Abstract
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 10495 |
| Tidsskrift | Nature Communications |
| Vol/bind | 7 |
| Sider (fra-til) | 1-15 |
| Antal sider | 15 |
| ISSN | 2041-1723 |
| DOI | |
| Status | Udgivet - 1 feb. 2016 |
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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. / Lu, Yingchang; Day, Felix R; Gustafsson, Stefan; Buchkovich, Martin L; Na, Jianbo; Bataille, Veronique; Cousminer, Diana L; Dastani, Zari; Drong, Alexander W; Esko, Tõnu; Evans, David M; Falchi, Mario; Feitosa, Mary F; Ferreira, Teresa; Hedman, Åsa K; Haring, Robin; Hysi, Pirro G; Iles, Mark M; Justice, Anne E; Kanoni, Stavroula; Lagou, Vasiliki; Li, Rui; Li, Xin; Locke, Adam; Lu, Chen; Mägi, Reedik; Perry, John R B; Pers, Tune H; Qi, Qibin; Sanna, Marianna; Schmidt, Ellen M; Scott, William R; Shungin, Dmitry; Teumer, Alexander; Vinkhuyzen, Anna A E; Walker, Ryan W; Westra, Harm-Jan; Zhang, Mingfeng; Zhang, Weihua; Zhao, Jing Hua; Zhu, Zhihong; Afzal, Uzma; Ahluwalia, Tarun Veer Singh; Bakker, Stephan J L; Bellis, Claire; Bonnefond, Amélie; Borodulin, Katja; Buchman, Aron S; Cederholm, Tommy; Choh, Audrey C; Choi, Hyung Jin; Curran, Joanne E; de Groot, Lisette C P G M; De Jager, Philip L; Dhonukshe-Rutten, Rosalie A M; Enneman, Anke W; Eury, Elodie; Evans, Daniel S; Forsen, Tom; Friedrich, Nele; Fumeron, Frédéric; Garcia, Melissa E; Gärtner, Simone; Han, Bok-Ghee; Havulinna, Aki S; Hayward, Caroline; Hernandez, Dena; Hillege, Hans; Ittermann, Till; Kent, Jack W; Kolcic, Ivana; Laatikainen, Tiina; Lahti, Jari; Mateo Leach, Irene; Lee, Christine G; Lee, Jong-Young; Liu, Tian; Liu, Youfang; Lobbens, Stéphane; Loh, Marie; Lyytikäinen, Leo-Pekka; Medina-Gomez, Carolina; Michaëlsson, Karl; Nalls, Mike A; Nielson, Carrie M; Oozageer, Laticia; Pascoe, Laura; Paternoster, Lavinia; Polašek, Ozren; Ripatti, Samuli; Sarzynski, Mark A; Shin, Chan Soo; Narančić, Nina Smolej; Spira, Dominik; Srikanth, Priya; Steinhagen-Thiessen, Elisabeth; Sung, Yun Ju; Swart, Karin M A; Taittonen, Leena; Tanaka, Toshiko; Tikkanen, Emmi; van der Velde, Nathalie; van Schoor, Natasja M; Verweij, Niek; Wright, Alan F; Yu, Lei; Zmuda, Joseph M; Eklund, Niina; Forrester, Terrence; Grarup, Niels; Jackson, Anne U; Kristiansson, Kati; Kuulasmaa, Teemu; Kuusisto, Johanna; Lichtner, Peter; Luan, Jian'an; Mahajan, Anubha; Männistö, Satu; Palmer, Cameron D; Ried, Janina S; Scott, Robert