No effect of melatonin to modify surgical-stress response after major vascular surgery: a randomised placebo-controlled trial

B Kücükakin; M Wilhelmsen; Jens Lykkesfeldt; R J Reiter; J Rosenberg; I Gögenur

doi:10.1016/j.ejvs.2010.06.014

No effect of melatonin to modify surgical-stress response after major vascular surgery: a randomised placebo-controlled trial

B Kücükakin, M Wilhelmsen, Jens Lykkesfeldt, R J Reiter, J Rosenberg, I Gögenur

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

30 Citationer (Scopus)

Abstract

A possible mechanism underlying cardiovascular morbidity after major vascular surgery may be the perioperative ischaemia-reperfusion with excessive oxygen-derived free-radical production and increased levels of circulating inflammatory mediators. We examined the effect of melatonin infusion during surgery and oral melatonin treatment for 3 days after surgery on biochemical markers of oxidative and inflammatory stress.

Originalsprog	Engelsk
Tidsskrift	European Journal of Vascular and Endovascular Surgery
Vol/bind	40
Udgave nummer	4
Sider (fra-til)	461-7
Antal sider	7
ISSN	1078-5884
DOI	https://doi.org/10.1016/j.ejvs.2010.06.014
Status	Udgivet - 1 okt. 2010

Adgang til dokumentet

10.1016/j.ejvs.2010.06.014

Biblioteksadgang?

Tjek tilgængelighed hos det Kgl. Bibliotek

Citationsformater

@article{70fee6baa6fa4118befec406c8a52443,

title = "No effect of melatonin to modify surgical-stress response after major vascular surgery: a randomised placebo-controlled trial",

abstract = "A possible mechanism underlying cardiovascular morbidity after major vascular surgery may be the perioperative ischaemia-reperfusion with excessive oxygen-derived free-radical production and increased levels of circulating inflammatory mediators. We examined the effect of melatonin infusion during surgery and oral melatonin treatment for 3 days after surgery on biochemical markers of oxidative and inflammatory stress.",

author = "B K{\"u}c{\"u}kakin and M Wilhelmsen and Jens Lykkesfeldt and Reiter, {R J} and J Rosenberg and I G{\"o}genur",

year = "2010",

month = oct,

day = "1",

doi = "10.1016/j.ejvs.2010.06.014",

language = "English",

volume = "40",

pages = "461--7",

journal = "European Journal of Vascular and Endovascular Surgery",

issn = "1078-5884",

publisher = "Elsevier",

number = "4",

}

TY - JOUR

T1 - No effect of melatonin to modify surgical-stress response after major vascular surgery: a randomised placebo-controlled trial

AU - Kücükakin, B

AU - Wilhelmsen, M

AU - Lykkesfeldt, Jens

AU - Reiter, R J

AU - Rosenberg, J

AU - Gögenur, I

PY - 2010/10/1

Y1 - 2010/10/1

N2 - A possible mechanism underlying cardiovascular morbidity after major vascular surgery may be the perioperative ischaemia-reperfusion with excessive oxygen-derived free-radical production and increased levels of circulating inflammatory mediators. We examined the effect of melatonin infusion during surgery and oral melatonin treatment for 3 days after surgery on biochemical markers of oxidative and inflammatory stress.

AB - A possible mechanism underlying cardiovascular morbidity after major vascular surgery may be the perioperative ischaemia-reperfusion with excessive oxygen-derived free-radical production and increased levels of circulating inflammatory mediators. We examined the effect of melatonin infusion during surgery and oral melatonin treatment for 3 days after surgery on biochemical markers of oxidative and inflammatory stress.

U2 - 10.1016/j.ejvs.2010.06.014

DO - 10.1016/j.ejvs.2010.06.014

M3 - Journal article

SN - 1078-5884

VL - 40

SP - 461

EP - 467

JO - European Journal of Vascular and Endovascular Surgery

JF - European Journal of Vascular and Endovascular Surgery

IS - 4

ER -