Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

Benjamin F Voight; Gina M Peloso; Marju Orho-Melander; Ruth Frikke-Schmidt; Maja Barbalic; Majken Karoline Jensen; George Hindy; Hilma Hólm; Eric L Ding; Toby Johnson; Heribert Schunkert; Nilesh J Samani; Robert Clarke; Jemma C Hopewell; John F Thompson; Mingyao Li; Gudmar Thorleifsson; Christopher Newton-Cheh; Kiran Musunuru; James P Pirruccello; Danish Saleheen; Li Chen; Alexandre F R Stewart; Arne Schillert; Unnur Thorsteinsdottir; Gudmundur Thorgeirsson; Sonia Anand; James C Engert; Thomas Morgan; John Spertus; Monika Stoll; Klaus Berger; Nicola Martinelli; Domenico Girelli; Pascal P McKeown; Christopher C Patterson; Stephen E Epstein; Joseph Devaney; Mary-Susan Burnett; Vincent Mooser; Samuli Ripatti; Ida Surakka; Markku S Nieminen; Juha Sinisalo; Marja-Liisa Lokki; Markus Perola; Aki Havulinna; Ulf de Faire; Bruna Gigante; Erik Ingelsson; Tanja Zeller; Philipp Wild; Paul I W de Bakker; Olaf H Klungel; Anke-Hilse Maitland-van der Zee; Bas J M Peters; Anthonius de Boer; Diederick E Grobbee; Pieter W Kamphuisen; Vera H M Deneer; Clara C Elbers; N Charlotte Onland-Moret; Marten H Hofker; Cisca Wijmenga; W M Monique Verschuren; Jolanda M A Boer; Yvonne T van der Schouw; Asif Rasheed; Philippe Frossard; Serkalem Demissie; Cristen Willer; Ron Do; Jose M Ordovas; Gonçalo R Abecasis; Michael Boehnke; Karen L Mohlke; Mark J Daly; Candace Guiducci; Noël P Burtt; Aarti Surti; Elena Gonzalez; Shaun Purcell; Stacey Gabriel; Jaume Marrugat; John Peden; Jeanette Erdmann; Patrick Diemert; Christina Willenborg; Inke R König; Marcus Fischer; Christian Hengstenberg; Andreas Ziegler; Ian Buysschaert; Diether Lambrechts; Frans Van de Werf; Keith A Fox; Nour Eddine El Mokhtari; Diana Rubin; Jürgen Schrezenmeir; Stefan Schreiber; Arne Schäfer; John Danesh; Stefan Blankenberg; Robert Roberts; Ruth McPherson; Hugh Watkins; Alistair S Hall; Kim Overvad; Eric Rimm; Eric Boerwinkle; Anne Tybjaerg-Hansen; L Adrienne Cupples; Muredach P Reilly; Olle Melander; Pier M Mannucci; Diego Ardissino; David Siscovick; Roberto Elosua; Kari Stefansson; Christopher J O'Donnell; Veikko Salomaa; Daniel J Rader; Leena Peltonen; Stephen M Schwartz; David Altshuler; Sekar Kathiresan

