Abstract
Originalsprog | Engelsk |
---|---|
Tidsskrift | Spinal Cord |
Vol/bind | 47 |
Udgave nummer | 8 |
Sider (fra-til) | 582-91 |
Antal sider | 10 |
ISSN | 1362-4393 |
DOI | |
Status | Udgivet - 2009 |
Bibliografisk note
Keywords: Clinical Trials as Topic; Humans; Outcome Assessment (Health Care); Spinal Cord Injuries; Treatment OutcomeAdgang til dokumentet
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I: Spinal Cord, Bind 47, Nr. 8, 2009, s. 582-91.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Outcome measures in spinal cord injury: recent assessments and recommendations for future directions
AU - Alexander, M S
AU - Anderson, K D
AU - Biering-Sørensen, Fin
AU - Blight, A R
AU - Brannon, R
AU - Bryce, T N
AU - Creasey, G
AU - Catz, A
AU - Curt, A
AU - Donovan, W
AU - Ditunno, J
AU - Ellaway, P
AU - Finnerup, N B
AU - Graves, D E
AU - Haynes, B A
AU - Heinemann, A W
AU - Jackson, A B
AU - Johnston, M V
AU - Kalpakjian, C Z
AU - Kleitman, N
AU - Krassioukov, A
AU - Krogh, K
AU - Lammertse, D
AU - Magasi, S
AU - Mulcahey, M J
AU - Schurch, B
AU - Sherwood, A
AU - Steeves, J D
AU - Stiens, S
AU - Tulsky, D S
AU - van Hedel, H J A
AU - Whiteneck, G
N1 - Keywords: Clinical Trials as Topic; Humans; Outcome Assessment (Health Care); Spinal Cord Injuries; Treatment Outcome
PY - 2009
Y1 - 2009
N2 - Study design:Review by the spinal cord outcomes partnership endeavor (SCOPE), which is a broad-based international consortium of scientists and clinical researchers representing academic institutions, industry, government agencies, not-for-profit organizations and foundations. Objectives:Assessment of current and evolving tools for evaluating human spinal cord injury (SCI) outcomes for both clinical diagnosis and clinical research studies. Methods:a framework for the appraisal of evidence of metric properties was used to examine outcome tools or tests for accuracy, sensitivity, reliability and validity for human SCI. Results:Imaging, neurological, functional, autonomic, sexual health, bladder/bowel, pain and psychosocial tools were evaluated. Several specific tools for human SCI studies have or are being developed to allow the more accurate determination for a clinically meaningful benefit (improvement in functional outcome or quality of life) being achieved as a result of a therapeutic intervention. Conclusion:Significant progress has been made, but further validation studies are required to identify the most appropriate tools for specific targets in a human SCI study or clinical trial.
AB - Study design:Review by the spinal cord outcomes partnership endeavor (SCOPE), which is a broad-based international consortium of scientists and clinical researchers representing academic institutions, industry, government agencies, not-for-profit organizations and foundations. Objectives:Assessment of current and evolving tools for evaluating human spinal cord injury (SCI) outcomes for both clinical diagnosis and clinical research studies. Methods:a framework for the appraisal of evidence of metric properties was used to examine outcome tools or tests for accuracy, sensitivity, reliability and validity for human SCI. Results:Imaging, neurological, functional, autonomic, sexual health, bladder/bowel, pain and psychosocial tools were evaluated. Several specific tools for human SCI studies have or are being developed to allow the more accurate determination for a clinically meaningful benefit (improvement in functional outcome or quality of life) being achieved as a result of a therapeutic intervention. Conclusion:Significant progress has been made, but further validation studies are required to identify the most appropriate tools for specific targets in a human SCI study or clinical trial.
U2 - 10.1038/sc.2009.18
DO - 10.1038/sc.2009.18
M3 - Journal article
C2 - 19381157
SN - 1362-4393
VL - 47
SP - 582
EP - 591
JO - Spinal Cord
JF - Spinal Cord
IS - 8
ER -