Nye retningslinjer for antibiotikadosering til patienter med nedsat nyrefunktion og patienter i haemodialyse

Claus Moser, Thomas Elung-Jensen, Niels Høiby

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    1 Citationer (Scopus)

    Abstract

    Dosing of antibiotics in patients with renal insufficiency has almost exclusively been based on pharmacokinetic (PK) parameters, whereas the different pharmacodynamic (PD) parameters of antibiotics have only been sparsely considered. This is not appropriate since antibiotics can be divided into two distinct groups: 1) Time-dependent and 2) Concentration (or total dose) dependent killing of bacteria. In this document revised recommendations based on PK/PD parameters are suggested.
    Udgivelsesdato: 2008-Feb-18
    Bidragets oversatte titelNew recommendations for antibiotic dosing in patients with renal insufficiency and in patients undergoing haemodialysis
    OriginalsprogDansk
    TidsskriftUgeskrift for læger
    Vol/bind170
    Udgave nummer8
    Sider (fra-til)629-32
    Antal sider3
    ISSN0041-5782
    StatusUdgivet - 2008

    Bibliografisk note

    Keywords: Anti-Bacterial Agents; Dose-Response Relationship, Drug; Humans; Microbial Sensitivity Tests; Renal Dialysis; Renal Insufficiency; Time Factors

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