doi:10.1016/S0140-6736(12)60312-2

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

Benjamin F Voight, Gina M Peloso, Marju Orho-Melander, Ruth Frikke-Schmidt, Maja Barbalic, Majken Karoline Jensen, George Hindy, Hilma Hólm, Eric L Ding, Toby Johnson, Heribert Schunkert, Nilesh J Samani, Robert Clarke, Jemma C Hopewell, John F Thompson, Mingyao Li, Gudmar Thorleifsson, Christopher Newton-Cheh, Kiran Musunuru, James P PirruccelloDanish Saleheen, Li Chen, Alexandre F R Stewart, Arne Schillert, Unnur Thorsteinsdottir, Gudmundur Thorgeirsson, Sonia Anand, James C Engert, Thomas Morgan, John Spertus, Monika Stoll, Klaus Berger, Nicola Martinelli, Domenico Girelli, Pascal P McKeown, Christopher C Patterson, Stephen E Epstein, Joseph Devaney, Mary-Susan Burnett, Vincent Mooser, Samuli Ripatti, Ida Surakka, Markku S Nieminen, Juha Sinisalo, Marja-Liisa Lokki, Markus Perola, Aki Havulinna, Ulf de Faire, Bruna Gigante, Erik Ingelsson, Tanja Zeller, Philipp Wild, Paul I W de Bakker, Olaf H Klungel, Anke-Hilse Maitland-van der Zee, Bas J M Peters, Anthonius de Boer, Diederick E Grobbee, Pieter W Kamphuisen, Vera H M Deneer, Clara C Elbers, N Charlotte Onland-Moret, Marten H Hofker, Cisca Wijmenga, W M Monique Verschuren, Jolanda M A Boer, Yvonne T van der Schouw, Asif Rasheed, Philippe Frossard, Serkalem Demissie, Cristen Willer, Ron Do, Jose M Ordovas, Gonçalo R Abecasis, Michael Boehnke, Karen L Mohlke, Mark J Daly, Candace Guiducci, Noël P Burtt, Aarti Surti, Elena Gonzalez, Shaun Purcell, Stacey Gabriel, Jaume Marrugat, John Peden, Jeanette Erdmann, Patrick Diemert, Christina Willenborg, Inke R König, Marcus Fischer, Christian Hengstenberg, Andreas Ziegler, Ian Buysschaert, Diether Lambrechts, Frans Van de Werf, Keith A Fox, Nour Eddine El Mokhtari, Diana Rubin, Jürgen Schrezenmeir, Stefan Schreiber, Arne Schäfer, John Danesh, Stefan Blankenberg, Robert Roberts, Ruth McPherson, Hugh Watkins, Alistair S Hall, Kim Overvad, Eric Rimm, Eric Boerwinkle, Anne Tybjaerg-Hansen, L Adrienne Cupples, Muredach P Reilly, Olle Melander, Pier M Mannucci, Diego Ardissino, David Siscovick, Roberto Elosua, Kari Stefansson, Christopher J O'Donnell, Veikko Salomaa, Daniel J Rader, Leena Peltonen, Stephen M Schwartz, David Altshuler, Sekar Kathiresan

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

1904 Citationer (Scopus)

Abstract

High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendelian randomisation can be used to test the hypothesis that the association of a plasma biomarker with disease is causal.

Originalsprog	Engelsk
Tidsskrift	Lancet
Vol/bind	380
Udgave nummer	9841
Sider (fra-til)	572-80
Antal sider	9
ISSN	0140-6736
DOI	https://doi.org/10.1016/S0140-6736(12)60312-2
Status	Udgivet - 2012

Adgang til dokumentet

10.1016/S0140-6736(12)60312-2

Citationsformater

Voight, B. F., Peloso, G. M., Orho-Melander, M., Frikke-Schmidt, R., Barbalic, M., Jensen, M. K., Hindy, G., Hólm, H., Ding, E. L., Johnson, T., Schunkert, H., Samani, N. J., Clarke, R., Hopewell, J. C., Thompson, J. F., Li, M., Thorleifsson, G., Newton-Cheh, C., Musunuru, K., ... Kathiresan, S. (2012). Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet, 380(9841), 572-80. https://doi.org/10.1016/S0140-6736(12)60312-2

