Abstract
Originalsprog | Engelsk |
---|---|
Tidsskrift | Magnetic Resonance in Medicine |
Vol/bind | 62 |
Udgave nummer | 4 |
Sider (fra-til) | 1055-9 |
Antal sider | 4 |
ISSN | 0740-3194 |
DOI | |
Status | Udgivet - 2009 |
Bibliografisk note
(c) 2009 Wiley-Liss, Inc.Adgang til dokumentet
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Partial volume effect (PVE) on the arterial input function (AIF) in T1-weighted perfusion imaging and limitations of the multiplicative rescaling approach. / Hansen, Adam Espe; Pedersen, Henrik; Rostrup, Egill; Larsson, Henrik B W; Hansen, Adam E; Pedersen, Henrik; Rostrup, Egill; Larsson, Henrik B W.
I: Magnetic Resonance in Medicine, Bind 62, Nr. 4, 2009, s. 1055-9.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Partial volume effect (PVE) on the arterial input function (AIF) in T1-weighted perfusion imaging and limitations of the multiplicative rescaling approach
AU - Hansen, Adam Espe
AU - Pedersen, Henrik
AU - Rostrup, Egill
AU - Larsson, Henrik B W
AU - Hansen, Adam E
AU - Pedersen, Henrik
AU - Rostrup, Egill
AU - Larsson, Henrik B W
N1 - Keywords: Algorithms; Artifacts; Brain; Cerebrovascular Circulation; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Imaging, Three-Dimensional; Magnetic Resonance Angiography; Reproducibility of Results; Sensitivity and Specificity
PY - 2009
Y1 - 2009
N2 - The partial volume effect (PVE) on the arterial input function (AIF) remains a major obstacle to absolute quantification of cerebral blood flow (CBF) using MRI. This study evaluates the validity and performance of a commonly used multiplicative rescaling of the AIF to correct for the PVE. In a group of six patients, perfusion imaging was performed using a T(1)-weighted approach that minimizes confounding susceptibility artifacts. Various degrees of PVE were induced on the AIF and subsequently corrected using four different schemes of multiplicative AIF rescaling. Our results show that a multiplicative rescaling is not always applicable and can introduce a CBF bias. An easily measurable quantity denoted the tissue signal fraction (TSF) is proposed as a measure of the applicability of a multiplicative rescaling. For the present CBF quantification method, a TSF of <0.4 results in a CBF bias <15% after AIF rescaling.
AB - The partial volume effect (PVE) on the arterial input function (AIF) remains a major obstacle to absolute quantification of cerebral blood flow (CBF) using MRI. This study evaluates the validity and performance of a commonly used multiplicative rescaling of the AIF to correct for the PVE. In a group of six patients, perfusion imaging was performed using a T(1)-weighted approach that minimizes confounding susceptibility artifacts. Various degrees of PVE were induced on the AIF and subsequently corrected using four different schemes of multiplicative AIF rescaling. Our results show that a multiplicative rescaling is not always applicable and can introduce a CBF bias. An easily measurable quantity denoted the tissue signal fraction (TSF) is proposed as a measure of the applicability of a multiplicative rescaling. For the present CBF quantification method, a TSF of <0.4 results in a CBF bias <15% after AIF rescaling.
U2 - 10.1002/mrm.22098
DO - 10.1002/mrm.22098
M3 - Journal article
C2 - 19672948
VL - 62
SP - 1055
EP - 1059
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
SN - 0740-3194
IS - 4
ER -