@article{658d6d08a07849acbbfee072a713fc02,
title = "Optimising Controlled Human Malaria Infection Studies Using Cryopreserved P. falciparum Parasites Administered by Needle and Syringe",
abstract = "Controlled human malaria infection (CHMI) studies have become a routine tool to evaluate efficacy of candidate anti-malarial drugs and vaccines. To date, CHMI trials have mostly been conducted using the bite of infected mosquitoes, restricting the number of trial sites that can perform CHMI studies. Aseptic, cryopreserved P. falciparum sporozoites (PfSPZ Challenge) provide a potentially more accurate, reproducible and practical alternative, allowing a known number of sporozoites to be administered simply by injection.",
author = "Sheehy, {Susanne H} and Spencer, {Alexandra J} and Douglas, {Alexander D} and Sim, {B Kim Lee} and Longley, {Rhea J} and Edwards, {Nick J} and Poulton, {Ian D} and Domtila Kimani and Williams, {Andrew Richard} and Anagnostou, {Nicholas A} and Rachel Roberts and Simon Kerridge and Merryn Voysey and James, {Eric R} and Billingsley, {Peter F} and Anusha Gunasekera and Lawrie, {Alison M} and Hoffman, {Stephen L} and Hill, {Adrian V S}",
year = "2013",
doi = "10.1371/journal.pone.0065960",
language = "English",
volume = "8",
pages = "e65960",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "6",
}