TY - JOUR
T1 - PGC-1α Is Required for Exercise- and Exercise Training-Induced UCP1 Up-Regulation in Mouse White Adipose Tissue.
AU - Jørgensen, Stine Ringholm
AU - Grunnet Knudsen, Jakob
AU - Leick, Lotte
AU - Lundgaard, Anders
AU - Munk Nielsen, Maja
AU - Pilegaard, Henriette
PY - 2013
Y1 - 2013
N2 - The aim of the present study was to test the hypotheses that 1) a single exercise bout increases UCP1 mRNA in both inguinal (i)WAT and epididymal (e)WAT, 2) UCP1 expression and responsiveness to exercise are different in iWAT and eWAT, 3) PGC-1α determines the basal levels of UCP1 and PRDM16 in WAT and 4) exercise and exercise training regulate UCP1 and PRDM16 expression in WAT in a PGC-1α-dependent manner.
AB - The aim of the present study was to test the hypotheses that 1) a single exercise bout increases UCP1 mRNA in both inguinal (i)WAT and epididymal (e)WAT, 2) UCP1 expression and responsiveness to exercise are different in iWAT and eWAT, 3) PGC-1α determines the basal levels of UCP1 and PRDM16 in WAT and 4) exercise and exercise training regulate UCP1 and PRDM16 expression in WAT in a PGC-1α-dependent manner.
U2 - 10.1371/journal.pone.0064123
DO - 10.1371/journal.pone.0064123
M3 - Journal article
C2 - 23717545
VL - 8
SP - 1
EP - 6
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 5
M1 - e64123
ER -