TY - JOUR
T1 - Organ extraction of atrial natriuretic peptide (ANP) in man. Significance of sampling site
AU - Schütten, H J
AU - Henriksen, Jens Henrik Sahl
AU - Warberg, J
N1 - Keywords: Adult; Aged; Atrial Natriuretic Factor; Female; Half-Life; Humans; Intestines; Kidney; Leg; Liver; Lung; Male; Middle Aged; Radioimmunoassay
PY - 1987
Y1 - 1987
N2 - Arterial plasma immunoreactivity of endogenous human alpha-atrial natriuretic peptide (ANP) underwent mean 54%, 28% and 40% extraction during one passage through the circulation in the kidney (n = 12), liver-intestine (n = 14) and lower limb (n = 8), respectively, in supine fasting subjects with no detectable disease or subjects with cardiovascular or hepatic disorders of minor degree undergoing a haemodynamic investigation. No extraction was identified across the lungs as evaluated by the same concentration of ANP in pulmonary and femoral arteries (n = 7). The concentration of ANP in a superficial arm vein relative to the femoral artery varied considerably and extractions from 0% up to 58% were identified (mean 18%). The results suggest a high degree of, but only to some extent selective, extraction of ANP, which may account for its proposed short plasma half-life. Due to the different concentrations of ANP in various vascular beds, sampling site should be thoroughly specified.
AB - Arterial plasma immunoreactivity of endogenous human alpha-atrial natriuretic peptide (ANP) underwent mean 54%, 28% and 40% extraction during one passage through the circulation in the kidney (n = 12), liver-intestine (n = 14) and lower limb (n = 8), respectively, in supine fasting subjects with no detectable disease or subjects with cardiovascular or hepatic disorders of minor degree undergoing a haemodynamic investigation. No extraction was identified across the lungs as evaluated by the same concentration of ANP in pulmonary and femoral arteries (n = 7). The concentration of ANP in a superficial arm vein relative to the femoral artery varied considerably and extractions from 0% up to 58% were identified (mean 18%). The results suggest a high degree of, but only to some extent selective, extraction of ANP, which may account for its proposed short plasma half-life. Due to the different concentrations of ANP in various vascular beds, sampling site should be thoroughly specified.
M3 - Journal article
C2 - 2952390
SN - 0144-5979
VL - 7
SP - 125
EP - 132
JO - Clinical physiology (Oxford, England)
JF - Clinical physiology (Oxford, England)
IS - 2
ER -