Voight, BF, Peloso, GM, Orho-Melander, M, Frikke-Schmidt, R, Barbalic, M, Jensen, MK, Hindy, G, Hólm, H, Ding, EL, Johnson, T, Schunkert, H, Samani, NJ, Clarke, R, Hopewell, JC, Thompson, JF, Li, M, Thorleifsson, G, Newton-Cheh, C, Musunuru, K, Pirruccello, JP, Saleheen, D, Chen, L, Stewart, AFR, Schillert, A, Thorsteinsdottir, U, Thorgeirsson, G, Anand, S, Engert, JC, Morgan, T, Spertus, J, Stoll, M, Berger, K, Martinelli, N, Girelli, D, McKeown, PP, Patterson, CC, Epstein, SE, Devaney, J, Burnett, M-S, Mooser, V, Ripatti, S, Surakka, I, Nieminen, MS, Sinisalo, J, Lokki, M-L, Perola, M, Havulinna, A, de Faire, U, Gigante, B, Ingelsson, E, Zeller, T, Wild, P, de Bakker, PIW, Klungel, OH, Maitland-van der Zee, A-H, Peters, BJM, de Boer, A, Grobbee, DE, Kamphuisen, PW, Deneer, VHM, Elbers, CC, Onland-Moret, NC, Hofker, MH, Wijmenga, C, Verschuren, WMM, Boer, JMA, van der Schouw, YT, Rasheed, A, Frossard, P, Demissie, S, Willer, C, Do, R, Ordovas, JM, Abecasis, GR, Boehnke, M, Mohlke, KL, Daly, MJ, Guiducci, C, Burtt, NP, Surti, A, Gonzalez, E, Purcell, S, Gabriel, S, Marrugat, J, Peden, J, Erdmann, J, Diemert, P, Willenborg, C, König, IR, Fischer, M, Hengstenberg, C, Ziegler, A, Buysschaert, I, Lambrechts, D, Van de Werf, F, Fox, KA, El Mokhtari, NE, Rubin, D, Schrezenmeir, J, Schreiber, S, Schäfer, A, Danesh, J, Blankenberg, S, Roberts, R, McPherson, R, Watkins, H, Hall, AS, Overvad, K, Rimm, E, Boerwinkle, E, Tybjaerg-Hansen, A, Cupples, LA, Reilly, MP, Melander, O, Mannucci, PM, Ardissino, D, Siscovick, D, Elosua, R, Stefansson, K, O'Donnell, CJ, Salomaa, V, Rader, DJ, Peltonen, L, Schwartz, SM, Altshuler, D & Kathiresan, S 2012, 'Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study', Lancet, bind 380, nr. 9841, s. 572-80. https://doi.org/10.1016/S0140-6736(12)60312-2

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abstract = "High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendelian randomisation can be used to test the hypothesis that the association of a plasma biomarker with disease is causal.",

