Perceived stress and risk of colorectal cancer in men and women: a prospective cohort study

N R Nielsen; T S Kristensen; Katrine Strandberg-Larsen; Z-F Zhang; P Schnohr; M Grønbaek

doi:10.1111/j.1365-2796.2007.01826.x

Perceived stress and risk of colorectal cancer in men and women: a prospective cohort study

N R Nielsen, T S Kristensen, Katrine Strandberg-Larsen, Z-F Zhang, P Schnohr, M Grønbaek

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

14 Citationer (Scopus)

Abstract

Udgivelsesdato: 2008-Feb

Originalsprog	Engelsk
Tidsskrift	Journal of Internal Medicine
Vol/bind	263
Udgave nummer	2
Sider (fra-til)	192-202
Antal sider	10
ISSN	0954-6820
DOI	https://doi.org/10.1111/j.1365-2796.2007.01826.x
Status	Udgivet - 2008

Bibliografisk note

Keywords: Adult; Aged; Aged, 80 and over; Cohort Studies; Colorectal Neoplasms; Denmark; Female; Humans; Male; Middle Aged; Proportional Hazards Models; Prospective Studies; Stress, Psychological

Adgang til dokumentet

10.1111/j.1365-2796.2007.01826.x

Citationsformater

@article{4881ef40de3911ddb5fc000ea68e967b,

title = "Perceived stress and risk of colorectal cancer in men and women: a prospective cohort study",

abstract = "OBJECTIVE: We aim to assess the relationship between stress and risk of primary colorectal cancer in men and women. DESIGN: A prospective cohort study. SETTING: The Copenhagen City Heart Study, Denmark. SUBJECTS: A total of 6488 women and 5426 men were included in the study. The participants were asked about intensity and frequency of stress at baseline in 1981-1983 and were followed until the end of 2000 in the Danish Cancer Registry. Less than 0.1% was lost to follow-up. MAIN OUTCOME MEASURES: First time incidence of primary colorectal cancer. RESULTS: During follow-up 162 women and 166 men were diagnosed with colorectal cancer. Women with moderate and high stress intensity had a hazard ratio of 0.60 (95% CI: 0.37-0.98) and 0.52 (0.23-1.14) for colorectal cancer, respectively, compared to women with no stress. For colon cancer, a one-unit increase on a seven-point stress-score was associated with an 11% lower incidence of the disease (HR = 0.89, 95% CI: 0.81-0.99) amongst women. There was no consistent evidence of an association between stress and colorectal cancer in men. CONCLUSION: Perceived stress was associated with lower risk of particularly colon cancer in women, whilst there was no clear relationship between stress and colorectal cancer in men.",

author = "Nielsen, {N R} and Kristensen, {T S} and Katrine Strandberg-Larsen and Z-F Zhang and P Schnohr and M Gr{\o}nbaek",

note = "Keywords: Adult; Aged; Aged, 80 and over; Cohort Studies; Colorectal Neoplasms; Denmark; Female; Humans; Male; Middle Aged; Proportional Hazards Models; Prospective Studies; Stress, Psychological",

year = "2008",

doi = "10.1111/j.1365-2796.2007.01826.x",

language = "English",

volume = "263",

pages = "192--202",

journal = "Acta Medica Scandinavica",

issn = "0955-7873",

publisher = "Wiley-Blackwell",

number = "2",

}

TY - JOUR

T1 - Perceived stress and risk of colorectal cancer in men and women: a prospective cohort study

AU - Nielsen, N R

AU - Kristensen, T S

AU - Strandberg-Larsen, Katrine

AU - Zhang, Z-F

AU - Schnohr, P

AU - Grønbaek, M

N1 - Keywords: Adult; Aged; Aged, 80 and over; Cohort Studies; Colorectal Neoplasms; Denmark; Female; Humans; Male; Middle Aged; Proportional Hazards Models; Prospective Studies; Stress, Psychological

PY - 2008

Y1 - 2008

N2 - OBJECTIVE: We aim to assess the relationship between stress and risk of primary colorectal cancer in men and women. DESIGN: A prospective cohort study. SETTING: The Copenhagen City Heart Study, Denmark. SUBJECTS: A total of 6488 women and 5426 men were included in the study. The participants were asked about intensity and frequency of stress at baseline in 1981-1983 and were followed until the end of 2000 in the Danish Cancer Registry. Less than 0.1% was lost to follow-up. MAIN OUTCOME MEASURES: First time incidence of primary colorectal cancer. RESULTS: During follow-up 162 women and 166 men were diagnosed with colorectal cancer. Women with moderate and high stress intensity had a hazard ratio of 0.60 (95% CI: 0.37-0.98) and 0.52 (0.23-1.14) for colorectal cancer, respectively, compared to women with no stress. For colon cancer, a one-unit increase on a seven-point stress-score was associated with an 11% lower incidence of the disease (HR = 0.89, 95% CI: 0.81-0.99) amongst women. There was no consistent evidence of an association between stress and colorectal cancer in men. CONCLUSION: Perceived stress was associated with lower risk of particularly colon cancer in women, whilst there was no clear relationship between stress and colorectal cancer in men.

AB - OBJECTIVE: We aim to assess the relationship between stress and risk of primary colorectal cancer in men and women. DESIGN: A prospective cohort study. SETTING: The Copenhagen City Heart Study, Denmark. SUBJECTS: A total of 6488 women and 5426 men were included in the study. The participants were asked about intensity and frequency of stress at baseline in 1981-1983 and were followed until the end of 2000 in the Danish Cancer Registry. Less than 0.1% was lost to follow-up. MAIN OUTCOME MEASURES: First time incidence of primary colorectal cancer. RESULTS: During follow-up 162 women and 166 men were diagnosed with colorectal cancer. Women with moderate and high stress intensity had a hazard ratio of 0.60 (95% CI: 0.37-0.98) and 0.52 (0.23-1.14) for colorectal cancer, respectively, compared to women with no stress. For colon cancer, a one-unit increase on a seven-point stress-score was associated with an 11% lower incidence of the disease (HR = 0.89, 95% CI: 0.81-0.99) amongst women. There was no consistent evidence of an association between stress and colorectal cancer in men. CONCLUSION: Perceived stress was associated with lower risk of particularly colon cancer in women, whilst there was no clear relationship between stress and colorectal cancer in men.

U2 - 10.1111/j.1365-2796.2007.01826.x

DO - 10.1111/j.1365-2796.2007.01826.x

M3 - Journal article

C2 - 18226096

VL - 263

SP - 192

EP - 202

JO - Acta Medica Scandinavica

JF - Acta Medica Scandinavica

SN - 0955-7873

IS - 2

ER -