised Portuguese population and to investigate the possible association between DHPS mutations and sulpha exposure. In the studied population, DHPS gene mutations were not significantly more frequent in patients exposed to sulpha drugs compared with patients not exposed (P=0.390). The results of this study suggest that DHPS gene mutations are frequent in the Portuguese immunocompromised population but do not seem associated with previous sulpha exposure. These results are consistent with the possibility of an incidental acquisition and transmission of P. jiroveci mutant types, either by person to person transmission or from an environmental source.",

author = "Costa, {M C} and J Helweg-Larsen and Bettina Lundgren and F Antunes and O Matos",

year = "2003",

language = "English",

volume = "22",

pages = "516--20",

journal = "International Journal of Antimicrobial Agents",

issn = "0924-8579",

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TY - JOUR

T1 - Mutations in the dihydropteroate synthase gene of Pneumocystis jiroveci isolates from Portuguese patients with Pneumocystis pneumonia

AU - Costa, M C

AU - Helweg-Larsen, J

AU - Lundgren, Bettina

AU - Antunes, F

AU - Matos, O

PY - 2003

Y1 - 2003

N2 - The aim of this study was to evaluate the frequency of mutations of the P. jiroveci dihydropteroate synthase (DHPS) gene in an immunocompromised Portuguese population and to investigate the possible association between DHPS mutations and sulpha exposure. In the studied population, DHPS gene mutations were not significantly more frequent in patients exposed to sulpha drugs compared with patients not exposed (P=0.390). The results of this study suggest that DHPS gene mutations are frequent in the Portuguese immunocompromised population but do not seem associated with previous sulpha exposure. These results are consistent with the possibility of an incidental acquisition and transmission of P. jiroveci mutant types, either by person to person transmission or from an environmental source.

AB - The aim of this study was to evaluate the frequency of mutations of the P. jiroveci dihydropteroate synthase (DHPS) gene in an immunocompromised Portuguese population and to investigate the possible association between DHPS mutations and sulpha exposure. In the studied population, DHPS gene mutations were not significantly more frequent in patients exposed to sulpha drugs compared with patients not exposed (P=0.390). The results of this study suggest that DHPS gene mutations are frequent in the Portuguese immunocompromised population but do not seem associated with previous sulpha exposure. These results are consistent with the possibility of an incidental acquisition and transmission of P. jiroveci mutant types, either by person to person transmission or from an environmental source.

M3 - Journal article

VL - 22

SP - 516

EP - 520

JO - International Journal of Antimicrobial Agents

JF - International Journal of Antimicrobial Agents

SN - 0924-8579

IS - 5

ER -