Abstract
Scope: Milk powder is commonly consumed throughout the world. However, advanced glycation end products (AGEs) will form in milk powder during thermal processing and long-term storage. We aimed to identify such compounds with potential as new urinary biomarkers of intake of heat-treated skimmed milk powder (HSMP).
Methods and results: A parallel study was performed with different dosages of HSMP as well as hydrolyzed HSMP and untreated skimmed milk powder (SMP) in 36 rats. The 24-h urine samples on day 7 or 8 were collected and profiled by untargeted UPLC-Qtof-MS metabolomics. Statistical analysis revealed 25 metabolites differentiating SMP and HSMP; nineteen of these structures were proposed as lysine- and arginine- derived AGEs, and heterocyclic compounds.
Conclusion: These metabolites may potentially serve as biomarkers of food intake pending further validation to assess intakes of heat-processed dairy foods and thus help to elucidate the effects of HSMP consumption or dietary AGEs on human health.
Originalsprog | Engelsk |
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Artikelnummer | 2001049 |
Tidsskrift | Molecular Nutrition & Food Research |
Vol/bind | 65 |
Udgave nummer | 7 |
Antal sider | 9 |
ISSN | 1613-4125 |
DOI | |
Status | Udgivet - 2021 |
Bibliografisk note
CURIS 2021 NEXS 095Emneord
- Det Natur- og Biovidenskabelige Fakultet