A; Stancáková, Alena; Wagner, Peter J; Demirkan, Ayse; Döring, Angela; Gudnason, Vilmundur; Kiel, Douglas P; Kühnel, Brigitte; Mangino, Massimo; Mcknight, Barbara; Menni, Cristina; O'Connell, Jeffrey R; Oostra, Ben A; Shuldiner, Alan R; Song, Kijoung; Vandenput, Liesbeth; van Duijn, Cornelia M; Vollenweider, Peter; White, Charles C; Boehnke, Michael; Boettcher, Yvonne; Cooper, Richard S; Forouhi, Nita G; Gieger, Christian; Grallert, Harald; Hingorani, Aroon; Jørgensen, Torben; Jousilahti, Pekka; Kivimaki, Mika; Kumari, Meena; Laakso, Markku; Langenberg, Claudia; Linneberg, Allan; Luke, Amy; Mckenzie, Colin A; Palotie, Aarno; Pedersen, Oluf; Peters, Annette; Strauch, Konstantin; Tayo, Bamidele O; Wareham, Nicholas J; Bennett, David A; Bertram, Lars; Blangero, John; Blüher, Matthias; Bouchard, Claude; Campbell, Harry; Cho, Nam H; Cummings, Steven R; Czerwinski, Stefan A; Demuth, Ilja; Eckardt, Rahel; Eriksson, Johan G; Ferrucci, Luigi; Franco, Oscar H; Froguel, Philippe; Gansevoort, Ron T; Hansen, Torben; Harris, Tamara B; Hastie, Nicholas; Heliövaara, Markku; Hofman, Albert; Jordan, Joanne M; Jula, Antti; Kähönen, Mika; Kajantie, Eero; Knekt, Paul B; Koskinen, Seppo; Kovacs, Peter; Lehtimäki, Terho; Lind, Lars; Liu, Yongmei; Orwoll, Eric S; Osmond, Clive; Perola, Markus; Pérusse, Louis; Raitakari, Olli T; Rankinen, Tuomo; Rao, D C; Rice, Treva K; Rivadeneira, Fernando; Rudan, Igor; Salomaa, Veikko; Sørensen, Thorkild I A; Stumvoll, Michael; Tönjes, Anke; Towne, Bradford; Tranah, Gregory J; Tremblay, Angelo; Uitterlinden, André G; van der Harst, Pim; Vartiainen, Erkki; Viikari, Jorma S; Vitart, Veronique; Vohl, Marie-Claude; Völzke, Henry; Walker, Mark; Wallaschofski, Henri; Wild, Sarah; Wilson, James F; Yengo, Loïc; Bishop, D Timothy; Borecki, Ingrid B; Chambers, John C; Cupples, L Adrienne; Dehghan, Abbas; Deloukas, Panos; Fatemifar, Ghazaleh; Fox, Caroline; Furey, Terrence S; Franke, Lude; Han, Jiali; Hunter, David J; Karjalainen, Juha; Karpe, Fredrik; Kaplan, Robert C; Kooner, Jaspal S; McCarthy, Mark I; Murabito, Joanne M; Morris, Andrew P; Bishop, Julia A N; North, Kari E; Ohlsson, Claes; Ong, Ken K; Prokopenko, Inga; Richards, J Brent; Schadt, Eric E; Spector, Tim D; Widén, Elisabeth; Willer, Cristen J; Yang, Jian; Ingelsson, Erik; Mohlke, Karen L; Hirschhorn, Joel N; Pospisilik, John Andrew; Zillikens, M Carola; Lindgren, Cecilia; Kilpeläinen, Tuomas Oskari; Loos, Ruth J F.
