Plasma Concentration of 36 (Poly)phenols and Prospective Body Weight Change in Participants from the EPIC Cohort

Mercedes Gil-Lespinard; Enrique Almanza-Aguilera; Jazmín Castañeda; Daniel Guiñón-Fort; Anne Kirstine Eriksen; Anne Tjønneland; Joseph A. Rothwell; Sanam Shah; Claire Cadeau; Verena Katzke; Theron Johnson; Matthias B. Schulze; Andreina Oliverio; Fabrizio Pasanisi; Rosario Tumino; Luca Manfredi; Giovana Masala; Guri Skeie; Marie Wasmuth Lundblad; Magritt Brustad; Cristina Lasheras; Marta Crous-Bou; Esther Molina-Montes; Sandra Colorado-Yohar; Marcela Guevara; Pilar Amiano; Ingegerd Johansson; Johan Hultdin; Nita G. Forouhi; Heinz Freisling; Mira Merdas; Charlotte Debras; Alicia K. Heath; Elom K. Aglago; Dagfinn Aune; Raul Zamora-Ros

doi:10.1159/000535803

Plasma Concentration of 36 (Poly)phenols and Prospective Body Weight Change in Participants from the EPIC Cohort

Mercedes Gil-Lespinard, Enrique Almanza-Aguilera, Jazmín Castañeda, Daniel Guiñón-Fort, Anne Kirstine Eriksen, Anne Tjønneland, Joseph A. Rothwell, Sanam Shah, Claire Cadeau, Verena Katzke, Theron Johnson, Matthias B. Schulze, Andreina Oliverio, Fabrizio Pasanisi, Rosario Tumino, Luca Manfredi, Giovana Masala, Guri Skeie, Marie Wasmuth Lundblad, Magritt BrustadCristina Lasheras, Marta Crous-Bou, Esther Molina-Montes, Sandra Colorado-Yohar, Marcela Guevara, Pilar Amiano, Ingegerd Johansson, Johan Hultdin, Nita G. Forouhi, Heinz Freisling, Mira Merdas, Charlotte Debras, Alicia K. Heath, Elom K. Aglago, Dagfinn Aune, Raul Zamora-Ros^*

^*Corresponding author af dette arbejde

Afdeling for Miljø og Sundhed

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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Abstract

Introduction: Dietary intake of (poly)phenols has been linked to reduced adiposity and body weight (BW) in several epidemiological studies. However, epidemiological evidence on (poly)phenol biomarkers, particularly plasma concentrations, is scarce. We aimed to investigate the associations between plasma (poly)phenols and prospective BW change in participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: This study included 761 participants with data on BW at baseline and after 5 years of follow-up. Plasma concentrations of 36 (poly)phenols were measured at baseline using liquid chromatography-tandem mass spectrometry. Associations were assessed through general linear mixed models and multinomial logistic regression models, using change in BW as a continuous or as a categorical variable (BW loss, maintenance, gain), respectively. Plasma (poly)phenols were assessed as log2-transformed continuous variables. The false discovery rate (FDR) was used to control for multiple comparisons. Results: Doubling plasma (poly)phenol concentrations showed a borderline trend towards a positive association with BW loss. Plasma vanillic acid showed the strongest association (−0.53 kg/5 years; 95% confidence interval [CI]: −0.99, −0.07). Similar results were observed for plasma naringenin comparing BW loss versus BW maintenance (odds ratio: 1.1; 95% CI: 1.0, 1.2). These results did not remain significant after FDR correction. Conclusion: Higher concentrations of plasma (poly)phenols suggested a tendency towards 5-year BW maintenance or loss. While certain associations seemed promising, they did not withstand FDR correction, indicating the need for caution in interpreting these results. Further studies using (poly)phenol biomarkers are needed to confirm these suggestive protective trends.

Journal Section:Human Nutrition: Research Article
Keywords:Plasma (poly)phenol, Body weight, Nutritional biomarker, Cohort, EPIC

Originalsprog	Engelsk
Tidsskrift	Annals of Nutrition and Metabolism
Vol/bind	80
Udgave nummer	2
Sider (fra-til)	87-100
Antal sider	14
ISSN	0250-6807
DOI	https://doi.org/10.1159/000535803
Status	Udgivet - 2024

Bibliografisk note

Publisher Copyright:
© 2024 The Author(s). Published by S. Karger AG, Basel.

