Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Ultrasound in Obstetrics and Gynecology |
| Vol/bind | 44 |
| Udgave nummer | 2 |
| Sider (fra-til) | 160-165 |
| ISSN | 0960-7692 |
| DOI | |
| Status | Udgivet - 2014 |
Bibliografisk note
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- Outcome of fetuses with short femur length detectedat second-trimester anomaly scanForlagets udgivne version, 603 KB
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I: Ultrasound in Obstetrics and Gynecology, Bind 44, Nr. 2, 2014, s. 160-165.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Outcome of fetuses with short femur length detected at second trimester malformation scan
T2 - a national survey
AU - Mathiesen, Jonathan M
AU - Aksglaede, Lise
AU - Skibsted, Lillian
AU - Petersen, O. B.
AU - Tabor, Ann
AU - Group., Danish Fetal Medicine Research
AU - Zingenberg, Helle Jeanette
N1 - This article is protected by copyright. All rights reserved.
PY - 2014
Y1 - 2014
N2 - ObjectiveTo assess the relationship between the finding of fetal femur diaphysis length (FL) below the 5th percentile at the second‐trimester scan and pregnancy outcome, in a population in which more than 90% of women attend first‐trimester screening.MethodsThis was a retrospective study of all Danish singleton pregnancies with a 17–22‐week anomaly scan between 1 January 2008 and 30 June 2011. Information on FL and gestational age (GA) at anomaly scan, on birth weight and GA at delivery and on chromosomal abnormalities was obtained from the Danish Fetal Medicine Database.ResultsShort FL was identified in 2718 (1.8%) of 147 766 fetuses and was present in 11 (16.2%) of the 68 fetuses affected by trisomy 21 (positive likelihood ratio (LR+) 8.8 (95% CI, 5.1–15.2)). Trisomy 13/18 and unbalanced autosomal structural abnormalities were also associated with a short FL in three (12.0%, LR+ 6.5 (95% CI, 2.3–18.9)) and eight (32.0%, LR+ 17.4 (95% CI, 9.8–30.9)) of the cases, respectively. The risk of a fetus having trisomy 21, trisomy 18, trisomy 13 or an unbalanced autosomal structural abnormality was 1 : 123 (95% CI, 79–192), given a short FL. Pregnancies with a fetus with short FL were more often affected by early preterm delivery (before 34 weeks) (5.6%; odds ratio (OR) = 4.2 (95% CI, 3.5–4.9)) and small‐for‐gestational‐age (SGA) infants (13.9%; OR = 4.3 (95% CI, 3.8–4.8)).ConclusionShort FL at the second‐trimester anomaly scan is associated with a significantly higher relative risk of chromosomal abnormalities, and a substantially higher absolute risk for SGA and early preterm delivery.
AB - ObjectiveTo assess the relationship between the finding of fetal femur diaphysis length (FL) below the 5th percentile at the second‐trimester scan and pregnancy outcome, in a population in which more than 90% of women attend first‐trimester screening.MethodsThis was a retrospective study of all Danish singleton pregnancies with a 17–22‐week anomaly scan between 1 January 2008 and 30 June 2011. Information on FL and gestational age (GA) at anomaly scan, on birth weight and GA at delivery and on chromosomal abnormalities was obtained from the Danish Fetal Medicine Database.ResultsShort FL was identified in 2718 (1.8%) of 147 766 fetuses and was present in 11 (16.2%) of the 68 fetuses affected by trisomy 21 (positive likelihood ratio (LR+) 8.8 (95% CI, 5.1–15.2)). Trisomy 13/18 and unbalanced autosomal structural abnormalities were also associated with a short FL in three (12.0%, LR+ 6.5 (95% CI, 2.3–18.9)) and eight (32.0%, LR+ 17.4 (95% CI, 9.8–30.9)) of the cases, respectively. The risk of a fetus having trisomy 21, trisomy 18, trisomy 13 or an unbalanced autosomal structural abnormality was 1 : 123 (95% CI, 79–192), given a short FL. Pregnancies with a fetus with short FL were more often affected by early preterm delivery (before 34 weeks) (5.6%; odds ratio (OR) = 4.2 (95% CI, 3.5–4.9)) and small‐for‐gestational‐age (SGA) infants (13.9%; OR = 4.3 (95% CI, 3.8–4.8)).ConclusionShort FL at the second‐trimester anomaly scan is associated with a significantly higher relative risk of chromosomal abnormalities, and a substantially higher absolute risk for SGA and early preterm delivery.
U2 - 10.1002/uog.13286
DO - 10.1002/uog.13286
M3 - Journal article
SN - 0960-7692
VL - 44
SP - 160
EP - 165
JO - Ultrasound in Obstetrics and Gynecology
JF - Ultrasound in Obstetrics and Gynecology
IS - 2
ER -