TY - JOUR
T1 - Neurobiological effects of work-related stress
T2 - protocol for a case-control neuroimaging study
AU - Madsen, Saga Steinmann
AU - Gjedde, Albert
AU - Brandt, Lars
AU - Pihl-Thingvad, Jesper
AU - Videbech, Poul
AU - Gerke, Oke
AU - Højlund-Carlsen, Poul Flemming
N1 - Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
PY - 2018
Y1 - 2018
N2 - INTRODUCTION: Stress is one of the greatest burdens of our society and often implies impairments in cognitive and emotional functions. Here, we hypothesise that changes in the brain's dopamine (DA)-based mesocorticolimbic projec-tions in patients with work-related stress (adjustment disorder) will manifest themselves as altered glucose metabolism in relation to neural activity, and as altered DA radiotracer binding potentials at the relevant receptors.METHODS: Subjects and healthy controls undergo neuropsychiatric tests and PET/MRI with three tracers: 18F-fluorodeoxyglucose to measure glucose metabolism as a marker of neural activity, 11C-raclopride to explore binding potentials in the striatum, and 11C-FLB 457 to study possibly impaired mesocortical dopaminergic transmission in the cortex. To demonstrate differences of glucose metabolism, more than 2 × 41 patients/controls are needed. We expect to find that symptoms of cognitive and motivational reward deficits are attributable to changes in the frontal lobe and striatal glucose metabolism in the majority of patients, and that changes of D2-receptor availability and impaired dopaminergic transmission in the striatum and prefrontal cortex are contributing factors.CONCLUSIONS: This project is designed to generate entirely new and objective evidence of stress-induced cerebral illness, and to provide a basis for in-depth research and for a more rational management of this strenuous disorder.FUNDING: Private, industrial and public funds.TRIAL REGISTRATION: Clinicaltrails.gov/NCT03334045.
AB - INTRODUCTION: Stress is one of the greatest burdens of our society and often implies impairments in cognitive and emotional functions. Here, we hypothesise that changes in the brain's dopamine (DA)-based mesocorticolimbic projec-tions in patients with work-related stress (adjustment disorder) will manifest themselves as altered glucose metabolism in relation to neural activity, and as altered DA radiotracer binding potentials at the relevant receptors.METHODS: Subjects and healthy controls undergo neuropsychiatric tests and PET/MRI with three tracers: 18F-fluorodeoxyglucose to measure glucose metabolism as a marker of neural activity, 11C-raclopride to explore binding potentials in the striatum, and 11C-FLB 457 to study possibly impaired mesocortical dopaminergic transmission in the cortex. To demonstrate differences of glucose metabolism, more than 2 × 41 patients/controls are needed. We expect to find that symptoms of cognitive and motivational reward deficits are attributable to changes in the frontal lobe and striatal glucose metabolism in the majority of patients, and that changes of D2-receptor availability and impaired dopaminergic transmission in the striatum and prefrontal cortex are contributing factors.CONCLUSIONS: This project is designed to generate entirely new and objective evidence of stress-induced cerebral illness, and to provide a basis for in-depth research and for a more rational management of this strenuous disorder.FUNDING: Private, industrial and public funds.TRIAL REGISTRATION: Clinicaltrails.gov/NCT03334045.
KW - Case-Control Studies
KW - Corpus Striatum/diagnostic imaging
KW - Female
KW - Fluorodeoxyglucose F18
KW - Frontal Lobe/diagnostic imaging
KW - Glucose/metabolism
KW - Humans
KW - Magnetic Resonance Imaging/methods
KW - Male
KW - Neuroimaging/methods
KW - Occupational Stress/diagnostic imaging
KW - Positron-Emission Tomography/methods
KW - Prefrontal Cortex/diagnostic imaging
KW - Pyrrolidines
KW - Raclopride
KW - Radiopharmaceuticals
KW - Research Design
KW - Salicylamides
KW - Synaptic Transmission/drug effects
U2 - http://ugeskriftet.dk/dmj/neurobiological-effects-work-related-stress-protocol-case-control-neuroimaging-study
DO - http://ugeskriftet.dk/dmj/neurobiological-effects-work-related-stress-protocol-case-control-neuroimaging-study
M3 - Journal article
C2 - 30382017
VL - 65
JO - Danish Medical Journal
JF - Danish Medical Journal
SN - 2245-1919
IS - 11
M1 - A5513
ER -