Physical fitness in community-dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures

Josué L. Castro-Mejia, Bekzod Khakimov, Lukasz Krych, Jacob Bülow, Rasmus L. Bechshøft, Grith Højfeldt, Kenneth H. Mertz, Eva Stahl Garne, Simon R. Schacht, Hajar F. Ahmad, Witold Kot, Lars H. Hansen, Federico J. A. Perez-Cueto, Mads V. Lind, Aske J. Lassen, Inge Tetens, Tenna Jensen, Søren Reitelseder, Astrid P. Jespersen, Lars HolmSøren B. Engelsen, Dennis S. Nielsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

43 Citationer (Scopus)
127 Downloads (Pure)

Abstract

When humans age, changes in body composition arise along with lifestyle-associated disorders influencing fitness and physical decline. Here we provide a comprehensive view of dietary intake, physical activity, gut microbiota (GM), and host metabolome in relation to physical fitness of 207 community-dwelling subjects aged +65 years. Stratification on anthropometric/body composition/physical performance measurements (ABPm) variables identified two phenotypes (high/low-fitness) clearly linked to dietary intake, physical activity, GM, and host metabolome patterns. Strikingly, despite a higher energy intake high-fitness subjects were characterized by leaner bodies and lower fasting proinsulin-C-peptide/blood glucose levels in a mechanism likely driven by higher dietary fiber intake, physical activity and increased abundance of Bifidobacteriales and Clostridiales species in GM and associated metabolites (i.e., enterolactone). These factors explained 50.1% of the individual variation in physical fitness. We propose that targeting dietary strategies for modulation of GM and host metabolome interactions may allow establishing therapeutic approaches to delay and possibly revert comorbidities of aging.
OriginalsprogEngelsk
Artikelnummere13105
TidsskriftAging Cell
Vol/bind19
Udgave nummer3
Antal sider13
ISSN1474-9718
DOI
StatusUdgivet - 2020

Bibliografisk note

CURIS 2020 NEXS 034

Citationsformater