Peri-ictal changes of cortical excitability in children suffering from migraine without aura

Michael Siniatchkin; Anna-Lena Reich; Alex J Shepherd; Andreas van Baalen; Hartwig Roman Siebner; Ulrich Stephani

doi:10.1016/j.pain.2009.08.028

Peri-ictal changes of cortical excitability in children suffering from migraine without aura

Michael Siniatchkin, Anna-Lena Reich, Alex J Shepherd, Andreas van Baalen, Hartwig Roman Siebner, Ulrich Stephani

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

47 Citationer (Scopus)

Abstract

Udgivelsesdato: 2009-Dec

Originalsprog	Engelsk
Tidsskrift	Pain
Vol/bind	147
Udgave nummer	1-3
Sider (fra-til)	132-40
Antal sider	8
ISSN	0304-3959
DOI	https://doi.org/10.1016/j.pain.2009.08.028
Status	Udgivet - 2009

Bibliografisk note

Keywords: Adolescent; Analysis of Variance; Case-Control Studies; Cerebral Cortex; Child; Databases, Factual; Electric Stimulation; Evoked Potentials, Motor; Female; Humans; Male; Migraine without Aura; Motion Perception; Statistics as Topic; Time Factors; Transcranial Magnetic Stimulation; Visual Perception

Adgang til dokumentet

10.1016/j.pain.2009.08.028

Citationsformater

@article{ed9f5f70ab5c11df928f000ea68e967b,

title = "Peri-ictal changes of cortical excitability in children suffering from migraine without aura",

abstract = "In adult patients with migraine, transcranial magnetic stimulation (TMS) has been used to examine cortical excitability between attacks, but there have been discrepant results. No TMS study has examined cortical excitability in children or adolescents with migraine. Here, we employed TMS to study regional excitability of the occipital (phosphene threshold [PT] and suppression of visual perception) and motor (resting motor threshold and cortical silent period) cortex in ten children suffering from migraine without aura and ten healthy age-matched controls. Patients were studied 1-2 days before and after a migraine attack as well as during the inter-migraine interval. The motion aftereffect was also investigated at each time-point as an index of cortical reactivity to moving visual stimuli. Migraineurs had lower PTs compared to healthy participants at each time-point, indicating increased occipital excitability. This increase in occipital excitability was attenuated 1-2 days before a migraine attack as indicated by a relative increase in PTs. The increase in PTs before the next attack was associated with a stronger TMS-induced suppression of visual perception and a prolongation of the motion aftereffect. Motor cortex excitability was not altered in patients and did not change during the migraine cycle. These findings show that pediatric migraine without aura is associated with a systematic shift in occipital excitability preceding the migraine attack. Similar systematic fluctuations in cortical excitability might be present in adult migraineurs and may reflect either a protective mechanism or an abnormal decrease in cortical excitability that predisposes an individual to a migraine attack.",

author = "Michael Siniatchkin and Anna-Lena Reich and Shepherd, {Alex J} and {van Baalen}, Andreas and Siebner, {Hartwig Roman} and Ulrich Stephani",

note = "Keywords: Adolescent; Analysis of Variance; Case-Control Studies; Cerebral Cortex; Child; Databases, Factual; Electric Stimulation; Evoked Potentials, Motor; Female; Humans; Male; Migraine without Aura; Motion Perception; Statistics as Topic; Time Factors; Transcranial Magnetic Stimulation; Visual Perception",

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TY - JOUR

T1 - Peri-ictal changes of cortical excitability in children suffering from migraine without aura

AU - Siniatchkin, Michael

AU - Reich, Anna-Lena

AU - Shepherd, Alex J

AU - van Baalen, Andreas

AU - Siebner, Hartwig Roman

AU - Stephani, Ulrich

N1 - Keywords: Adolescent; Analysis of Variance; Case-Control Studies; Cerebral Cortex; Child; Databases, Factual; Electric Stimulation; Evoked Potentials, Motor; Female; Humans; Male; Migraine without Aura; Motion Perception; Statistics as Topic; Time Factors; Transcranial Magnetic Stimulation; Visual Perception

PY - 2009

Y1 - 2009

N2 - In adult patients with migraine, transcranial magnetic stimulation (TMS) has been used to examine cortical excitability between attacks, but there have been discrepant results. No TMS study has examined cortical excitability in children or adolescents with migraine. Here, we employed TMS to study regional excitability of the occipital (phosphene threshold [PT] and suppression of visual perception) and motor (resting motor threshold and cortical silent period) cortex in ten children suffering from migraine without aura and ten healthy age-matched controls. Patients were studied 1-2 days before and after a migraine attack as well as during the inter-migraine interval. The motion aftereffect was also investigated at each time-point as an index of cortical reactivity to moving visual stimuli. Migraineurs had lower PTs compared to healthy participants at each time-point, indicating increased occipital excitability. This increase in occipital excitability was attenuated 1-2 days before a migraine attack as indicated by a relative increase in PTs. The increase in PTs before the next attack was associated with a stronger TMS-induced suppression of visual perception and a prolongation of the motion aftereffect. Motor cortex excitability was not altered in patients and did not change during the migraine cycle. These findings show that pediatric migraine without aura is associated with a systematic shift in occipital excitability preceding the migraine attack. Similar systematic fluctuations in cortical excitability might be present in adult migraineurs and may reflect either a protective mechanism or an abnormal decrease in cortical excitability that predisposes an individual to a migraine attack.

AB - In adult patients with migraine, transcranial magnetic stimulation (TMS) has been used to examine cortical excitability between attacks, but there have been discrepant results. No TMS study has examined cortical excitability in children or adolescents with migraine. Here, we employed TMS to study regional excitability of the occipital (phosphene threshold [PT] and suppression of visual perception) and motor (resting motor threshold and cortical silent period) cortex in ten children suffering from migraine without aura and ten healthy age-matched controls. Patients were studied 1-2 days before and after a migraine attack as well as during the inter-migraine interval. The motion aftereffect was also investigated at each time-point as an index of cortical reactivity to moving visual stimuli. Migraineurs had lower PTs compared to healthy participants at each time-point, indicating increased occipital excitability. This increase in occipital excitability was attenuated 1-2 days before a migraine attack as indicated by a relative increase in PTs. The increase in PTs before the next attack was associated with a stronger TMS-induced suppression of visual perception and a prolongation of the motion aftereffect. Motor cortex excitability was not altered in patients and did not change during the migraine cycle. These findings show that pediatric migraine without aura is associated with a systematic shift in occipital excitability preceding the migraine attack. Similar systematic fluctuations in cortical excitability might be present in adult migraineurs and may reflect either a protective mechanism or an abnormal decrease in cortical excitability that predisposes an individual to a migraine attack.

U2 - 10.1016/j.pain.2009.08.028

DO - 10.1016/j.pain.2009.08.028

M3 - Journal article

C2 - 19796876

SN - 0304-3959

VL - 147

SP - 132

EP - 140

JO - Pain

JF - Pain

IS - 1-3

ER -