I: Nature Communications, Bind 7, 10495, 01.02.2016, s. 1-15.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
}
TY - JOUR
T1 - New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
AU - Lu, Yingchang
AU - Day, Felix R
AU - Gustafsson, Stefan
AU - Buchkovich, Martin L
AU - Na, Jianbo
AU - Bataille, Veronique
AU - Cousminer, Diana L
AU - Dastani, Zari
AU - Drong, Alexander W
AU - Esko, Tõnu
AU - Evans, David M
AU - Falchi, Mario
AU - Feitosa, Mary F
AU - Ferreira, Teresa
AU - Hedman, Åsa K
AU - Haring, Robin
AU - Hysi, Pirro G
AU - Iles, Mark M
AU - Justice, Anne E
AU - Kanoni, Stavroula
AU - Lagou, Vasiliki
AU - Li, Rui
AU - Li, Xin
AU - Locke, Adam
AU - Lu, Chen
AU - Mägi, Reedik
AU - Perry, John R B
AU - Pers, Tune H
AU - Qi, Qibin
AU - Sanna, Marianna
AU - Schmidt, Ellen M
AU - Scott, William R
AU - Shungin, Dmitry
AU - Teumer, Alexander
AU - Vinkhuyzen, Anna A E
AU - Walker, Ryan W
AU - Westra, Harm-Jan
AU - Zhang, Mingfeng
AU - Zhang, Weihua
AU - Zhao, Jing Hua
AU - Zhu, Zhihong
AU - Afzal, Uzma
AU - Ahluwalia, Tarun Veer Singh
AU - Bakker, Stephan J L
AU - Bellis, Claire
AU - Bonnefond, Amélie
AU - Borodulin, Katja
AU - Buchman, Aron S
AU - Cederholm, Tommy
AU - Choh, Audrey C
AU - Choi, Hyung Jin
AU - Curran, Joanne E
AU - de Groot, Lisette C P G M
AU - De Jager, Philip L
AU - Dhonukshe-Rutten, Rosalie A M
AU - Enneman, Anke W
AU - Eury, Elodie
AU - Evans, Daniel S
AU - Forsen, Tom
AU - Friedrich, Nele
AU - Fumeron, Frédéric
AU - Garcia, Melissa E
AU - Gärtner, Simone
AU - Han, Bok-Ghee
AU - Havulinna, Aki S
AU - Hayward, Caroline
AU - Hernandez, Dena
AU - Hillege, Hans
AU - Ittermann, Till
AU - Kent, Jack W
AU - Kolcic, Ivana
AU - Laatikainen, Tiina
AU - Lahti, Jari
AU - Mateo Leach, Irene
AU - Lee, Christine G
AU - Lee, Jong-Young
AU - Liu, Tian
AU - Liu, Youfang
AU - Lobbens, Stéphane
AU - Loh, Marie
AU - Lyytikäinen, Leo-Pekka
AU - Medina-Gomez, Carolina
AU - Michaëlsson, Karl
AU - Nalls, Mike A
AU - Nielson, Carrie M
AU - Oozageer, Laticia
AU - Pascoe, Laura
AU - Paternoster, Lavinia
AU - Polašek, Ozren
AU - Ripatti, Samuli
AU - Sarzynski, Mark A
AU - Shin, Chan Soo
AU - Narančić, Nina Smolej
AU - Spira, Dominik
AU - Srikanth, Priya
AU - Steinhagen-Thiessen, Elisabeth
AU - Sung, Yun Ju
AU - Swart, Karin M A
AU - Taittonen, Leena
AU - Tanaka, Toshiko
AU - Tikkanen, Emmi
AU - van der Velde, Nathalie
AU - van Schoor, Natasja M
AU - Verweij, Niek
AU - Wright, Alan F
AU - Yu, Lei
AU - Zmuda, Joseph M
AU - Eklund, Niina
AU - Forrester, Terrence
AU - Grarup, Niels
AU - Jackson, Anne U
AU - Kristiansson, Kati
AU - Kuulasmaa, Teemu
AU - Kuusisto, Johanna
AU - Lichtner, Peter
AU - Luan, Jian'an
AU - Mahajan, Anubha
AU - Männistö, Satu
AU - Palmer, Cameron D
AU - Ried, Janina S
AU - Scott, Robert A
AU - Stancáková, Alena
AU - Wagner, Peter J
AU - Demirkan, Ayse
AU - Döring, Angela
AU - Gudnason, Vilmundur
AU - Kiel, Douglas P
AU - Kühnel, Brigitte
AU - Mangino, Massimo
AU - Mcknight, Barbara
AU - Menni, Cristina
AU - O'Connell, Jeffrey R
AU - Oostra, Ben A
