Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Climacteric |
| Vol/bind | 11 |
| Udgave nummer | 2 |
| Sider (fra-til) | 135-143 |
| Antal sider | 9 |
| ISSN | 1369-7137 |
| DOI | |
| Status | Udgivet - 2008 |
Adgang til dokumentet
Citationsformater
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS
Parallel Assessment of the Impact of Different Hormone Replacement Therapies on Breast Density by Radiologist- and Computer-Based Analyses of Mammograms. / Pettersen, Paola; Raundahl, Jakob; Loog, Marco; Nielsen, Mads; Tankó, L. B.; Christiansen, C.
I: Climacteric, Bind 11, Nr. 2, 2008, s. 135-143.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
}
TY - JOUR
T1 - Parallel Assessment of the Impact of Different Hormone Replacement Therapies on Breast Density by Radiologist- and Computer-Based Analyses of Mammograms
AU - Pettersen, Paola
AU - Raundahl, Jakob
AU - Loog, Marco
AU - Nielsen, Mads
AU - Tankó, L. B.
AU - Christiansen, C.
PY - 2008
Y1 - 2008
N2 - OBJECTIVES: First, to compare the impact of nasally and orally dosed estradiol on breast density; second, to investigate the utility of computer-based automated approaches to the assessment of breast density with reference to traditional methods.METHODS: Digitized images from two 2-year, randomized, placebo-controlled trials formed the basis of the present post hoc analysis. Active treatments were 1 mg estradiol continuously combined with 0.125 mg trimegestone (oral hormone replacement therapy, HRT) or low-dose (150 or 300 microg estradiol) nasal estradiol cyclically combined with 200 mg micronized progesterone (nasal HRT). The effects on breast density were assessed by a radiologist, providing the BI-RADS score and the interactive threshold, and by a computer-based approach, providing the measure of stripiness and the HRT-effect specific measure of breast density.RESULTS: In the oral HRT trial, active treatment induced a significant increase in breast density, which was consistent in all methods used (all p < 0.05). In contrast, none of the methods detected significant changes in women receiving nasal HRT. The sensitivity of automated methods to discriminate HRT- from placebo-treated women was equal or better than the sensitivity of methods performed by the radiologist.CONCLUSIONS: The markedly different pharmacokinetic profile of nasal estrogen seems to be associated with better breast safety. Automated computer-based analysis of digitized mammograms provides a sensitive measure of changes in breast density induced by hormones and could serve as a useful tool in future clinical trials.
AB - OBJECTIVES: First, to compare the impact of nasally and orally dosed estradiol on breast density; second, to investigate the utility of computer-based automated approaches to the assessment of breast density with reference to traditional methods.METHODS: Digitized images from two 2-year, randomized, placebo-controlled trials formed the basis of the present post hoc analysis. Active treatments were 1 mg estradiol continuously combined with 0.125 mg trimegestone (oral hormone replacement therapy, HRT) or low-dose (150 or 300 microg estradiol) nasal estradiol cyclically combined with 200 mg micronized progesterone (nasal HRT). The effects on breast density were assessed by a radiologist, providing the BI-RADS score and the interactive threshold, and by a computer-based approach, providing the measure of stripiness and the HRT-effect specific measure of breast density.RESULTS: In the oral HRT trial, active treatment induced a significant increase in breast density, which was consistent in all methods used (all p < 0.05). In contrast, none of the methods detected significant changes in women receiving nasal HRT. The sensitivity of automated methods to discriminate HRT- from placebo-treated women was equal or better than the sensitivity of methods performed by the radiologist.CONCLUSIONS: The markedly different pharmacokinetic profile of nasal estrogen seems to be associated with better breast safety. Automated computer-based analysis of digitized mammograms provides a sensitive measure of changes in breast density induced by hormones and could serve as a useful tool in future clinical trials.
U2 - 10.1080/13697130801930385
DO - 10.1080/13697130801930385
M3 - Journal article
C2 - 18365856
VL - 11
SP - 135
EP - 143
JO - Climacteric
JF - Climacteric
SN - 1369-7137
IS - 2
ER -