Novel Function of the Retinoblastoma Protein in Fat: Regulation of White Versus Brown Adipocyte Differentiation

Jacob B. Hansen,; Hein te Riele; Karsten Kristiansen

Novel Function of the Retinoblastoma Protein in Fat: Regulation of White Versus Brown Adipocyte Differentiation

Jacob B. Hansen,, Hein te Riele, Karsten Kristiansen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

25 Citationer (Scopus)

Abstract

Udgivelsesdato: June 2004

Originalsprog	Engelsk
Tidsskrift	Cell Cycle
Vol/bind	3
Udgave nummer	6
Sider (fra-til)	772-776
ISSN	1538-4101
Status	Udgivet - 2004
Udgivet eksternt	Ja

Adgang til dokumentet

http://www.landesbioscience.com/journals/cc/article/hansenCC3-6.pdf

Citationsformater

@article{a48f64f0a8ed11debc73000ea68e967b,

title = "Novel Function of the Retinoblastoma Protein in Fat: Regulation of White Versus Brown Adipocyte Differentiation",

abstract = "The differentiation of white and brown fat cells is controlled by a similar set of transcription factors, including PPAR? and C/EBP?. However, despite many similarities between the two types of fat cells, they carry out essentially opposite functions in vivo, with white adipocytes being the major energy store and brown adipocytes being potent energy-dissipaters through thermogenesis. Yet, little is known about factors differentially regulating the formation of white and brown fat cells. Members of the retinoblastoma protein family (pRB, p107, p130) have been implicated in the regulation of adipocyte differentiation, and expression and phosphorylation of the three retinoblastoma family proteins oscillate in a characteristic manner during differentiation of the white preadipocyte cell line 3T3-L1. We have recently demonstrated a surprising function of the retinoblastoma protein in the regulation of white versus brown adipocyte differentiation in vitro and possibly in vivo. Here we summarize the current knowledge on the retinoblastoma protein in fat cells, with particular emphasis on its potential role in adipocyte lineage commitment and differentiation.",

author = "Hansen,, {Jacob B.} and Riele, {Hein te} and Karsten Kristiansen",

year = "2004",

language = "English",

volume = "3",

pages = "772--776",

journal = "Cell Cycle",

issn = "1538-4101",

publisher = "Taylor & Francis",

number = "6",

}

TY - JOUR

T1 - Novel Function of the Retinoblastoma Protein in Fat: Regulation of White Versus Brown Adipocyte Differentiation

AU - Hansen,, Jacob B.

AU - Riele, Hein te

AU - Kristiansen, Karsten

PY - 2004

Y1 - 2004

N2 - The differentiation of white and brown fat cells is controlled by a similar set of transcription factors, including PPAR? and C/EBP?. However, despite many similarities between the two types of fat cells, they carry out essentially opposite functions in vivo, with white adipocytes being the major energy store and brown adipocytes being potent energy-dissipaters through thermogenesis. Yet, little is known about factors differentially regulating the formation of white and brown fat cells. Members of the retinoblastoma protein family (pRB, p107, p130) have been implicated in the regulation of adipocyte differentiation, and expression and phosphorylation of the three retinoblastoma family proteins oscillate in a characteristic manner during differentiation of the white preadipocyte cell line 3T3-L1. We have recently demonstrated a surprising function of the retinoblastoma protein in the regulation of white versus brown adipocyte differentiation in vitro and possibly in vivo. Here we summarize the current knowledge on the retinoblastoma protein in fat cells, with particular emphasis on its potential role in adipocyte lineage commitment and differentiation.

AB - The differentiation of white and brown fat cells is controlled by a similar set of transcription factors, including PPAR? and C/EBP?. However, despite many similarities between the two types of fat cells, they carry out essentially opposite functions in vivo, with white adipocytes being the major energy store and brown adipocytes being potent energy-dissipaters through thermogenesis. Yet, little is known about factors differentially regulating the formation of white and brown fat cells. Members of the retinoblastoma protein family (pRB, p107, p130) have been implicated in the regulation of adipocyte differentiation, and expression and phosphorylation of the three retinoblastoma family proteins oscillate in a characteristic manner during differentiation of the white preadipocyte cell line 3T3-L1. We have recently demonstrated a surprising function of the retinoblastoma protein in the regulation of white versus brown adipocyte differentiation in vitro and possibly in vivo. Here we summarize the current knowledge on the retinoblastoma protein in fat cells, with particular emphasis on its potential role in adipocyte lineage commitment and differentiation.

M3 - Journal article

SN - 1538-4101

VL - 3

SP - 772

EP - 776

JO - Cell Cycle

JF - Cell Cycle

IS - 6

ER -