Novel mutations in leukotriene C4 synthase and risk of cardiovascular disease based on genotypes from 50,000 individuals

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    Abstract

    Atherosclerosis is an inflammatory condition where cysteinyl leukotrienes have been identified to play an important role. Furthermore, cysteinyl leukotrienes may also affect thrombus formation. Using prospective, cross-sectional and case-control designs, we tested the hypothesis that hitherto unknown genetic variation, likely to affect the function of leukotriene C(4) synthase, is associated with risk of venous thromboembolism, ischemic stroke and myocardial infarction.
    OriginalsprogEngelsk
    TidsskriftJournal of Thrombosis and Haemostasis
    Vol/bind8
    Udgave nummer8
    Sider (fra-til)1694-701
    Antal sider8
    ISSN1538-7933
    DOI
    StatusUdgivet - 1 aug. 2010

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