Obstetric synthetic oxytocin use and subsequent hyperactivity/inattention problems in Danish children

Lonny Stokholm; Mette Juhl; Nicole N Lønfeldt; Susanne H Mikkelsen; Carsten Obel; Katrine Strandberg-Larsen

doi:10.1111/aogs.13344

Obstetric synthetic oxytocin use and subsequent hyperactivity/inattention problems in Danish children

Lonny Stokholm
, Mette Juhl
, Nicole N Lønfeldt
, Susanne H Mikkelsen
, Carsten Obel
, Katrine Strandberg-Larsen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

INTRODUCTION: The objective was to examine the association between obstetric synthetic oxytocin use and hyperactivity/inattention problems in offspring.

MATERIAL AND METHODS: We identified children born in 2000-2003, enrolled in the Danish National Birth Cohort, with data on the Strengths and Difficulties Questionnaire (SDQ) reported by parents at age 7 (n = 33 896) and age 11 (n = 27 561) and the children themselves around age 11 (n = 27 251). Information on oxytocin administration was provided in the Medical Birth Register. We estimated mean differences and odds ratios for childhood hyperactivity/inattention problems according to oxytocin exposure.

RESULTS: Synthetic oxytocin was administered in 26% of the deliveries. We did not find the use of synthetic oxytocin during birth to be associated with childhood hyperactivity/inattention problems, whether analyzed in linear or logistic regression models.

CONCLUSIONS: Our findings do not support any effects of obstetric use of synthetic oxytocin on hyperactivity/inattention problems in children when measured with the SDQ subscale at 7 or 11 years of age.

Originalsprog	Engelsk
Tidsskrift	Acta Obstetricia et Gynecologica Scandinavica
Vol/bind	97
Udgave nummer	7
Sider (fra-til)	880-889
Antal sider	10
ISSN	0001-6349
DOI	https://doi.org/10.1111/aogs.13344
Status	Udgivet - jul. 2018

Finansiering

This study was supported by a PhD grant from the Lundbeck Foundation and a grant from Aase and Ejnar Danielsen Foundation. The Danish National Birth Cohort was established with a generous grant from the Danish National Research Foundation. Additional support was obtained from the Danish Regional Committees, the Pharmacy Foundation, the Egmont Foundation, the March of Dimes Birth Defects Foundation, the Health Foundation and other minor grants. Follow up of mothers and children was supported by the Danish Medical Research Council (SSVF 0646, 271-08-0839/ 06-066023, O602-01042B, 0602-02738B), the Lundbeck Foundation (195/04, R100-A9193), The Innovation Fund Denmark (0603-00294B, 09-067124), the Nordea Foundation (02-2013-2014), Aarhus Ideas (AU R9-A959-13-S804), University of Copenhagen Strategic Grant (IFSV 2012) and the Danish Council for Independent Research (DFF – 4183-00594 and DFF – 4183-00152).

Adgang til dokumentet

10.1111/aogs.13344

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Citationsformater

@article{e0c3a0ec4e8a4590a01f9eeeecf5bb9e,

title = "Obstetric synthetic oxytocin use and subsequent hyperactivity/inattention problems in Danish children",

abstract = "INTRODUCTION: The objective was to examine the association between obstetric synthetic oxytocin use and hyperactivity/inattention problems in offspring.MATERIAL AND METHODS: We identified children born in 2000-2003, enrolled in the Danish National Birth Cohort, with data on the Strengths and Difficulties Questionnaire (SDQ) reported by parents at age 7 (n = 33 896) and age 11 (n = 27 561) and the children themselves around age 11 (n = 27 251). Information on oxytocin administration was provided in the Medical Birth Register. We estimated mean differences and odds ratios for childhood hyperactivity/inattention problems according to oxytocin exposure.RESULTS: Synthetic oxytocin was administered in 26\% of the deliveries. We did not find the use of synthetic oxytocin during birth to be associated with childhood hyperactivity/inattention problems, whether analyzed in linear or logistic regression models.CONCLUSIONS: Our findings do not support any effects of obstetric use of synthetic oxytocin on hyperactivity/inattention problems in children when measured with the SDQ subscale at 7 or 11 years of age.",

author = "Lonny Stokholm and Mette Juhl and L{\o}nfeldt, \{Nicole N\} and Mikkelsen, \{Susanne H\} and Carsten Obel and Katrine Strandberg-Larsen",

note = "{\textcopyright} 2018 Nordic Federation of Societies of Obstetrics and Gynecology.",

year = "2018",

month = jul,

doi = "10.1111/aogs.13344",

language = "English",

volume = "97",

pages = "880--889",

journal = "Acta Obstetricia et Gynecologica Scandinavica",

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TY - JOUR

T1 - Obstetric synthetic oxytocin use and subsequent hyperactivity/inattention problems in Danish children

AU - Stokholm, Lonny

AU - Juhl, Mette

AU - Lønfeldt, Nicole N

AU - Mikkelsen, Susanne H

AU - Obel, Carsten

AU - Strandberg-Larsen, Katrine

PY - 2018/7

Y1 - 2018/7

N2 - INTRODUCTION: The objective was to examine the association between obstetric synthetic oxytocin use and hyperactivity/inattention problems in offspring.MATERIAL AND METHODS: We identified children born in 2000-2003, enrolled in the Danish National Birth Cohort, with data on the Strengths and Difficulties Questionnaire (SDQ) reported by parents at age 7 (n = 33 896) and age 11 (n = 27 561) and the children themselves around age 11 (n = 27 251). Information on oxytocin administration was provided in the Medical Birth Register. We estimated mean differences and odds ratios for childhood hyperactivity/inattention problems according to oxytocin exposure.RESULTS: Synthetic oxytocin was administered in 26% of the deliveries. We did not find the use of synthetic oxytocin during birth to be associated with childhood hyperactivity/inattention problems, whether analyzed in linear or logistic regression models.CONCLUSIONS: Our findings do not support any effects of obstetric use of synthetic oxytocin on hyperactivity/inattention problems in children when measured with the SDQ subscale at 7 or 11 years of age.

AB - INTRODUCTION: The objective was to examine the association between obstetric synthetic oxytocin use and hyperactivity/inattention problems in offspring.MATERIAL AND METHODS: We identified children born in 2000-2003, enrolled in the Danish National Birth Cohort, with data on the Strengths and Difficulties Questionnaire (SDQ) reported by parents at age 7 (n = 33 896) and age 11 (n = 27 561) and the children themselves around age 11 (n = 27 251). Information on oxytocin administration was provided in the Medical Birth Register. We estimated mean differences and odds ratios for childhood hyperactivity/inattention problems according to oxytocin exposure.RESULTS: Synthetic oxytocin was administered in 26% of the deliveries. We did not find the use of synthetic oxytocin during birth to be associated with childhood hyperactivity/inattention problems, whether analyzed in linear or logistic regression models.CONCLUSIONS: Our findings do not support any effects of obstetric use of synthetic oxytocin on hyperactivity/inattention problems in children when measured with the SDQ subscale at 7 or 11 years of age.

U2 - 10.1111/aogs.13344

DO - 10.1111/aogs.13344

M3 - Journal article

C2 - 29574678

SN - 0001-6349

VL - 97

SP - 880

EP - 889

JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

IS - 7

ER -