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10.1159/000535803Licens: CC BY

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Gil-Lespinard, M., Almanza-Aguilera, E., Castañeda, J., Guiñón-Fort, D., Eriksen, A. K., Tjønneland, A., Rothwell, J. A., Shah, S., Cadeau, C., Katzke, V., Johnson, T., Schulze, M. B., Oliverio, A., Pasanisi, F., Tumino, R., Manfredi, L., Masala, G., Skeie, G., Lundblad, M. W., ... Zamora-Ros, R. (2024). Plasma Concentration of 36 (Poly)phenols and Prospective Body Weight Change in Participants from the EPIC Cohort. Annals of Nutrition and Metabolism, 80(2), 87-100. https://doi.org/10.1159/000535803

Plasma Concentration of 36 (Poly)phenols and Prospective Body Weight Change in Participants from the EPIC Cohort. / Gil-Lespinard, Mercedes; Almanza-Aguilera, Enrique; Castañeda, Jazmín; Guiñón-Fort, Daniel; Eriksen, Anne Kirstine; Tjønneland, Anne; Rothwell, Joseph A.; Shah, Sanam; Cadeau, Claire; Katzke, Verena; Johnson, Theron; Schulze, Matthias B.; Oliverio, Andreina; Pasanisi, Fabrizio; Tumino, Rosario; Manfredi, Luca; Masala, Giovana; Skeie, Guri; Lundblad, Marie Wasmuth; Brustad, Magritt; Lasheras, Cristina; Crous-Bou, Marta; Molina-Montes, Esther; Colorado-Yohar, Sandra; Guevara, Marcela; Amiano, Pilar; Johansson, Ingegerd; Hultdin, Johan; Forouhi, Nita G.; Freisling, Heinz; Merdas, Mira; Debras, Charlotte; Heath, Alicia K.; Aglago, Elom K.; Aune, Dagfinn; Zamora-Ros, Raul.

I: Annals of Nutrition and Metabolism, Bind 80, Nr. 2, 2024, s. 87-100.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Gil-Lespinard, M, Almanza-Aguilera, E, Castañeda, J, Guiñón-Fort, D, Eriksen, AK, Tjønneland, A, Rothwell, JA, Shah, S, Cadeau, C, Katzke, V, Johnson, T, Schulze, MB, Oliverio, A, Pasanisi, F, Tumino, R, Manfredi, L, Masala, G, Skeie, G, Lundblad, MW, Brustad, M, Lasheras, C, Crous-Bou, M, Molina-Montes, E, Colorado-Yohar, S, Guevara, M, Amiano, P, Johansson, I, Hultdin, J, Forouhi, NG, Freisling, H, Merdas, M, Debras, C, Heath, AK, Aglago, EK, Aune, D & Zamora-Ros, R 2024, 'Plasma Concentration of 36 (Poly)phenols and Prospective Body Weight Change in Participants from the EPIC Cohort', Annals of Nutrition and Metabolism, bind 80, nr. 2, s. 87-100. https://doi.org/10.1159/000535803

Gil-Lespinard, Mercedes ; Almanza-Aguilera, Enrique ; Castañeda, Jazmín ; Guiñón-Fort, Daniel ; Eriksen, Anne Kirstine ; Tjønneland, Anne ; Rothwell, Joseph A. ; Shah, Sanam ; Cadeau, Claire ; Katzke, Verena ; Johnson, Theron ; Schulze, Matthias B. ; Oliverio, Andreina ; Pasanisi, Fabrizio ; Tumino, Rosario ; Manfredi, Luca ; Masala, Giovana ; Skeie, Guri ; Lundblad, Marie Wasmuth ; Brustad, Magritt ; Lasheras, Cristina ; Crous-Bou, Marta ; Molina-Montes, Esther ; Colorado-Yohar, Sandra ; Guevara, Marcela ; Amiano, Pilar ; Johansson, Ingegerd ; Hultdin, Johan ; Forouhi, Nita G. ; Freisling, Heinz ; Merdas, Mira ; Debras, Charlotte ; Heath, Alicia K. ; Aglago, Elom K. ; Aune, Dagfinn ; Zamora-Ros, Raul. / Plasma Concentration of 36 (Poly)phenols and Prospective Body Weight Change in Participants from the EPIC Cohort. I: Annals of Nutrition and Metabolism. 2024 ; Bind 80, Nr. 2. s. 87-100.

