Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis

Marianne Eijkemans; Monique Mommers; Margreet W. Harskamp-van Ginkel; Tanja G.M. Vrijkotte; Johnny Ludvigsson; Åshild Faresjö; Anna Bergström; Sandra Ekström; Veit Grote; Berthold Koletzko; Klaus Bønnelykke; Anders Ulrik Eliasen; Peter Bager; Mads Melbye; Isabella Annesi-Maesano; Nour Baïz; Henrique Barros; Ana Cristina Santos; Liesbeth Duijts; Sara M. Mensink-Bout; Claudia Flexeder; Sibylle Koletzko; Tamara Schikowski; Merete Åse Eggesbø; Virissa Lenters; Guillermo Fernández-Tardón; Mikel Subiza-Perez; Judith Garcia-Aymerich; Mónica López-Vicente; Jordi Sunyer; Maties Torrent; Ferran Ballester; Cecily Kelleher; John Mehegan; Andrea von Berg; Gunda Herberth; Marie Standl; Claudia E. Kuehni; Eva S.L. Pedersen; Maria Jansen; Ulrike Gehring; Jolanda M.A. Boer; Graham Devereux; Steve Turner; Ville Peltola; Hanna Lagström; Hazel M. Inskip; Katharine C. Pike; Geertje W. Dalmeijer; Cornelis K.van der Ent; Carel Thijs

doi:10.1136/bmjresp-2023-001630

Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis

Marianne Eijkemans, Monique Mommers, Margreet W. Harskamp-van Ginkel, Tanja G.M. Vrijkotte, Johnny Ludvigsson, Åshild Faresjö, Anna Bergström, Sandra Ekström, Veit Grote, Berthold Koletzko, Klaus Bønnelykke, Anders Ulrik Eliasen, Peter Bager, Mads Melbye, Isabella Annesi-Maesano, Nour Baïz, Henrique Barros, Ana Cristina Santos, Liesbeth Duijts, Sara M. Mensink-BoutClaudia Flexeder, Sibylle Koletzko, Tamara Schikowski, Merete Åse Eggesbø, Virissa Lenters, Guillermo Fernández-Tardón, Mikel Subiza-Perez, Judith Garcia-Aymerich, Mónica López-Vicente, Jordi Sunyer, Maties Torrent, Ferran Ballester, Cecily Kelleher, John Mehegan, Andrea von Berg, Gunda Herberth, Marie Standl, Claudia E. Kuehni, Eva S.L. Pedersen, Maria Jansen, Ulrike Gehring, Jolanda M.A. Boer, Graham Devereux, Steve Turner, Ville Peltola, Hanna Lagström, Hazel M. Inskip, Katharine C. Pike, Geertje W. Dalmeijer, Cornelis K.van der Ent, Carel Thijs

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Abstract

OBJECTIVES: To investigate the associations of physical activity (PA) and sedentary behaviour in early childhood with asthma and reduced lung function in later childhood within a large collaborative study. DESIGN: Pooling of longitudinal data from collaborating birth cohorts using meta-analysis of separate cohort-specific estimates and analysis of individual participant data of all cohorts combined. SETTING: Children aged 0-18 years from 26 European birth cohorts. PARTICIPANTS: 136 071 individual children from 26 cohorts, with information on PA and/or sedentary behaviour in early childhood and asthma assessment in later childhood. MAIN OUTCOME MEASURE: Questionnaire-based current asthma and lung function measured by spirometry (forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity) at age 6-18 years. RESULTS: Questionnaire-based and accelerometry-based PA and sedentary behaviour at age 3-5 years was not associated with asthma at age 6-18 years (PA in hours/day adjusted OR 1.01, 95% CI 0.98 to 1.04; sedentary behaviour in hours/day adjusted OR 1.03, 95% CI 0.99 to 1.07). PA was not associated with lung function at any age. Analyses of sedentary behaviour and lung function showed inconsistent results. CONCLUSIONS: Reduced PA and increased sedentary behaviour before 6 years of age were not associated with the presence of asthma later in childhood.

Originalsprog	Engelsk
Tidsskrift	BMJ Open Respiratory Research
Vol/bind	11
Udgave nummer	1
Antal sider	13
ISSN	2052-4439
DOI	https://doi.org/10.1136/bmjresp-2023-001630
Status	Udgivet - 2024

Bibliografisk note

Publisher Copyright:
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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10.1136/bmjresp-2023-001630Licens: CC BY-NC

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Citationsformater

Eijkemans, M., Mommers, M., Harskamp-van Ginkel, M. W., Vrijkotte, T. G. M., Ludvigsson, J., Faresjö, Å., Bergström, A., Ekström, S., Grote, V., Koletzko, B., Bønnelykke, K., Eliasen, A. U., Bager, P., Melbye, M., Annesi-Maesano, I., Baïz, N., Barros, H., Santos, A. C., Duijts, L., ... Thijs, C. (2024). Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis. BMJ Open Respiratory Research, 11(1). https://doi.org/10.1136/bmjresp-2023-001630

