TY - JOUR
T1 - Plasma adiponectin before and after kidney transplantation
AU - Idorn, Thomas
AU - Hornum, Mads
AU - Bjerre, Mette
AU - Jørgensen, Kaj Anker
AU - Nielsen, Finn Thomsen
AU - Hansen, Jesper Melchior
AU - Flyvbjerg, Allan
AU - Feldt-Rasmussen, Bo
N1 - © 2012 The Authors. Transplant International © 2012 European Society for Organ Transplantation.
PY - 2012
Y1 - 2012
N2 - The role of plasma adiponectin (ADPN) in patients with impaired kidney function and following kidney transplantation (Tx) is debated. We aimed to: (i) determine whether pretransplant ADPN level is an independent risk factor for deterioration of glucose tolerance including development of new-onset diabetes mellitus after Tx, (ii) describe which parameters that influence the ADPN concentration before and after Tx. Fifty-seven nondiabetic kidney allograft recipients and 40 nondiabetic uraemic patients were included. The Tx group was examined at baseline and 3 and 12 months after Tx. The uraemic control group was examined twice, separated by 12 months. ADPN levels declined significantly following Tx (P <0.0001), while estimated glomerular filtration rate (eGFR) increased (P <0.0005). eGFR, BMI and insulin sensitivity index were independently associated with ADPN in a multivariate regression analysis, whereas an ordinal logistic regression analysis revealed no predictive characteristic of ADPN for aggravation of the glucose tolerance after Tx. In conclusion, kidney transplantation is accompanied by a significant reduction in ADPN concentration. Several factors determine the ADPN concentration before and after Tx including kidney function, insulin resistance, use of immunosuppressive agents and BMI. Pretransplant ADPN level did not predict development of new-onset diabetes mellitus or even deterioration of the glucose tolerance following Tx.
AB - The role of plasma adiponectin (ADPN) in patients with impaired kidney function and following kidney transplantation (Tx) is debated. We aimed to: (i) determine whether pretransplant ADPN level is an independent risk factor for deterioration of glucose tolerance including development of new-onset diabetes mellitus after Tx, (ii) describe which parameters that influence the ADPN concentration before and after Tx. Fifty-seven nondiabetic kidney allograft recipients and 40 nondiabetic uraemic patients were included. The Tx group was examined at baseline and 3 and 12 months after Tx. The uraemic control group was examined twice, separated by 12 months. ADPN levels declined significantly following Tx (P <0.0001), while estimated glomerular filtration rate (eGFR) increased (P <0.0005). eGFR, BMI and insulin sensitivity index were independently associated with ADPN in a multivariate regression analysis, whereas an ordinal logistic regression analysis revealed no predictive characteristic of ADPN for aggravation of the glucose tolerance after Tx. In conclusion, kidney transplantation is accompanied by a significant reduction in ADPN concentration. Several factors determine the ADPN concentration before and after Tx including kidney function, insulin resistance, use of immunosuppressive agents and BMI. Pretransplant ADPN level did not predict development of new-onset diabetes mellitus or even deterioration of the glucose tolerance following Tx.
U2 - http://dx.doi.org/10.1111/j.1432-2277.2012.01560.x
DO - http://dx.doi.org/10.1111/j.1432-2277.2012.01560.x
M3 - Journal article
VL - 25
SP - 1194
EP - 1203
JO - Transplant International
JF - Transplant International
SN - 0934-0874
IS - 11
ER -