Neoantigen reactive T cells correlate with the low mutational burden in hematological malignancies

Sunil Kumar Saini; Staffan Holmberg-Thydén; Anne Mette Bjerregaard; Ashwin Unnikrishnan; Simon Dorfmüller; Uwe Platzbecker; Irene Tirado-Gonzalez; Halvard Bönig; Daniel El Fassi; Kirsten Grønbæk; John Pimanda; Hind Medyouf; Sine Reker Hadrup

doi:10.1038/s41375-022-01705-y

Neoantigen reactive T cells correlate with the low mutational burden in hematological malignancies

Sunil Kumar Saini, Staffan Holmberg-Thydén, Anne Mette Bjerregaard, Ashwin Unnikrishnan, Simon Dorfmüller, Uwe Platzbecker, Irene Tirado-Gonzalez, Halvard Bönig, Daniel El Fassi, Kirsten Grønbæk, John Pimanda, Hind Medyouf, Sine Reker Hadrup^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Letter › peer review

3 Citationer (Scopus)

21 Downloads (Pure)

Originalsprog	Engelsk
Tidsskrift	Leukemia
Vol/bind	36
Udgave nummer	11
Sider (fra-til)	2734-2738
Antal sider	5
ISSN	0887-6924
DOI	https://doi.org/10.1038/s41375-022-01705-y
Status	Udgivet - 2022

Bibliografisk note

Funding Information:
We thank all patients and healthy donors for contributing to the analyzed samples. We thank all collaborators for their active participation in this work, specifically Bente Rotbøl, Anna Gyllenberg Burkal, and Anni Flarup Løye for excellent technical support. This work was supported by grants from the European Research Council (StG 677268 NextDART to SRH), the Lundbeck Foundation (R190-2014-4178 to SRH, and R181-2014-3828 to SKS), and the Van Andel Research Institute through the Van Andel Research Institute—Stand Up to Cancer Epigenetics Dream Team (to SRH, KG, and SKS). Stand Up to Cancer is a division of the Entertainment Industry Foundation, administered by AACR.

Funding Information:
We thank all patients and healthy donors for contributing to the analyzed samples. We thank all collaborators for their active participation in this work, specifically Bente Rotbøl, Anna Gyllenberg Burkal, and Anni Flarup Løye for excellent technical support. This work was supported by grants from the European Research Council (StG 677268 NextDART to SRH), the Lundbeck Foundation (R190-2014-4178 to SRH, and R181-2014-3828 to SKS), and the Van Andel Research Institute through the Van Andel Research Institute—Stand Up to Cancer Epigenetics Dream Team (to SRH, KG, and SKS). Stand Up to Cancer is a division of the Entertainment Industry Foundation, administered by AACR.

Adgang til dokumentet

10.1038/s41375-022-01705-yLicens: CC BY

FulltextForlagets udgivne version, 1,43 MBLicens: CC BY

Citationsformater

Saini, S. K., Holmberg-Thydén, S., Bjerregaard, A. M., Unnikrishnan, A., Dorfmüller, S., Platzbecker, U., Tirado-Gonzalez, I., Bönig, H., El Fassi, D., Grønbæk, K., Pimanda, J., Medyouf, H., & Hadrup, S. R. (2022). Neoantigen reactive T cells correlate with the low mutational burden in hematological malignancies. Leukemia, 36(11), 2734-2738. https://doi.org/10.1038/s41375-022-01705-y

Saini, SK, Holmberg-Thydén, S, Bjerregaard, AM, Unnikrishnan, A, Dorfmüller, S, Platzbecker, U, Tirado-Gonzalez, I, Bönig, H, El Fassi, D , Grønbæk, K, Pimanda, J, Medyouf, H & Hadrup, SR 2022, 'Neoantigen reactive T cells correlate with the low mutational burden in hematological malignancies', Leukemia, bind 36, nr. 11, s. 2734-2738. https://doi.org/10.1038/s41375-022-01705-y