Eijkemans, M, Mommers, M, Harskamp-van Ginkel, MW, Vrijkotte, TGM, Ludvigsson, J, Faresjö, Å, Bergström, A, Ekström, S, Grote, V, Koletzko, B, Bønnelykke, K, Eliasen, AU, Bager, P, Melbye, M, Annesi-Maesano, I, Baïz, N, Barros, H, Santos, AC, Duijts, L, Mensink-Bout, SM, Flexeder, C, Koletzko, S, Schikowski, T, Eggesbø, MÅ, Lenters, V, Fernández-Tardón, G, Subiza-Perez, M, Garcia-Aymerich, J, López-Vicente, M, Sunyer, J, Torrent, M, Ballester, F, Kelleher, C, Mehegan, J, Berg, AV, Herberth, G, Standl, M, Kuehni, CE, Pedersen, ESL, Jansen, M, Gehring, U, Boer, JMA, Devereux, G, Turner, S, Peltola, V, Lagström, H, Inskip, HM, Pike, KC, Dalmeijer, GW, Ent, CKVD & Thijs, C 2024, 'Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis', BMJ Open Respiratory Research, bind 11, nr. 1. https://doi.org/10.1136/bmjresp-2023-001630

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title = "Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis",

abstract = "OBJECTIVES: To investigate the associations of physical activity (PA) and sedentary behaviour in early childhood with asthma and reduced lung function in later childhood within a large collaborative study. DESIGN: Pooling of longitudinal data from collaborating birth cohorts using meta-analysis of separate cohort-specific estimates and analysis of individual participant data of all cohorts combined. SETTING: Children aged 0-18 years from 26 European birth cohorts. PARTICIPANTS: 136 071 individual children from 26 cohorts, with information on PA and/or sedentary behaviour in early childhood and asthma assessment in later childhood. MAIN OUTCOME MEASURE: Questionnaire-based current asthma and lung function measured by spirometry (forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity) at age 6-18 years. RESULTS: Questionnaire-based and accelerometry-based PA and sedentary behaviour at age 3-5 years was not associated with asthma at age 6-18 years (PA in hours/day adjusted OR 1.01, 95% CI 0.98 to 1.04; sedentary behaviour in hours/day adjusted OR 1.03, 95% CI 0.99 to 1.07). PA was not associated with lung function at any age. Analyses of sedentary behaviour and lung function showed inconsistent results. CONCLUSIONS: Reduced PA and increased sedentary behaviour before 6 years of age were not associated with the presence of asthma later in childhood.",

keywords = "Asthma, Exercise, Paediatric asthma",

author = "Marianne Eijkemans and Monique Mommers and {Harskamp-van Ginkel}, {Margreet W.} and Vrijkotte, {Tanja G.M.} and Johnny Ludvigsson and {\AA}shild Faresj{\"o} and Anna Bergstr{\"o}m and Sandra Ekstr{\"o}m and Veit Grote and Berthold Koletzko and Klaus B{\o}nnelykke and Eliasen, {Anders Ulrik} and Peter Bager and Mads Melbye and Isabella Annesi-Maesano and Nour Ba{\"i}z and Henrique Barros and Santos, {Ana Cristina} and Liesbeth Duijts and Mensink-Bout, {Sara M.} and Claudia Flexeder and Sibylle Koletzko and Tamara Schikowski and Eggesb{\o}, {Merete {\AA}se} and Virissa Lenters and Guillermo Fern{\'a}ndez-Tard{\'o}n and Mikel Subiza-Perez and Judith Garcia-Aymerich and M{\'o}nica L{\'o}pez-Vicente and Jordi Sunyer and Maties Torrent and Ferran Ballester and Cecily Kelleher and John Mehegan and Berg, {Andrea von} and Gunda Herberth and Marie Standl and Kuehni, {Claudia E.} and Pedersen, {Eva S.L.} and Maria Jansen and Ulrike Gehring and Boer, {Jolanda M.A.} and Graham Devereux and Steve Turner and Ville Peltola and Hanna Lagstr{\"o}m and Inskip, {Hazel M.} and Pike, {Katharine C.} and Dalmeijer, {Geertje W.} and Ent, {Cornelis K.van der} and Carel Thijs",

note = "Publisher Copyright: {\textcopyright} Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",

year = "2024",

doi = "10.1136/bmjresp-2023-001630",

language = "English",

volume = "11",

journal = "BMJ Open Respiratory Research",

issn = "2052-4439",

publisher = "B M J Group",

number = "1",

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TY - JOUR

T1 - Physical activity, sedentary behaviour, and childhood asthma

T2 - a European collaborative analysis

AU - Eijkemans, Marianne

AU - Mommers, Monique

AU - Harskamp-van Ginkel, Margreet W.

