Physiology of cell volume regulation in vertebrates

Else K Hoffmann; Ian H Lambert; Stine F Pedersen

doi:10.1152/physrev.00037.2007

Physiology of cell volume regulation in vertebrates

Else K Hoffmann, Ian H Lambert, Stine F Pedersen

Cellebiologi og Fysiologi

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

1254 Citationer (Scopus)

Abstract

Udgivelsesdato: 2009-Jan

Originalsprog	Engelsk
Tidsskrift	Physiological Reviews
Vol/bind	89
Udgave nummer	1
Sider (fra-til)	193-277
Antal sider	84
ISSN	0031-9333
DOI	https://doi.org/10.1152/physrev.00037.2007
Status	Udgivet - 2009

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10.1152/physrev.00037.2007

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Citationsformater

@article{0d3a0660e08d11ddb5fc000ea68e967b,

title = "Physiology of cell volume regulation in vertebrates",

abstract = "The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a wide array of signaling events, leading to protective (e.g., cytoskeletal rearrangement) and adaptive (e.g., altered expression of osmolyte transporters and heat shock proteins) measures and, in most cases, activation of volume regulatory osmolyte transport. After acute swelling, cell volume is regulated by the process of regulatory volume decrease (RVD), which involves the activation of KCl cotransport and of channels mediating K(+), Cl(-), and taurine efflux. Conversely, after acute shrinkage, cell volume is regulated by the process of regulatory volume increase (RVI), which is mediated primarily by Na(+)/H(+) exchange, Na(+)-K(+)-2Cl(-) cotransport, and Na(+) channels. Here, we review in detail the current knowledge regarding the molecular identity of these transport pathways and their regulation by, e.g., membrane deformation, ionic strength, Ca(2+), protein kinases and phosphatases, cytoskeletal elements, GTP binding proteins, lipid mediators, and reactive oxygen species, upon changes in cell volume. We also discuss the nature of the upstream elements in volume sensing in vertebrate organisms. Importantly, cell volume impacts on a wide array of physiological processes, including transepithelial transport; cell migration, proliferation, and death; and changes in cell volume function as specific signals regulating these processes. A discussion of this issue concludes the review.",

author = "Hoffmann, {Else K} and Lambert, {Ian H} and Pedersen, {Stine F}",

year = "2009",

doi = "10.1152/physrev.00037.2007",

language = "English",

volume = "89",

pages = "193--277",

journal = "Physiological Reviews",

issn = "0031-9333",

publisher = "American Physiological Society",

number = "1",

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TY - JOUR

T1 - Physiology of cell volume regulation in vertebrates

AU - Hoffmann, Else K

AU - Lambert, Ian H

AU - Pedersen, Stine F

PY - 2009

Y1 - 2009

N2 - The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a wide array of signaling events, leading to protective (e.g., cytoskeletal rearrangement) and adaptive (e.g., altered expression of osmolyte transporters and heat shock proteins) measures and, in most cases, activation of volume regulatory osmolyte transport. After acute swelling, cell volume is regulated by the process of regulatory volume decrease (RVD), which involves the activation of KCl cotransport and of channels mediating K(+), Cl(-), and taurine efflux. Conversely, after acute shrinkage, cell volume is regulated by the process of regulatory volume increase (RVI), which is mediated primarily by Na(+)/H(+) exchange, Na(+)-K(+)-2Cl(-) cotransport, and Na(+) channels. Here, we review in detail the current knowledge regarding the molecular identity of these transport pathways and their regulation by, e.g., membrane deformation, ionic strength, Ca(2+), protein kinases and phosphatases, cytoskeletal elements, GTP binding proteins, lipid mediators, and reactive oxygen species, upon changes in cell volume. We also discuss the nature of the upstream elements in volume sensing in vertebrate organisms. Importantly, cell volume impacts on a wide array of physiological processes, including transepithelial transport; cell migration, proliferation, and death; and changes in cell volume function as specific signals regulating these processes. A discussion of this issue concludes the review.

AB - The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a wide array of signaling events, leading to protective (e.g., cytoskeletal rearrangement) and adaptive (e.g., altered expression of osmolyte transporters and heat shock proteins) measures and, in most cases, activation of volume regulatory osmolyte transport. After acute swelling, cell volume is regulated by the process of regulatory volume decrease (RVD), which involves the activation of KCl cotransport and of channels mediating K(+), Cl(-), and taurine efflux. Conversely, after acute shrinkage, cell volume is regulated by the process of regulatory volume increase (RVI), which is mediated primarily by Na(+)/H(+) exchange, Na(+)-K(+)-2Cl(-) cotransport, and Na(+) channels. Here, we review in detail the current knowledge regarding the molecular identity of these transport pathways and their regulation by, e.g., membrane deformation, ionic strength, Ca(2+), protein kinases and phosphatases, cytoskeletal elements, GTP binding proteins, lipid mediators, and reactive oxygen species, upon changes in cell volume. We also discuss the nature of the upstream elements in volume sensing in vertebrate organisms. Importantly, cell volume impacts on a wide array of physiological processes, including transepithelial transport; cell migration, proliferation, and death; and changes in cell volume function as specific signals regulating these processes. A discussion of this issue concludes the review.

U2 - 10.1152/physrev.00037.2007

DO - 10.1152/physrev.00037.2007

M3 - Journal article

C2 - 19126758

SN - 0031-9333

VL - 89

SP - 193

EP - 277

JO - Physiological Reviews

JF - Physiological Reviews

IS - 1

ER -