Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | American Journal of Physiology: Regulatory, Integrative and Comparative Physiology |
| Vol/bind | 288 |
| Udgave nummer | 5 |
| Sider (fra-til) | R1143-59 |
| ISSN | 0363-6119 |
| DOI | |
| Status | Udgivet - 2005 |
Bibliografisk note
Keywords: Blood Pressure; Calcium; Feedback, Biochemical; Glomerular Filtration Rate; Kidney; Membrane Potentials; Models, Biological; Nonlinear Dynamics; Potassium; Renal Circulation; Sodium ChlorideAdgang til dokumentet
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Nonlinear interactions in renal blood flow regulation. / Marsh, Donald J; Sosnovtseva, Olga; Chon, Ki H; Holstein-Rathlou, N.-H.
I: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Bind 288, Nr. 5, 2005, s. R1143-59.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Nonlinear interactions in renal blood flow regulation.
AU - Marsh, Donald J
AU - Sosnovtseva, Olga
AU - Chon, Ki H
AU - Holstein-Rathlou, N.-H.
N1 - Keywords: Blood Pressure; Calcium; Feedback, Biochemical; Glomerular Filtration Rate; Kidney; Membrane Potentials; Models, Biological; Nonlinear Dynamics; Potassium; Renal Circulation; Sodium Chloride
PY - 2005
Y1 - 2005
N2 - We have developed a model of tubuloglomerular feedback (TGF) and the myogenic mechanism in afferent arterioles to understand how the two mechanisms are coupled. This paper presents the model. The tubular model predicts pressure, flow, and NaCl concentration as functions of time and tubular length in a compliant tubule that reabsorbs NaCl and water; boundary conditions are glomerular filtration rate (GFR), a nonlinear outflow resistance, and initial NaCl concentration. The glomerular model calculates GFR from a change in protein concentration using estimates of capillary hydrostatic pressure, tubular hydrostatic pressure, and plasma flow rate. The arteriolar model predicts fraction of open K channels, intracellular Ca concentration (Ca(i)), potential difference, rate of actin-myosin cross bridge formation, force of contraction, and length of elastic elements, and was solved for two arteriolar segments, identical except for the strength of TGF input, with a third, fixed resistance segment representing prearteriolar vessels. The two arteriolar segments are electrically coupled. The arteriolar, glomerular, and tubular models are linked; TGF modulates arteriolar circumference, which determines vascular resistance and glomerular capillary pressure. The model couples TGF input to voltage-gated Ca channels. It predicts autoregulation of GFR and renal blood flow, matches experimental measures of tubular pressure and macula densa NaCl concentration, and predicts TGF-induced oscillations and a faster smaller vasomotor oscillation. There are nonlinear interactions between TGF and the myogenic mechanism, which include the modulation of the frequency and amplitude of the myogenic oscillation by TGF. The prediction of modulation is confirmed in a companion study (28).
AB - We have developed a model of tubuloglomerular feedback (TGF) and the myogenic mechanism in afferent arterioles to understand how the two mechanisms are coupled. This paper presents the model. The tubular model predicts pressure, flow, and NaCl concentration as functions of time and tubular length in a compliant tubule that reabsorbs NaCl and water; boundary conditions are glomerular filtration rate (GFR), a nonlinear outflow resistance, and initial NaCl concentration. The glomerular model calculates GFR from a change in protein concentration using estimates of capillary hydrostatic pressure, tubular hydrostatic pressure, and plasma flow rate. The arteriolar model predicts fraction of open K channels, intracellular Ca concentration (Ca(i)), potential difference, rate of actin-myosin cross bridge formation, force of contraction, and length of elastic elements, and was solved for two arteriolar segments, identical except for the strength of TGF input, with a third, fixed resistance segment representing prearteriolar vessels. The two arteriolar segments are electrically coupled. The arteriolar, glomerular, and tubular models are linked; TGF modulates arteriolar circumference, which determines vascular resistance and glomerular capillary pressure. The model couples TGF input to voltage-gated Ca channels. It predicts autoregulation of GFR and renal blood flow, matches experimental measures of tubular pressure and macula densa NaCl concentration, and predicts TGF-induced oscillations and a faster smaller vasomotor oscillation. There are nonlinear interactions between TGF and the myogenic mechanism, which include the modulation of the frequency and amplitude of the myogenic oscillation by TGF. The prediction of modulation is confirmed in a companion study (28).
U2 - 10.1152/ajpregu.00539.2004
DO - 10.1152/ajpregu.00539.2004
M3 - Journal article
C2 - 15677526
VL - 288
SP - R1143-59
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0363-6119
IS - 5
ER -