Photodynamic therapy of necrobiosis lipoidica--a multicenter study of 18 patients

C Berking; J Hegyi; P Arenberger; T Ruzicka; G B E Jemec

doi:10.1159/000182259

Photodynamic therapy of necrobiosis lipoidica--a multicenter study of 18 patients

C Berking, J Hegyi, P Arenberger, T Ruzicka, G B E Jemec

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

53 Citationer (Scopus)

Abstract

Udgivelsesdato: 2009-null

Originalsprog	Engelsk
Tidsskrift	Dermatology
Vol/bind	218
Udgave nummer	2
Sider (fra-til)	136-9
Antal sider	4
ISSN	1018-8665
DOI	https://doi.org/10.1159/000182259
Status	Udgivet - 2008

Bibliografisk note

Adgang til dokumentet

10.1159/000182259

Citationsformater

@article{cb3041d0747411df928f000ea68e967b,

title = "Photodynamic therapy of necrobiosis lipoidica--a multicenter study of 18 patients",

abstract = "BACKGROUND: Necrobiosis lipoidica (NL) is a granulomatous skin disease of unknown origin, and no reliably effective treatment option exists to handle this often disfiguring disease. Recently, a patient with long-lasting NL was reported to be cured by topical photodynamic therapy (PDT). OBJECTIVE: To evaluate the overall potential of PDT in the treatment of NL on the lower legs. METHODS: Retrospective study of 18 patients (aged 16-62 years) from 3 European university departments of dermatology treated with PDT for NL. Methyl aminolevulinate or 5-aminolevulinic acid were used as topically applied photosensitizers. Illumination followed with red light-emitting diode light. RESULTS: Complete response was seen in 1/18 patients after 9 PDT cycles, and partial response in 6/18 patients (2-14 PDT cycles) giving an overall response rate of 39% (7/18). CONCLUSION: Although almost 40% of the cases showed some degree of response, PDT cannot currently be recommended as first-line therapy of NL. Subpopulations of therapy-resistant NL patients may, however, benefit from PDT.",

author = "C Berking and J Hegyi and P Arenberger and T Ruzicka and Jemec, {G B E}",

note = "Keywords: Administration, Cutaneous; Adolescent; Adult; Aminolevulinic Acid; Czech Republic; Denmark; Female; Germany; Humans; Leg; Male; Middle Aged; Necrobiosis Lipoidica; Photochemotherapy; Photosensitizing Agents; Retrospective Studies; Treatment Outcome",

year = "2008",

doi = "10.1159/000182259",

language = "English",

volume = "218",

pages = "136--9",

journal = "Dermatology",

issn = "1018-8665",

publisher = "S Karger AG",

number = "2",

}

TY - JOUR

T1 - Photodynamic therapy of necrobiosis lipoidica--a multicenter study of 18 patients

AU - Berking, C

AU - Hegyi, J

AU - Arenberger, P

AU - Ruzicka, T

AU - Jemec, G B E

N1 - Keywords: Administration, Cutaneous; Adolescent; Adult; Aminolevulinic Acid; Czech Republic; Denmark; Female; Germany; Humans; Leg; Male; Middle Aged; Necrobiosis Lipoidica; Photochemotherapy; Photosensitizing Agents; Retrospective Studies; Treatment Outcome

PY - 2008

Y1 - 2008

N2 - BACKGROUND: Necrobiosis lipoidica (NL) is a granulomatous skin disease of unknown origin, and no reliably effective treatment option exists to handle this often disfiguring disease. Recently, a patient with long-lasting NL was reported to be cured by topical photodynamic therapy (PDT). OBJECTIVE: To evaluate the overall potential of PDT in the treatment of NL on the lower legs. METHODS: Retrospective study of 18 patients (aged 16-62 years) from 3 European university departments of dermatology treated with PDT for NL. Methyl aminolevulinate or 5-aminolevulinic acid were used as topically applied photosensitizers. Illumination followed with red light-emitting diode light. RESULTS: Complete response was seen in 1/18 patients after 9 PDT cycles, and partial response in 6/18 patients (2-14 PDT cycles) giving an overall response rate of 39% (7/18). CONCLUSION: Although almost 40% of the cases showed some degree of response, PDT cannot currently be recommended as first-line therapy of NL. Subpopulations of therapy-resistant NL patients may, however, benefit from PDT.

AB - BACKGROUND: Necrobiosis lipoidica (NL) is a granulomatous skin disease of unknown origin, and no reliably effective treatment option exists to handle this often disfiguring disease. Recently, a patient with long-lasting NL was reported to be cured by topical photodynamic therapy (PDT). OBJECTIVE: To evaluate the overall potential of PDT in the treatment of NL on the lower legs. METHODS: Retrospective study of 18 patients (aged 16-62 years) from 3 European university departments of dermatology treated with PDT for NL. Methyl aminolevulinate or 5-aminolevulinic acid were used as topically applied photosensitizers. Illumination followed with red light-emitting diode light. RESULTS: Complete response was seen in 1/18 patients after 9 PDT cycles, and partial response in 6/18 patients (2-14 PDT cycles) giving an overall response rate of 39% (7/18). CONCLUSION: Although almost 40% of the cases showed some degree of response, PDT cannot currently be recommended as first-line therapy of NL. Subpopulations of therapy-resistant NL patients may, however, benefit from PDT.

U2 - 10.1159/000182259

DO - 10.1159/000182259

M3 - Journal article

C2 - 19060464

VL - 218

SP - 136

EP - 139

JO - Dermatology

JF - Dermatology

SN - 1018-8665

IS - 2

ER -