Non-Invasive Assessment of Intravascular Pressure Gradients: A Review of Current and Proposed Novel Methods

Tin-Quoc Nguyen, Kristoffer Lindskov Hansen, Thor Bechsgaard, Lars Lonn, Jørgen Arendt Jensen, Michael Bachmann Nielsen

Publikation: Bidrag til tidsskriftReviewForskningpeer review

9 Citationer (Scopus)
94 Downloads (Pure)

Abstract

Invasive catheterization is associated with a low risk of serious complications. However, although it is the gold standard for measuring pressure gradients, it induces changes to blood flow and requires significant resources. Therefore, non-invasive alternatives are urgently needed. Pressure gradients are routinely estimated non-invasively in clinical settings using ultrasound and calculated with the simplified Bernoulli equation, a method with several limitations. A PubMed literature search on validation of non-invasive techniques was conducted, and studies were included if non-invasively estimated pressure gradients were compared with invasively measured pressure gradients in vivo. Pressure gradients were mainly estimated from velocities obtained with Doppler ultrasound or magnetic resonance imaging. Most studies used the simplified Bernoulli equation, but more recent studies have employed the expanded Bernoulli and Navier–Stokes equations. Overall, the studies reported good correlation between non-invasive estimation of pressure gradients and catheterization. Despite having strong correlations, several studies reported the non-invasive techniques to either overestimate or underestimate the invasive measurements, thus questioning the accuracy of the non-invasive methods. In conclusion, more advanced imaging techniques may be needed to overcome the shortcomings of current methods
OriginalsprogEngelsk
Artikelnummer5
TidsskriftDiagnostics
Vol/bind9
Udgave nummer1
Antal sider19
ISSN2075-4418
DOI
StatusUdgivet - 2019

Bibliografisk note

This article belongs to the Special Issue Imaging-Based Diagnostics in Interventional Medicine

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