@article{6e22c8b099fa11dd86a6000ea68e967b,
title = "Onset of transcription of the aminopeptidase N (leukemia antigen CD 13) gene at the crypt/villus transition zone during rabbit enterocyte differentiation.",
abstract = "The sequence of a cDNA clone (2.82 kbp) of rabbit intestinal aminopeptidase N (CD 13) is reported. Using the corresponding anti-sense RNA probe, the distribution of aminopeptidase N mRNA along the crypt/villus axis of the rabbit small intestine was studied by in situ hybridization. The aminopeptidase N gene is expressed along the whole length of the villus with a maximum at its base. Expression was not detected in the crypt cells. The distribution of aminopeptidase N mRNA correlates with the presence of active enzyme as monitored by histochemical staining. The results are compatible with onset of transcription of the aminopeptidase N gene at the crypt/villus transition zone during the enterocyte differentiation.",
author = "O Nor{\'e}n and E Dabelsteen and H{\o}yer, {P E} and H Sj{\"o}str{\"o}m and J{\o}rgen Olsen and Hansen, {Gert Helge}",
note = "Keywords: Amino Acid Sequence; Aminopeptidases; Animals; Antigens, CD13; Antigens, Differentiation, Myelomonocytic; Base Sequence; Blotting, Northern; Cell Differentiation; Gene Expression Regulation, Enzymologic; Intestine, Small; Microvilli; Molecular Sequence Data; Nucleic Acid Hybridization; RNA Probes; Rabbits; Transcription, Genetic",
year = "1989",
language = "English",
volume = "259",
pages = "107--12",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "JohnWiley & Sons Ltd",
number = "1",
}