Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt

J Størling, J Binzer, Annica Andersson, R A Züllig, M Tonnesen, René Lehmann Pulz Knudsen, G A Spinas, S Sandler, N Billestrup, Thomas Mandrup-Poulsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

125 Citationer (Scopus)

Abstract

Pro-inflammatory cytokines cause beta cell secretory dysfunction and apoptosis--a process implicated in the pathogenesis of type 1 diabetes. Cytokines induce the expression of inducible nitric oxide (NO) synthase (iNOS) leading to NO production. NO contributes to cytokine-induced apoptosis, but the underlying mechanisms are unclear. The aim of this study was to investigate whether NO modulates signalling via mitogen-activated protein kinases (MAPKs) and Akt.
OriginalsprogEngelsk
TidsskriftDiabetologia
Vol/bind48
Udgave nummer10
Sider (fra-til)2039-50
Antal sider12
ISSN0012-186X
DOI
StatusUdgivet - 1 okt. 2005

Citationsformater