TY - JOUR
T1 - No effects of a 6-week intervention with a glucagon-like peptide-1 receptor agonist on pancreatic volume and oedema in obese men without diabetes
AU - Svane, Maria S.
AU - Johannesen, Helle H.
AU - Martinussen, Christoffer
AU - Bojsen-Moller, Kirstine N.
AU - Hansen, Martin Lundsgaard
AU - Hansen, Adam E.
AU - Deacon, Carolyn F.
AU - Hartmann, Bolette
AU - Keller, Sune H.
AU - Klausen, Thomas L.
AU - Loft, Annika
AU - Kjaer, Andreas
AU - Madsbad, Sten
AU - Lofgren, Johan
AU - Holst, Jens J.
AU - Wewer Albrechtsen, Nicolai J.
PY - 2020
Y1 - 2020
N2 - Aim To investigate the effect of a glucagon-like peptide-1 receptor agonist (GLP-1RA), liraglutide, on pancreatic volume, oedema, cellularity and DNA synthesis in humans. Materials and Methods We performed an open-label study in 14 obese men (age 38 +/- 11 years, body mass index 32 +/- 4 kg/m(2)) without diabetes. Subjects were examined at baseline, during titration (week 4) of liraglutide towards 3.0 mg/day, and 2 weeks after steady-state treatment (week 6) of a final dose of liraglutide. The primary endpoint was pancreatic volume determined by magnetic resonance imaging. Secondary endpoints included pancreatic oedema and cellularity, positron emission tomography-based [F-18]fluorothymidine (FLT) uptake (DNA synthesis) and plasma pancreatic enzymes. Results Plasma amylase (+7 U/L [95% confidence intervals 3-11],P < .01) and lipase (+19 U/L [7-30],P < .01) increased during liraglutide treatment. Pancreatic volume did not change from baseline to steady state of treatment (+0.2 cm(3)[-8-8],P= .96) and no change in pancreatic cellular infiltration was found (P= .22). During titration of liraglutide, FLT uptake in pancreatic tissue increased numerically (+0.08 [0.00-0.17],P= .0507). Conclusions Six weeks of treatment with liraglutide did not affect pancreatic volume, oedema or cellularity in obese men without diabetes.
Keywords
AB - Aim To investigate the effect of a glucagon-like peptide-1 receptor agonist (GLP-1RA), liraglutide, on pancreatic volume, oedema, cellularity and DNA synthesis in humans. Materials and Methods We performed an open-label study in 14 obese men (age 38 +/- 11 years, body mass index 32 +/- 4 kg/m(2)) without diabetes. Subjects were examined at baseline, during titration (week 4) of liraglutide towards 3.0 mg/day, and 2 weeks after steady-state treatment (week 6) of a final dose of liraglutide. The primary endpoint was pancreatic volume determined by magnetic resonance imaging. Secondary endpoints included pancreatic oedema and cellularity, positron emission tomography-based [F-18]fluorothymidine (FLT) uptake (DNA synthesis) and plasma pancreatic enzymes. Results Plasma amylase (+7 U/L [95% confidence intervals 3-11],P < .01) and lipase (+19 U/L [7-30],P < .01) increased during liraglutide treatment. Pancreatic volume did not change from baseline to steady state of treatment (+0.2 cm(3)[-8-8],P= .96) and no change in pancreatic cellular infiltration was found (P= .22). During titration of liraglutide, FLT uptake in pancreatic tissue increased numerically (+0.08 [0.00-0.17],P= .0507). Conclusions Six weeks of treatment with liraglutide did not affect pancreatic volume, oedema or cellularity in obese men without diabetes.
Keywords
KW - antiobesity drug clinical trial GLP-1 analogue
U2 - 10.1111/dom.14106
DO - 10.1111/dom.14106
M3 - Journal article
C2 - 32495988
VL - 22
SP - 1837
EP - 1846
JO - Diabetes, Obesity and Metabolism
JF - Diabetes, Obesity and Metabolism
SN - 1462-8902
IS - 10
ER -