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title = "Plasma Concentration of 36 (Poly)phenols and Prospective Body Weight Change in Participants from the EPIC Cohort",

abstract = "Introduction: Dietary intake of (poly)phenols has been linked to reduced adiposity and body weight (BW) in several epidemiological studies. However, epidemiological evidence on (poly)phenol biomarkers, particularly plasma concentrations, is scarce. We aimed to investigate the associations between plasma (poly)phenols and prospective BW change in participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: This study included 761 participants with data on BW at baseline and after 5 years of follow-up. Plasma concentrations of 36 (poly)phenols were measured at baseline using liquid chromatography-tandem mass spectrometry. Associations were assessed through general linear mixed models and multinomial logistic regression models, using change in BW as a continuous or as a categorical variable (BW loss, maintenance, gain), respectively. Plasma (poly)phenols were assessed as log2-transformed continuous variables. The false discovery rate (FDR) was used to control for multiple comparisons. Results: Doubling plasma (poly)phenol concentrations showed a borderline trend towards a positive association with BW loss. Plasma vanillic acid showed the strongest association (−0.53 kg/5 years; 95% confidence interval [CI]: −0.99, −0.07). Similar results were observed for plasma naringenin comparing BW loss versus BW maintenance (odds ratio: 1.1; 95% CI: 1.0, 1.2). These results did not remain significant after FDR correction. Conclusion: Higher concentrations of plasma (poly)phenols suggested a tendency towards 5-year BW maintenance or loss. While certain associations seemed promising, they did not withstand FDR correction, indicating the need for caution in interpreting these results. Further studies using (poly) phenol biomarkers are needed to confirm these suggestive protective trends.",

keywords = "Body weight, Cohort, EPIC, Nutritional biomarker, Plasma (poly)phenol",

author = "Mercedes Gil-Lespinard and Enrique Almanza-Aguilera and Jazm{\'i}n Casta{\~n}eda and Daniel Gui{\~n}{\'o}n-Fort and Eriksen, {Anne Kirstine} and Anne Tj{\o}nneland and Rothwell, {Joseph A.} and Sanam Shah and Claire Cadeau and Verena Katzke and Theron Johnson and Schulze, {Matthias B.} and Andreina Oliverio and Fabrizio Pasanisi and Rosario Tumino and Luca Manfredi and Giovana Masala and Guri Skeie and Lundblad, {Marie Wasmuth} and Magritt Brustad and Cristina Lasheras and Marta Crous-Bou and Esther Molina-Montes and Sandra Colorado-Yohar and Marcela Guevara and Pilar Amiano and Ingegerd Johansson and Johan Hultdin and Forouhi, {Nita G.} and Heinz Freisling and Mira Merdas and Charlotte Debras and Heath, {Alicia K.} and Aglago, {Elom K.} and Dagfinn Aune and Raul Zamora-Ros",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). Published by S. Karger AG, Basel.",

year = "2024",

doi = "10.1159/000535803",

language = "English",

volume = "80",

pages = "87--100",

journal = "Annals of Nutrition and Metabolism",

issn = "0250-6807",

publisher = "S Karger AG",

number = "2",

}

TY - JOUR

T1 - Plasma Concentration of 36 (Poly)phenols and Prospective Body Weight Change in Participants from the EPIC Cohort

AU - Gil-Lespinard, Mercedes

AU - Almanza-Aguilera, Enrique

AU - Castañeda, Jazmín

AU - Guiñón-Fort, Daniel

AU - Eriksen, Anne Kirstine

AU - Tjønneland, Anne

AU - Rothwell, Joseph A.

AU - Shah, Sanam

AU - Cadeau, Claire

AU - Katzke, Verena

AU - Johnson, Theron

AU - Schulze, Matthias B.

