Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Scandinavian Journal of Medicine & Science in Sports |
| Vol/bind | 18 |
| Udgave nummer | 5 |
| Sider (fra-til) | 557-564 |
| Antal sider | 8 |
| ISSN | 0905-7188 |
| DOI | |
| Status | Udgivet - 2008 |
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Physical activity counteracts increased whole-body protein breakdown in chronic obstructive pulmonary disease patients. / Petersen, A.M.W.; Mittendorfer, Bettina; Magkos, Faidon; Iversen, M.; Pedersen, Bente Klarlund.
I: Scandinavian Journal of Medicine & Science in Sports, Bind 18, Nr. 5, 2008, s. 557-564.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Physical activity counteracts increased whole-body protein breakdown in chronic obstructive pulmonary disease patients
AU - Petersen, A.M.W.
AU - Mittendorfer, Bettina
AU - Magkos, Faidon
AU - Iversen, M.
AU - Pedersen, Bente Klarlund
N1 - (Ekstern)
PY - 2008
Y1 - 2008
N2 - Chronic obstructive pulmonary disease (COPD) is associated with increased whole body protein breakdown and low-grade systemic inflammation. We aimed to determine if physical training of patients with COPD induces anti-inflammatory effects and decreases whole-body protein breakdown. Nineteen subjects with severe (FEV1=31±1) COPD were randomized into a training group (n=9) and a control group (n=10). Twenty healthy subjects were studied for baseline comparison. The “COPD training” group participated in an outpatient rehabilitation program consisting of endurance training (walking at 85% of VO2max) twice weekly for 7 weeks plus daily home-based training. Maximum walking distance increased by almost 70% in the training group after 7 weeks of training. At baseline, the concentrations of C-reactive protein (CRP) and IL-18 in plasma were increased in subjects with COPD compared with healthy subjects (P<0.05) and leucine rate of appearance (Ra) was ∼15% greater (P<0.05) in subjects with COPD. Training had no effect on the plasma concentration of inflammatory markers but decreased leucine Ra in subjects with COPD by ∼10% (P<0.05). In conclusion, 7 weeks of physical training markedly improved endurance in patients with COPD and accelerated whole-body protein breakdown in patients with COPD was attenuated by physical training independent of changes in inflammatory markers.
AB - Chronic obstructive pulmonary disease (COPD) is associated with increased whole body protein breakdown and low-grade systemic inflammation. We aimed to determine if physical training of patients with COPD induces anti-inflammatory effects and decreases whole-body protein breakdown. Nineteen subjects with severe (FEV1=31±1) COPD were randomized into a training group (n=9) and a control group (n=10). Twenty healthy subjects were studied for baseline comparison. The “COPD training” group participated in an outpatient rehabilitation program consisting of endurance training (walking at 85% of VO2max) twice weekly for 7 weeks plus daily home-based training. Maximum walking distance increased by almost 70% in the training group after 7 weeks of training. At baseline, the concentrations of C-reactive protein (CRP) and IL-18 in plasma were increased in subjects with COPD compared with healthy subjects (P<0.05) and leucine rate of appearance (Ra) was ∼15% greater (P<0.05) in subjects with COPD. Training had no effect on the plasma concentration of inflammatory markers but decreased leucine Ra in subjects with COPD by ∼10% (P<0.05). In conclusion, 7 weeks of physical training markedly improved endurance in patients with COPD and accelerated whole-body protein breakdown in patients with COPD was attenuated by physical training independent of changes in inflammatory markers.
U2 - 10.1111/j.1600-0838.2007.00727.x
DO - 10.1111/j.1600-0838.2007.00727.x
M3 - Journal article
VL - 18
SP - 557
EP - 564
JO - Scandinavian Journal of Medicine & Science in Sports
JF - Scandinavian Journal of Medicine & Science in Sports
SN - 0905-7188
IS - 5
ER -