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title = "Neoantigen reactive T cells correlate with the low mutational burden in hematological malignancies",

author = "Saini, {Sunil Kumar} and Staffan Holmberg-Thyd{\'e}n and Bjerregaard, {Anne Mette} and Ashwin Unnikrishnan and Simon Dorfm{\"u}ller and Uwe Platzbecker and Irene Tirado-Gonzalez and Halvard B{\"o}nig and {El Fassi}, Daniel and Kirsten Gr{\o}nb{\ae}k and John Pimanda and Hind Medyouf and Hadrup, {Sine Reker}",

note = "Funding Information: We thank all patients and healthy donors for contributing to the analyzed samples. We thank all collaborators for their active participation in this work, specifically Bente Rotb{\o}l, Anna Gyllenberg Burkal, and Anni Flarup L{\o}ye for excellent technical support. This work was supported by grants from the European Research Council (StG 677268 NextDART to SRH), the Lundbeck Foundation (R190-2014-4178 to SRH, and R181-2014-3828 to SKS), and the Van Andel Research Institute through the Van Andel Research Institute—Stand Up to Cancer Epigenetics Dream Team (to SRH, KG, and SKS). Stand Up to Cancer is a division of the Entertainment Industry Foundation, administered by AACR. Funding Information: We thank all patients and healthy donors for contributing to the analyzed samples. We thank all collaborators for their active participation in this work, specifically Bente Rotb{\o}l, Anna Gyllenberg Burkal, and Anni Flarup L{\o}ye for excellent technical support. This work was supported by grants from the European Research Council (StG 677268 NextDART to SRH), the Lundbeck Foundation (R190-2014-4178 to SRH, and R181-2014-3828 to SKS), and the Van Andel Research Institute through the Van Andel Research Institute—Stand Up to Cancer Epigenetics Dream Team (to SRH, KG, and SKS). Stand Up to Cancer is a division of the Entertainment Industry Foundation, administered by AACR.",

year = "2022",

doi = "10.1038/s41375-022-01705-y",

language = "English",

volume = "36",

pages = "2734--2738",

journal = "Leukemia",

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T1 - Neoantigen reactive T cells correlate with the low mutational burden in hematological malignancies

AU - Saini, Sunil Kumar

AU - Holmberg-Thydén, Staffan

AU - Bjerregaard, Anne Mette

AU - Unnikrishnan, Ashwin

AU - Dorfmüller, Simon

AU - Platzbecker, Uwe

AU - Tirado-Gonzalez, Irene

AU - Bönig, Halvard

AU - El Fassi, Daniel

AU - Grønbæk, Kirsten

AU - Pimanda, John

AU - Medyouf, Hind

AU - Hadrup, Sine Reker

N1 - Funding Information: We thank all patients and healthy donors for contributing to the analyzed samples. We thank all collaborators for their active participation in this work, specifically Bente Rotbøl, Anna Gyllenberg Burkal, and Anni Flarup Løye for excellent technical support. This work was supported by grants from the European Research Council (StG 677268 NextDART to SRH), the Lundbeck Foundation (R190-2014-4178 to SRH, and R181-2014-3828 to SKS), and the Van Andel Research Institute through the Van Andel Research Institute—Stand Up to Cancer Epigenetics Dream Team (to SRH, KG, and SKS). Stand Up to Cancer is a division of the Entertainment Industry Foundation, administered by AACR. Funding Information: We thank all patients and healthy donors for contributing to the analyzed samples. We thank all collaborators for their active participation in this work, specifically Bente Rotbøl, Anna Gyllenberg Burkal, and Anni Flarup Løye for excellent technical support. This work was supported by grants from the European Research Council (StG 677268 NextDART to SRH), the Lundbeck Foundation (R190-2014-4178 to SRH, and R181-2014-3828 to SKS), and the Van Andel Research Institute through the Van Andel Research Institute—Stand Up to Cancer Epigenetics Dream Team (to SRH, KG, and SKS). Stand Up to Cancer is a division of the Entertainment Industry Foundation, administered by AACR.

PY - 2022

Y1 - 2022

U2 - 10.1038/s41375-022-01705-y

DO - 10.1038/s41375-022-01705-y

M3 - Letter

C2 - 36209321

AN - SCOPUS:85139671910

SN - 0887-6924

VL - 36

SP - 2734

EP - 2738

JO - Leukemia

JF - Leukemia

IS - 11

ER -