Plasma NGAL, suPAR, KIM-1 and GDF-15 for Improving Glomerular Filtration Rate Estimation in Older Hospitalized Patients

Morten Baltzer Houlind; Alberte Linnet Nielsen; Anne Byriel Walls; Louise Westberg Strejby Christensen; Rikke Lundsgaard Nielsen; Aino Andersen; Baker Nawfal Jawad; Ove Andersen; Morten Damgaard; Esben Iversen; Juliette Tavenier; Helle Gybel Juul-Larsen

doi:10.1111/bcpt.70002

Plasma NGAL, suPAR, KIM-1 and GDF-15 for Improving Glomerular Filtration Rate Estimation in Older Hospitalized Patients

Morten Baltzer Houlind^*, Alberte Linnet Nielsen, Anne Byriel Walls, Louise Westberg Strejby Christensen, Rikke Lundsgaard Nielsen, Aino Andersen, Baker Nawfal Jawad, Ove Andersen, Morten Damgaard, Esben Iversen, Juliette Tavenier, Helle Gybel Juul-Larsen

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Accurate glomerular filtration rate (GFR) estimation is crucial for diagnosing kidney disease and prescribing renal risk medications [1-3]. In clinical practice, estimated GFR (eGFR) is typically determined by plasma creatinine levels adjusted for age and sex (eGFRcre) [4]. However, creatinine is an imperfect metric of GFR, particularly in older (age ≥ 65 years) hospitalized patients, due to age-related changes in non-GFR factors such as muscle mass and nutritional status that affect creatinine level [5]. The addition of cystatin C to creatinine (eGFRcomb) improves the accuracy of GFR estimates for older hospitalized patients, but there remains a large and unpredictable margin of error compared with measured GFR (mGFR)

Originalsprog	Engelsk
Artikelnummer	e70002
Tidsskrift	Basic and Clinical Pharmacology and Toxicology
Vol/bind	136
Udgave nummer	3
Antal sider	3
ISSN	1742-7835
DOI	https://doi.org/10.1111/bcpt.70002
Status	Udgivet - 2025

Adgang til dokumentet

10.1111/bcpt.70002Licens: CC BY-NC-ND

FulltextForlagets udgivne version, 139 KBLicens: CC BY-NC-ND

Citationsformater

Houlind, MB., Nielsen, AL., Walls, AB., Christensen, LWS., Nielsen, RL., Andersen, A., Jawad, BN., Andersen, O., Damgaard, M., Iversen, E., Tavenier, J., & Juul-Larsen, HG. (2025). Plasma NGAL, suPAR, KIM-1 and GDF-15 for Improving Glomerular Filtration Rate Estimation in Older Hospitalized Patients. Basic and Clinical Pharmacology and Toxicology, 136(3), [e70002]. https://doi.org/10.1111/bcpt.70002

Plasma NGAL, suPAR, KIM-1 and GDF-15 for Improving Glomerular Filtration Rate Estimation in Older Hospitalized Patients. / Houlind, Morten Baltzer; Nielsen, Alberte Linnet; Walls, Anne Byriel; Christensen, Louise Westberg Strejby; Nielsen, Rikke Lundsgaard; Andersen, Aino; Jawad, Baker Nawfal; Andersen, Ove ; Damgaard, Morten; Iversen, Esben; Tavenier, Juliette; Juul-Larsen, Helle Gybel.

I: Basic and Clinical Pharmacology and Toxicology, Bind 136, Nr. 3, e70002, 2025.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Houlind, MB, Nielsen, AL, Walls, AB, Christensen, LWS, Nielsen, RL, Andersen, A, Jawad, BN, Andersen, O , Damgaard, M, Iversen, E, Tavenier, J & Juul-Larsen, HG 2025, 'Plasma NGAL, suPAR, KIM-1 and GDF-15 for Improving Glomerular Filtration Rate Estimation in Older Hospitalized Patients', Basic and Clinical Pharmacology and Toxicology, bind 136, nr. 3, e70002. https://doi.org/10.1111/bcpt.70002

Houlind, Morten Baltzer ; Nielsen, Alberte Linnet ; Walls, Anne Byriel ; Christensen, Louise Westberg Strejby ; Nielsen, Rikke Lundsgaard ; Andersen, Aino ; Jawad, Baker Nawfal ; Andersen, Ove ; Damgaard, Morten ; Iversen, Esben ; Tavenier, Juliette ; Juul-Larsen, Helle Gybel. / Plasma NGAL, suPAR, KIM-1 and GDF-15 for Improving Glomerular Filtration Rate Estimation in Older Hospitalized Patients. I: Basic and Clinical Pharmacology and Toxicology. 2025 ; Bind 136, Nr. 3.

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abstract = "Accurate glomerular filtration rate (GFR) estimation is crucial for diagnosing kidney disease and prescribing renal risk medications [1-3]. In clinical practice, estimated GFR (eGFR) is typically determined by plasma creatinine levels adjusted for age and sex (eGFRcre) [4]. However, creatinine is an imperfect metric of GFR, particularly in older (age ≥ 65 years) hospitalized patients, due to age-related changes in non-GFR factors such as muscle mass and nutritional status that affect creatinine level [5]. The addition of cystatin C to creatinine (eGFRcomb) improves the accuracy of GFR estimates for older hospitalized patients, but there remains a large and unpredictable margin of error compared with measured GFR (mGFR)",

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AU - Houlind, Morten Baltzer

AU - Nielsen, Alberte Linnet

AU - Walls, Anne Byriel

AU - Christensen, Louise Westberg Strejby

AU - Nielsen, Rikke Lundsgaard

AU - Andersen, Aino

AU - Jawad, Baker Nawfal

AU - Andersen, Ove

AU - Damgaard, Morten

AU - Iversen, Esben

AU - Tavenier, Juliette

AU - Juul-Larsen, Helle Gybel

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AB - Accurate glomerular filtration rate (GFR) estimation is crucial for diagnosing kidney disease and prescribing renal risk medications [1-3]. In clinical practice, estimated GFR (eGFR) is typically determined by plasma creatinine levels adjusted for age and sex (eGFRcre) [4]. However, creatinine is an imperfect metric of GFR, particularly in older (age ≥ 65 years) hospitalized patients, due to age-related changes in non-GFR factors such as muscle mass and nutritional status that affect creatinine level [5]. The addition of cystatin C to creatinine (eGFRcomb) improves the accuracy of GFR estimates for older hospitalized patients, but there remains a large and unpredictable margin of error compared with measured GFR (mGFR)

KW - biomarkers

KW - kidney/renal toxicology

KW - pharmacokinetics

KW - renal excretion of drugs

KW - renal impairment and drug treatment

KW - safety evaluation

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DO - 10.1111/bcpt.70002

M3 - Journal article

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JO - Basic and Clinical Pharmacology and Toxicology

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