Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Cell Cycle |
| Vol/bind | 3 |
| Udgave nummer | 6 |
| Sider (fra-til) | 774-8 |
| Antal sider | 4 |
| ISSN | 1538-4101 |
| Status | Udgivet - 2004 |
Bibliografisk note
Keywords: Adipose Tissue; Animals; Retinoblastoma ProteinCitationsformater
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Novel function of the retinoblastoma protein in fat: regulation of white versus brown adipocyte differentiation. / Hansen, Jacob B; te Riele, Hein; Kristiansen, Karsten.
I: Cell Cycle, Bind 3, Nr. 6, 2004, s. 774-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › peer review
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TY - JOUR
T1 - Novel function of the retinoblastoma protein in fat: regulation of white versus brown adipocyte differentiation.
AU - Hansen, Jacob B
AU - te Riele, Hein
AU - Kristiansen, Karsten
N1 - Keywords: Adipose Tissue; Animals; Retinoblastoma Protein
PY - 2004
Y1 - 2004
N2 - The differentiation of white and brown fat cells is controlled by a similar set of transcription factors, including PPARgamma and C/EBPalpha. However, despite many similarities between the two types of fat cells, they carry out essentially opposite functions in vivo, with white adipocytes being the major energy store and brown adipocytes being potent energy-dissipaters through thermogenesis. Yet, little is known about factors differentially regulating the formation of white and brown fat cells. Members of the retinoblastoma protein family (pRB, p107, p130) have been implicated in the regulation of adipocyte differentiation, and expression and phosphorylation of the three retinoblastoma family proteins oscillate in a characteristic manner during differentiation of the white preadipocyte cell line 3T3-L1. We have recently demonstrated a surprising function of the retinoblastoma protein in the regulation of white versus brown adipocyte differentiation in vitro and possibly in vivo. Here we summarize the current knowledge on the retinoblastoma protein in fat cells, with particular emphasis on its potential role in adipocyte lineage commitment and differentiation.
AB - The differentiation of white and brown fat cells is controlled by a similar set of transcription factors, including PPARgamma and C/EBPalpha. However, despite many similarities between the two types of fat cells, they carry out essentially opposite functions in vivo, with white adipocytes being the major energy store and brown adipocytes being potent energy-dissipaters through thermogenesis. Yet, little is known about factors differentially regulating the formation of white and brown fat cells. Members of the retinoblastoma protein family (pRB, p107, p130) have been implicated in the regulation of adipocyte differentiation, and expression and phosphorylation of the three retinoblastoma family proteins oscillate in a characteristic manner during differentiation of the white preadipocyte cell line 3T3-L1. We have recently demonstrated a surprising function of the retinoblastoma protein in the regulation of white versus brown adipocyte differentiation in vitro and possibly in vivo. Here we summarize the current knowledge on the retinoblastoma protein in fat cells, with particular emphasis on its potential role in adipocyte lineage commitment and differentiation.
M3 - Journal article
C2 - 15197340
VL - 3
SP - 774
EP - 778
JO - Cell Cycle
JF - Cell Cycle
SN - 1538-4101
IS - 6
ER -