Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Journal of Neurosurgery |
| Vol/bind | 110 |
| Udgave nummer | 1 |
| Sider (fra-til) | 58-63 |
| Antal sider | 5 |
| ISSN | 0022-3085 |
| DOI | |
| Status | Udgivet - 2009 |
Bibliografisk note
Keywords: Administration, Oral; Aged; Calcium Channel Blockers; Endpoint Determination; Female; Follow-Up Studies; Glasgow Coma Scale; Humans; Injections, Intravenous; Magnetic Resonance Imaging; Male; Middle Aged; Nimodipine; Prospective Studies; Subarachnoid Hemorrhage; Tomography, X-Ray Computed; Treatment Outcome; Vasospasm, IntracranialAdgang til dokumentet
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Nimodipine in aneurysmal subarachnoid hemorrhage: a randomized study of intravenous or peroral administration. / Kronvall, Erik; Undrén, Per; Rommer, Bertil Roland; Säveland, Hans; Cronqvist, Mats; Nilsson, Ola G.
I: Journal of Neurosurgery, Bind 110, Nr. 1, 2009, s. 58-63.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Nimodipine in aneurysmal subarachnoid hemorrhage: a randomized study of intravenous or peroral administration
AU - Kronvall, Erik
AU - Undrén, Per
AU - Rommer, Bertil Roland
AU - Säveland, Hans
AU - Cronqvist, Mats
AU - Nilsson, Ola G
N1 - Keywords: Administration, Oral; Aged; Calcium Channel Blockers; Endpoint Determination; Female; Follow-Up Studies; Glasgow Coma Scale; Humans; Injections, Intravenous; Magnetic Resonance Imaging; Male; Middle Aged; Nimodipine; Prospective Studies; Subarachnoid Hemorrhage; Tomography, X-Ray Computed; Treatment Outcome; Vasospasm, Intracranial
PY - 2009
Y1 - 2009
N2 - OBJECT: The calcium antagonist nimodipine has been shown to reduce the incidence of ischemic complications following aneurysmal subarachnoid hemorrhage (SAH). Although most randomized studies have been focused on the effect of the peroral administration of nimodipine, intravenous infusion is an alternative and the preferred mode of treatment in many centers. It is unknown whether the route of administration is of any importance for the clinical efficacy of the drug. METHODS: One hundred six patients with acute aneurysmal SAH were randomized to receive either peroral or intravenous nimodipine treatment. The patients were monitored for at least 10 days after bleeding in terms of delayed ischemic neurological deficits (DINDs) and with daily measurements of blood flow velocities in the middle cerebral arteries by using transcranial Doppler ultrasonography. Three months after SAH, clinical outcome and new cerebral infarctions according to MR imaging studies were recorded. RESULTS: Baseline characteristics (age, sex distribution, clinical status on admission, radiological findings, and aneurysm treatment) did not differ between the treatment groups. There was no significant difference in the incidence of DINDs (28 vs 30% in the peroral and intravenous groups, respectively) or middle cerebral artery blood flow velocities (> 120 cm/second, 50 vs 45%, respectively). Clinical outcome according to the Glasgow Outcome Scale was the same in both groups, and there was no difference in the number of patients with new infarctions on MR imaging. CONCLUSIONS: The results suggest that there is no clinically relevant difference in efficacy between peroral and intravenous administration of nimodipine in preventing DINDs or cerebral vasospasm following SAH.
AB - OBJECT: The calcium antagonist nimodipine has been shown to reduce the incidence of ischemic complications following aneurysmal subarachnoid hemorrhage (SAH). Although most randomized studies have been focused on the effect of the peroral administration of nimodipine, intravenous infusion is an alternative and the preferred mode of treatment in many centers. It is unknown whether the route of administration is of any importance for the clinical efficacy of the drug. METHODS: One hundred six patients with acute aneurysmal SAH were randomized to receive either peroral or intravenous nimodipine treatment. The patients were monitored for at least 10 days after bleeding in terms of delayed ischemic neurological deficits (DINDs) and with daily measurements of blood flow velocities in the middle cerebral arteries by using transcranial Doppler ultrasonography. Three months after SAH, clinical outcome and new cerebral infarctions according to MR imaging studies were recorded. RESULTS: Baseline characteristics (age, sex distribution, clinical status on admission, radiological findings, and aneurysm treatment) did not differ between the treatment groups. There was no significant difference in the incidence of DINDs (28 vs 30% in the peroral and intravenous groups, respectively) or middle cerebral artery blood flow velocities (> 120 cm/second, 50 vs 45%, respectively). Clinical outcome according to the Glasgow Outcome Scale was the same in both groups, and there was no difference in the number of patients with new infarctions on MR imaging. CONCLUSIONS: The results suggest that there is no clinically relevant difference in efficacy between peroral and intravenous administration of nimodipine in preventing DINDs or cerebral vasospasm following SAH.
U2 - 10.3171/2008.7.JNS08178
DO - 10.3171/2008.7.JNS08178
M3 - Journal article
C2 - 18847340
VL - 110
SP - 58
EP - 63
JO - Journal of Neurosurgery
JF - Journal of Neurosurgery
SN - 0022-3085
IS - 1
ER -