AU - Oliverio, Andreina

AU - Pasanisi, Fabrizio

AU - Tumino, Rosario

AU - Manfredi, Luca

AU - Masala, Giovana

AU - Skeie, Guri

AU - Lundblad, Marie Wasmuth

AU - Brustad, Magritt

AU - Lasheras, Cristina

AU - Crous-Bou, Marta

AU - Molina-Montes, Esther

AU - Colorado-Yohar, Sandra

AU - Guevara, Marcela

AU - Amiano, Pilar

AU - Johansson, Ingegerd

AU - Hultdin, Johan

AU - Forouhi, Nita G.

AU - Freisling, Heinz

AU - Merdas, Mira

AU - Debras, Charlotte

AU - Heath, Alicia K.

AU - Aglago, Elom K.

AU - Aune, Dagfinn

AU - Zamora-Ros, Raul

PY - 2024

Y1 - 2024

N2 - Introduction: Dietary intake of (poly)phenols has been linked to reduced adiposity and body weight (BW) in several epidemiological studies. However, epidemiological evidence on (poly)phenol biomarkers, particularly plasma concentrations, is scarce. We aimed to investigate the associations between plasma (poly)phenols and prospective BW change in participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: This study included 761 participants with data on BW at baseline and after 5 years of follow-up. Plasma concentrations of 36 (poly)phenols were measured at baseline using liquid chromatography-tandem mass spectrometry. Associations were assessed through general linear mixed models and multinomial logistic regression models, using change in BW as a continuous or as a categorical variable (BW loss, maintenance, gain), respectively. Plasma (poly)phenols were assessed as log2-transformed continuous variables. The false discovery rate (FDR) was used to control for multiple comparisons. Results: Doubling plasma (poly)phenol concentrations showed a borderline trend towards a positive association with BW loss. Plasma vanillic acid showed the strongest association (−0.53 kg/5 years; 95% confidence interval [CI]: −0.99, −0.07). Similar results were observed for plasma naringenin comparing BW loss versus BW maintenance (odds ratio: 1.1; 95% CI: 1.0, 1.2). These results did not remain significant after FDR correction. Conclusion: Higher concentrations of plasma (poly)phenols suggested a tendency towards 5-year BW maintenance or loss. While certain associations seemed promising, they did not withstand FDR correction, indicating the need for caution in interpreting these results. Further studies using (poly) phenol biomarkers are needed to confirm these suggestive protective trends.

AB - Introduction: Dietary intake of (poly)phenols has been linked to reduced adiposity and body weight (BW) in several epidemiological studies. However, epidemiological evidence on (poly)phenol biomarkers, particularly plasma concentrations, is scarce. We aimed to investigate the associations between plasma (poly)phenols and prospective BW change in participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: This study included 761 participants with data on BW at baseline and after 5 years of follow-up. Plasma concentrations of 36 (poly)phenols were measured at baseline using liquid chromatography-tandem mass spectrometry. Associations were assessed through general linear mixed models and multinomial logistic regression models, using change in BW as a continuous or as a categorical variable (BW loss, maintenance, gain), respectively. Plasma (poly)phenols were assessed as log2-transformed continuous variables. The false discovery rate (FDR) was used to control for multiple comparisons. Results: Doubling plasma (poly)phenol concentrations showed a borderline trend towards a positive association with BW loss. Plasma vanillic acid showed the strongest association (−0.53 kg/5 years; 95% confidence interval [CI]: −0.99, −0.07). Similar results were observed for plasma naringenin comparing BW loss versus BW maintenance (odds ratio: 1.1; 95% CI: 1.0, 1.2). These results did not remain significant after FDR correction. Conclusion: Higher concentrations of plasma (poly)phenols suggested a tendency towards 5-year BW maintenance or loss. While certain associations seemed promising, they did not withstand FDR correction, indicating the need for caution in interpreting these results. Further studies using (poly) phenol biomarkers are needed to confirm these suggestive protective trends.

KW - Body weight

KW - Cohort

KW - EPIC

KW - Nutritional biomarker

KW - Plasma (poly)phenol

U2 - 10.1159/000535803

DO - 10.1159/000535803

M3 - Journal article

C2 - 38272006

AN - SCOPUS:85189860401

VL - 80

SP - 87

EP - 100

JO - Annals of Nutrition and Metabolism

JF - Annals of Nutrition and Metabolism

SN - 0250-6807

IS - 2

ER -