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year = "2012",

doi = "10.1016/S0140-6736(12)60312-2",

language = "English",

volume = "380",

pages = "572--80",

journal = "Lancet",

issn = "0140-6736",

publisher = "TheLancet Publishing Group",

number = "9841",

}

TY - JOUR

T1 - Plasma HDL cholesterol and risk of myocardial infarction

T2 - a mendelian randomisation study

AU - Voight, Benjamin F

AU - Peloso, Gina M

AU - Orho-Melander, Marju

AU - Frikke-Schmidt, Ruth

AU - Barbalic, Maja

AU - Jensen, Majken Karoline

AU - Hindy, George

AU - Hólm, Hilma

AU - Ding, Eric L

AU - Johnson, Toby

AU - Schunkert, Heribert

AU - Samani, Nilesh J

AU - Clarke, Robert

AU - Hopewell, Jemma C

AU - Thompson, John F

AU - Li, Mingyao

AU - Thorleifsson, Gudmar

AU - Newton-Cheh, Christopher

AU - Musunuru, Kiran

AU - Pirruccello, James P

AU - Saleheen, Danish

AU - Chen, Li

AU - Stewart, Alexandre F R

AU - Schillert, Arne

AU - Thorsteinsdottir, Unnur

AU - Thorgeirsson, Gudmundur

AU - Anand, Sonia

AU - Engert, James C

AU - Morgan, Thomas

AU - Spertus, John

AU - Stoll, Monika

AU - Berger, Klaus

AU - Martinelli, Nicola

AU - Girelli, Domenico

AU - McKeown, Pascal P

AU - Patterson, Christopher C

AU - Epstein, Stephen E

AU - Devaney, Joseph

AU - Burnett, Mary-Susan

AU - Mooser, Vincent

AU - Ripatti, Samuli

AU - Surakka, Ida

AU - Nieminen, Markku S

AU - Sinisalo, Juha

AU - Lokki, Marja-Liisa

AU - Perola, Markus

AU - Havulinna, Aki

AU - de Faire, Ulf

AU - Gigante, Bruna

AU - Ingelsson, Erik

AU - Zeller, Tanja

AU - Wild, Philipp

AU - de Bakker, Paul I W

AU - Klungel, Olaf H

AU - Maitland-van der Zee, Anke-Hilse

AU - Peters, Bas J M

AU - de Boer, Anthonius

AU - Grobbee, Diederick E

AU - Kamphuisen, Pieter W

AU - Deneer, Vera H M

AU - Elbers, Clara C

AU - Onland-Moret, N Charlotte

AU - Hofker, Marten H

AU - Wijmenga, Cisca

AU - Verschuren, W M Monique

AU - Boer, Jolanda M A

AU - van der Schouw, Yvonne T

AU - Rasheed, Asif

AU - Frossard, Philippe

AU - Demissie, Serkalem

AU - Willer, Cristen

AU - Do, Ron

AU - Ordovas, Jose M

AU - Abecasis, Gonçalo R

AU - Boehnke, Michael

AU - Mohlke, Karen L

AU - Daly, Mark J

AU - Guiducci, Candace

AU - Burtt, Noël P

AU - Surti, Aarti

AU - Gonzalez, Elena

AU - Purcell, Shaun

AU - Gabriel, Stacey

AU - Marrugat, Jaume

AU - Peden, John

AU - Erdmann, Jeanette

AU - Diemert, Patrick

AU - Willenborg, Christina

AU - König, Inke R

AU - Fischer, Marcus

AU - Hengstenberg, Christian

AU - Ziegler, Andreas

AU - Buysschaert, Ian

AU - Lambrechts, Diether

AU - Van de Werf, Frans

AU - Fox, Keith A

AU - El Mokhtari, Nour Eddine

AU - Rubin, Diana

AU - Schrezenmeir, Jürgen

AU - Schreiber, Stefan

AU - Schäfer, Arne

AU - Danesh, John

AU - Blankenberg, Stefan

AU - Roberts, Robert

AU - McPherson, Ruth

AU - Watkins, Hugh

AU - Hall, Alistair S

AU - Overvad, Kim

AU - Rimm, Eric

AU - Boerwinkle, Eric

AU - Tybjaerg-Hansen, Anne

AU - Cupples, L Adrienne

AU - Reilly, Muredach P

AU - Melander, Olle

AU - Mannucci, Pier M

AU - Ardissino, Diego

AU - Siscovick, David

AU - Elosua, Roberto

AU - Stefansson, Kari

AU - O'Donnell, Christopher J

AU - Salomaa, Veikko

AU - Rader, Daniel J

AU - Peltonen, Leena

AU - Schwartz, Stephen M

AU - Altshuler, David

AU - Kathiresan, Sekar

PY - 2012

Y1 - 2012

N2 - High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendelian randomisation can be used to test the hypothesis that the association of a plasma biomarker with disease is causal.

AB - High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendelian randomisation can be used to test the hypothesis that the association of a plasma biomarker with disease is causal.

U2 - 10.1016/S0140-6736(12)60312-2

DO - 10.1016/S0140-6736(12)60312-2

M3 - Journal article

SN - 0140-6736

VL - 380

SP - 572

EP - 580

JO - Lancet

JF - Lancet

IS - 9841

ER -