Non-essential genes form the hubs of genome scale protein function and environmental gene expression networks in Salmonella enterica serovar Typhimurium

Jesper Tjørnhøj Rosenkrantz; Henk Aarts; Tjakko Abee; Matthew D. Rolfe; Gitte Maegaard Knudsen; Maj-Britt Nielsen; Line Elnif Thomsen; Marcel H. Zwietering; John Elmerdahl Olsen; Carmen Pin

doi:10.1186/1471-2180-13-294

Non-essential genes form the hubs of genome scale protein function and environmental gene expression networks in Salmonella enterica serovar Typhimurium

Jesper Tjørnhøj Rosenkrantz, Henk Aarts, Tjakko Abee, Matthew D. Rolfe, Gitte Maegaard Knudsen, Maj-Britt Nielsen, Line Elnif Thomsen, Marcel H. Zwietering, John Elmerdahl Olsen, Carmen Pin

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

10 Citationer (Scopus)

Abstract

Salmonella Typhimurium is an important pathogen of human and animals. It shows a broad growth range and survives in harsh conditions. The aim of this study was to analyze transcriptional responses to a number of growth and stress conditions as well as the relationship of metabolic pathways and/or cell functions at the genome-scale-level by network analysis, and further to explore whether highly connected genes (hubs) in these networks were essential for growth, stress adaptation and virulence.

Originalsprog	Engelsk
Artikelnummer	294
Tidsskrift	B M C Microbiology
Vol/bind	13
Antal sider	16
ISSN	1471-2180
DOI	https://doi.org/10.1186/1471-2180-13-294
Status	Udgivet - 2013

Emneord

Det Sundhedsvidenskabelige Fakultet
Salmonella
regulation
metabolism
genom scale network

Adgang til dokumentet

10.1186/1471-2180-13-294

Citationsformater

Rosenkrantz, J. T., Aarts, H., Abee, T., Rolfe, M. D., Knudsen, G. M., Nielsen, M.-B., Thomsen, L. E., Zwietering, M. H., Olsen, J. E., & Pin, C. (2013). Non-essential genes form the hubs of genome scale protein function and environmental gene expression networks in Salmonella enterica serovar Typhimurium. B M C Microbiology, 13, Artikel 294. https://doi.org/10.1186/1471-2180-13-294

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title = "Non-essential genes form the hubs of genome scale protein function and environmental gene expression networks in Salmonella enterica serovar Typhimurium",

abstract = "Salmonella Typhimurium is an important pathogen of human and animals. It shows a broad growth range and survives in harsh conditions. The aim of this study was to analyze transcriptional responses to a number of growth and stress conditions as well as the relationship of metabolic pathways and/or cell functions at the genome-scale-level by network analysis, and further to explore whether highly connected genes (hubs) in these networks were essential for growth, stress adaptation and virulence.",

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author = "Rosenkrantz, {Jesper Tj{\o}rnh{\o}j} and Henk Aarts and Tjakko Abee and Rolfe, {Matthew D.} and Knudsen, {Gitte Maegaard} and Maj-Britt Nielsen and Thomsen, {Line Elnif} and Zwietering, {Marcel H.} and Olsen, {John Elmerdahl} and Carmen Pin",

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doi = "10.1186/1471-2180-13-294",

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T1 - Non-essential genes form the hubs of genome scale protein function and environmental gene expression networks in Salmonella enterica serovar Typhimurium

AU - Rosenkrantz, Jesper Tjørnhøj

AU - Aarts, Henk

AU - Abee, Tjakko

AU - Rolfe, Matthew D.

AU - Knudsen, Gitte Maegaard

AU - Nielsen, Maj-Britt

AU - Thomsen, Line Elnif

AU - Zwietering, Marcel H.

AU - Olsen, John Elmerdahl

AU - Pin, Carmen

PY - 2013

Y1 - 2013

N2 - Salmonella Typhimurium is an important pathogen of human and animals. It shows a broad growth range and survives in harsh conditions. The aim of this study was to analyze transcriptional responses to a number of growth and stress conditions as well as the relationship of metabolic pathways and/or cell functions at the genome-scale-level by network analysis, and further to explore whether highly connected genes (hubs) in these networks were essential for growth, stress adaptation and virulence.

AB - Salmonella Typhimurium is an important pathogen of human and animals. It shows a broad growth range and survives in harsh conditions. The aim of this study was to analyze transcriptional responses to a number of growth and stress conditions as well as the relationship of metabolic pathways and/or cell functions at the genome-scale-level by network analysis, and further to explore whether highly connected genes (hubs) in these networks were essential for growth, stress adaptation and virulence.

KW - Faculty of Health and Medical Sciences

KW - Salmonella

KW - regulation

KW - metabolism

KW - genom scale network

U2 - 10.1186/1471-2180-13-294

DO - 10.1186/1471-2180-13-294

M3 - Journal article

C2 - 24345035

SN - 1471-2180

VL - 13

JO - B M C Microbiology

JF - B M C Microbiology

M1 - 294

ER -