AU - Shuldiner, Alan R
AU - Song, Kijoung
AU - Vandenput, Liesbeth
AU - van Duijn, Cornelia M
AU - Vollenweider, Peter
AU - White, Charles C
AU - Boehnke, Michael
AU - Boettcher, Yvonne
AU - Cooper, Richard S
AU - Forouhi, Nita G
AU - Gieger, Christian
AU - Grallert, Harald
AU - Hingorani, Aroon
AU - Jørgensen, Torben
AU - Jousilahti, Pekka
AU - Kivimaki, Mika
AU - Kumari, Meena
AU - Laakso, Markku
AU - Langenberg, Claudia
AU - Linneberg, Allan
AU - Luke, Amy
AU - Mckenzie, Colin A
AU - Palotie, Aarno
AU - Pedersen, Oluf
AU - Peters, Annette
AU - Strauch, Konstantin
AU - Tayo, Bamidele O
AU - Wareham, Nicholas J
AU - Bennett, David A
AU - Bertram, Lars
AU - Blangero, John
AU - Blüher, Matthias
AU - Bouchard, Claude
AU - Campbell, Harry
AU - Cho, Nam H
AU - Cummings, Steven R
AU - Czerwinski, Stefan A
AU - Demuth, Ilja
AU - Eckardt, Rahel
AU - Eriksson, Johan G
AU - Ferrucci, Luigi
AU - Franco, Oscar H
AU - Froguel, Philippe
AU - Gansevoort, Ron T
AU - Hansen, Torben
AU - Harris, Tamara B
AU - Hastie, Nicholas
AU - Heliövaara, Markku
AU - Hofman, Albert
AU - Jordan, Joanne M
AU - Jula, Antti
AU - Kähönen, Mika
AU - Kajantie, Eero
AU - Knekt, Paul B
AU - Koskinen, Seppo
AU - Kovacs, Peter
AU - Lehtimäki, Terho
AU - Lind, Lars
AU - Liu, Yongmei
AU - Orwoll, Eric S
AU - Osmond, Clive
AU - Perola, Markus
AU - Pérusse, Louis
AU - Raitakari, Olli T
AU - Rankinen, Tuomo
AU - Rao, D C
AU - Rice, Treva K
AU - Rivadeneira, Fernando
AU - Rudan, Igor
AU - Salomaa, Veikko
AU - Sørensen, Thorkild I A
AU - Stumvoll, Michael
AU - Tönjes, Anke
AU - Towne, Bradford
AU - Tranah, Gregory J
AU - Tremblay, Angelo
AU - Uitterlinden, André G
AU - van der Harst, Pim
AU - Vartiainen, Erkki
AU - Viikari, Jorma S
AU - Vitart, Veronique
AU - Vohl, Marie-Claude
AU - Völzke, Henry
AU - Walker, Mark
AU - Wallaschofski, Henri
AU - Wild, Sarah
AU - Wilson, James F
AU - Yengo, Loïc
AU - Bishop, D Timothy
AU - Borecki, Ingrid B
AU - Chambers, John C
AU - Cupples, L Adrienne
AU - Dehghan, Abbas
AU - Deloukas, Panos
AU - Fatemifar, Ghazaleh
AU - Fox, Caroline
AU - Furey, Terrence S
AU - Franke, Lude
AU - Han, Jiali
AU - Hunter, David J
AU - Karjalainen, Juha
AU - Karpe, Fredrik
AU - Kaplan, Robert C
AU - Kooner, Jaspal S
AU - McCarthy, Mark I
AU - Murabito, Joanne M
AU - Morris, Andrew P
AU - Bishop, Julia A N
AU - North, Kari E
AU - Ohlsson, Claes
AU - Ong, Ken K
AU - Prokopenko, Inga
AU - Richards, J Brent
AU - Schadt, Eric E
AU - Spector, Tim D
AU - Widén, Elisabeth
AU - Willer, Cristen J
AU - Yang, Jian
AU - Ingelsson, Erik
AU - Mohlke, Karen L
AU - Hirschhorn, Joel N
AU - Pospisilik, John Andrew
AU - Zillikens, M Carola
AU - Lindgren, Cecilia
AU - Kilpeläinen, Tuomas Oskari
AU - Loos, Ruth J F
PY - 2016/2/1
Y1 - 2016/2/1
N2 - To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
AB - To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
U2 - 10.1038/ncomms10495
DO - 10.1038/ncomms10495
M3 - Journal article
C2 - 26833246
VL - 7
SP - 1
EP - 15
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 10495
ER -