AU - Vrijkotte, Tanja G.M.

AU - Ludvigsson, Johnny

AU - Faresjö, Åshild

AU - Bergström, Anna

AU - Ekström, Sandra

AU - Grote, Veit

AU - Koletzko, Berthold

AU - Bønnelykke, Klaus

AU - Eliasen, Anders Ulrik

AU - Bager, Peter

AU - Melbye, Mads

AU - Annesi-Maesano, Isabella

AU - Baïz, Nour

AU - Barros, Henrique

AU - Santos, Ana Cristina

AU - Duijts, Liesbeth

AU - Mensink-Bout, Sara M.

AU - Flexeder, Claudia

AU - Koletzko, Sibylle

AU - Schikowski, Tamara

AU - Eggesbø, Merete Åse

AU - Lenters, Virissa

AU - Fernández-Tardón, Guillermo

AU - Subiza-Perez, Mikel

AU - Garcia-Aymerich, Judith

AU - López-Vicente, Mónica

AU - Sunyer, Jordi

AU - Torrent, Maties

AU - Ballester, Ferran

AU - Kelleher, Cecily

AU - Mehegan, John

AU - Berg, Andrea von

AU - Herberth, Gunda

AU - Standl, Marie

AU - Kuehni, Claudia E.

AU - Pedersen, Eva S.L.

AU - Jansen, Maria

AU - Gehring, Ulrike

AU - Boer, Jolanda M.A.

AU - Devereux, Graham

AU - Turner, Steve

AU - Peltola, Ville

AU - Lagström, Hanna

AU - Inskip, Hazel M.

AU - Pike, Katharine C.

AU - Dalmeijer, Geertje W.

AU - Ent, Cornelis K.van der

AU - Thijs, Carel

PY - 2024

Y1 - 2024

N2 - OBJECTIVES: To investigate the associations of physical activity (PA) and sedentary behaviour in early childhood with asthma and reduced lung function in later childhood within a large collaborative study. DESIGN: Pooling of longitudinal data from collaborating birth cohorts using meta-analysis of separate cohort-specific estimates and analysis of individual participant data of all cohorts combined. SETTING: Children aged 0-18 years from 26 European birth cohorts. PARTICIPANTS: 136 071 individual children from 26 cohorts, with information on PA and/or sedentary behaviour in early childhood and asthma assessment in later childhood. MAIN OUTCOME MEASURE: Questionnaire-based current asthma and lung function measured by spirometry (forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity) at age 6-18 years. RESULTS: Questionnaire-based and accelerometry-based PA and sedentary behaviour at age 3-5 years was not associated with asthma at age 6-18 years (PA in hours/day adjusted OR 1.01, 95% CI 0.98 to 1.04; sedentary behaviour in hours/day adjusted OR 1.03, 95% CI 0.99 to 1.07). PA was not associated with lung function at any age. Analyses of sedentary behaviour and lung function showed inconsistent results. CONCLUSIONS: Reduced PA and increased sedentary behaviour before 6 years of age were not associated with the presence of asthma later in childhood.

AB - OBJECTIVES: To investigate the associations of physical activity (PA) and sedentary behaviour in early childhood with asthma and reduced lung function in later childhood within a large collaborative study. DESIGN: Pooling of longitudinal data from collaborating birth cohorts using meta-analysis of separate cohort-specific estimates and analysis of individual participant data of all cohorts combined. SETTING: Children aged 0-18 years from 26 European birth cohorts. PARTICIPANTS: 136 071 individual children from 26 cohorts, with information on PA and/or sedentary behaviour in early childhood and asthma assessment in later childhood. MAIN OUTCOME MEASURE: Questionnaire-based current asthma and lung function measured by spirometry (forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity) at age 6-18 years. RESULTS: Questionnaire-based and accelerometry-based PA and sedentary behaviour at age 3-5 years was not associated with asthma at age 6-18 years (PA in hours/day adjusted OR 1.01, 95% CI 0.98 to 1.04; sedentary behaviour in hours/day adjusted OR 1.03, 95% CI 0.99 to 1.07). PA was not associated with lung function at any age. Analyses of sedentary behaviour and lung function showed inconsistent results. CONCLUSIONS: Reduced PA and increased sedentary behaviour before 6 years of age were not associated with the presence of asthma later in childhood.

KW - Asthma

KW - Exercise

KW - Paediatric asthma

U2 - 10.1136/bmjresp-2023-001630

DO - 10.1136/bmjresp-2023-001630

M3 - Journal article

C2 - 39147399

AN - SCOPUS:85201519073

SN - 2052-4439

VL - 11

JO - BMJ Open Respiratory Research

JF - BMJ Open Respiratory Research

IS - 1

ER -