Pentraxin 3 in the cerebrospinal fluid during central nervous system infections: A retrospective cohort study

Martin Munthe Thomsen; Lea Munthe-Fog; Pelle Trier Petersen; Thore Hillig; Lennart Jan Friis-Hansen; Casper Roed; Zitta Barrella Harboe; Christian Thomas Brandt

doi:10.1371/journal.pone.0282004

Pentraxin 3 in the cerebrospinal fluid during central nervous system infections: A retrospective cohort study

Martin Munthe Thomsen^*, Lea Munthe-Fog, Pelle Trier Petersen, Thore Hillig, Lennart Jan Friis-Hansen, Casper Roed, Zitta Barrella Harboe, Christian Thomas Brandt

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

2 Citationer (Scopus)

15 Downloads (Pure)

Abstract

The present study describes diagnostic and prognostic abilities of Cerebrospinal fluid (CSF) Pentraxin 3 (PTX3) in central nervous system (CNS) infections. CSF PTX3 was measured retrospectively from 174 patients admitted under suspicion of CNS infection. Medians, ROC curves and Youdens index was calculated. CSF PTX3 was significantly higher among all CNS infections and undetectable in most of the patients in the control group, and significantly higher in bacterial infections compared to viral and Lyme infections. No association was found between CSF PTX3 and Glasgow Outcome Score. PTX3 in the CSF can distinguish bacterial infection from viral and Lyme infections and non-CNS infections. Highest levels were found in bacterial meningitis. No prognostic abilities were found.

Originalsprog	Engelsk
Artikelnummer	e0282004
Tidsskrift	PLoS ONE
Vol/bind	18
Udgave nummer	3 March
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0282004
Status	Udgivet - 2023

Bibliografisk note

Funding Information:
Receiver of grant: MMT Funder: Nordsjællands Hospital Url: https://www. nordsjaellandshospital.dk/forskning/Sider/default. aspx The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Publisher Copyright:
© 2023 Thomsen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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10.1371/journal.pone.0282004Licens: CC BY

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Citationsformater

Pentraxin 3 in the cerebrospinal fluid during central nervous system infections : A retrospective cohort study. / Thomsen, Martin Munthe; Munthe-Fog, Lea; Trier Petersen, Pelle; Hillig, Thore; Friis-Hansen, Lennart Jan; Roed, Casper; Harboe, Zitta Barrella ; Brandt, Christian Thomas.

I: PLoS ONE, Bind 18, Nr. 3 March, e0282004, 2023.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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abstract = "The present study describes diagnostic and prognostic abilities of Cerebrospinal fluid (CSF) Pentraxin 3 (PTX3) in central nervous system (CNS) infections. CSF PTX3 was measured retrospectively from 174 patients admitted under suspicion of CNS infection. Medians, ROC curves and Youdens index was calculated. CSF PTX3 was significantly higher among all CNS infections and undetectable in most of the patients in the control group, and significantly higher in bacterial infections compared to viral and Lyme infections. No association was found between CSF PTX3 and Glasgow Outcome Score. PTX3 in the CSF can distinguish bacterial infection from viral and Lyme infections and non-CNS infections. Highest levels were found in bacterial meningitis. No prognostic abilities were found.",

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AU - Thomsen, Martin Munthe

AU - Munthe-Fog, Lea

AU - Trier Petersen, Pelle

AU - Hillig, Thore

AU - Friis-Hansen, Lennart Jan

AU - Roed, Casper

AU - Harboe, Zitta Barrella

AU - Brandt, Christian Thomas

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N2 - The present study describes diagnostic and prognostic abilities of Cerebrospinal fluid (CSF) Pentraxin 3 (PTX3) in central nervous system (CNS) infections. CSF PTX3 was measured retrospectively from 174 patients admitted under suspicion of CNS infection. Medians, ROC curves and Youdens index was calculated. CSF PTX3 was significantly higher among all CNS infections and undetectable in most of the patients in the control group, and significantly higher in bacterial infections compared to viral and Lyme infections. No association was found between CSF PTX3 and Glasgow Outcome Score. PTX3 in the CSF can distinguish bacterial infection from viral and Lyme infections and non-CNS infections. Highest levels were found in bacterial meningitis. No prognostic abilities were found.

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