Of mice and women: rodent models of placental malaria

Lars Hviid; Claudio R F Marinho; Trine Staalsoe; Carlos Penha-Gonçalves

doi:10.1016/j.pt.2010.04.010

Of mice and women: rodent models of placental malaria

Lars Hviid, Claudio R F Marinho, Trine Staalsoe, Carlos Penha-Gonçalves

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

31 Citationer (Scopus)

Abstract

Udgivelsesdato: 2010-Aug

Originalsprog	Engelsk
Tidsskrift	Trends in Parasitology
Vol/bind	26
Udgave nummer	8
Sider (fra-til)	412-9
Antal sider	7
ISSN	1471-4922
DOI	https://doi.org/10.1016/j.pt.2010.04.010
Status	Udgivet - 2010

Bibliografisk note

Adgang til dokumentet

10.1016/j.pt.2010.04.010

Citationsformater

@article{86893b20ab5311df928f000ea68e967b,

title = "Of mice and women: rodent models of placental malaria",

abstract = "Pregnant women are at increased malaria risk. The infections are characterized by placental accumulation of infected erythrocytes (IEs) with adverse consequences for mother and baby. Placental IE sequestration in the intervillous space is mediated by variant surface antigens (VSAs) selectively expressed in placental malaria (PM) and specific for chondroitin sulfate A (CSA). In Plasmodium falciparum, these VSA(PM) appear largely synonymous with the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family variant VAR2CSA. As rodent malaria parasites do not possess PfEMP1 homologs, the usefulness of experimental mouse PM models remains controversial. However, many features of murine and human PM are similar, including involvement of VSAs analogous to PfEMP1. It thus appears that rodent model studies can further the understanding of VSA-dependent malaria pathogenesis and immunity.",

author = "Lars Hviid and Marinho, {Claudio R F} and Trine Staalsoe and Carlos Penha-Gon{\c c}alves",

year = "2010",

doi = "10.1016/j.pt.2010.04.010",

language = "English",

volume = "26",

pages = "412--9",

journal = "Trends in Parasitology",

issn = "1471-4922",

publisher = "Elsevier Ltd. * Trends Journals",

number = "8",

}

TY - JOUR

T1 - Of mice and women: rodent models of placental malaria

AU - Hviid, Lars

AU - Marinho, Claudio R F

AU - Staalsoe, Trine

AU - Penha-Gonçalves, Carlos

PY - 2010

Y1 - 2010

N2 - Pregnant women are at increased malaria risk. The infections are characterized by placental accumulation of infected erythrocytes (IEs) with adverse consequences for mother and baby. Placental IE sequestration in the intervillous space is mediated by variant surface antigens (VSAs) selectively expressed in placental malaria (PM) and specific for chondroitin sulfate A (CSA). In Plasmodium falciparum, these VSA(PM) appear largely synonymous with the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family variant VAR2CSA. As rodent malaria parasites do not possess PfEMP1 homologs, the usefulness of experimental mouse PM models remains controversial. However, many features of murine and human PM are similar, including involvement of VSAs analogous to PfEMP1. It thus appears that rodent model studies can further the understanding of VSA-dependent malaria pathogenesis and immunity.

AB - Pregnant women are at increased malaria risk. The infections are characterized by placental accumulation of infected erythrocytes (IEs) with adverse consequences for mother and baby. Placental IE sequestration in the intervillous space is mediated by variant surface antigens (VSAs) selectively expressed in placental malaria (PM) and specific for chondroitin sulfate A (CSA). In Plasmodium falciparum, these VSA(PM) appear largely synonymous with the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family variant VAR2CSA. As rodent malaria parasites do not possess PfEMP1 homologs, the usefulness of experimental mouse PM models remains controversial. However, many features of murine and human PM are similar, including involvement of VSAs analogous to PfEMP1. It thus appears that rodent model studies can further the understanding of VSA-dependent malaria pathogenesis and immunity.

U2 - 10.1016/j.pt.2010.04.010

DO - 10.1016/j.pt.2010.04.010

M3 - Journal article

C2 - 20605743

VL - 26

SP - 412

EP - 419

JO - Trends in Parasitology

JF - Trends in Parasitology

SN - 1471-4922

IS - 8

ER -