Polypharmacy and the risk of drug-drug interactions among Danish elderly: A prescription database study

J U Rosholm; L Bjerrum; J Hallas; J Worm; L F Gram

Polypharmacy and the risk of drug-drug interactions among Danish elderly: A prescription database study

J U Rosholm, L Bjerrum, J Hallas, J Worm, L F Gram

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

96 Citationer (Scopus)

Abstract

Udgivelsesdato: 1998-Apr

Originalsprog	Engelsk
Tidsskrift	Danish Medical Bulletin
Vol/bind	45
Udgave nummer	2
Sider (fra-til)	210-213
Antal sider	3
ISSN	0907-8916
Status	Udgivet - 1998
Udgivet eksternt	Ja

Citationsformater

@article{7eb4ada031c611df8ed1000ea68e967b,

title = "Polypharmacy and the risk of drug-drug interactions among Danish elderly: A prescription database study",

abstract = "OBJECTIVE: To analyze the use of all subsidized prescription drugs with special attention to the elderly (> or = 70 years of age), including their use of drug combination generally accepted as carrying a risk of severe interactions. DESIGN: Descriptive prevalence study. SETTING: Odense Pharmacoepidemiological Database, Denmark. The fourth quarter of 1994. SUBJECTS: All inhabitants in the county of Funen, Denmark. MAIN OUTCOME MEASURES: Prevalence of drug use for persons < 70 and > or = 70 years of age including number of drugs used and of drug combinations. Occurrence of 45 drug combinations generally accepted as carrying a risk of severe interactions. RESULTS: Among persons less than 70 years, 67.9% used none, 16.5% used one drug and 15.6% used two or more prescription drugs. The corresponding prevalences for the elderly were 35.7%, 15.9% and 48.4%. The 26,337 elderly patients with at least two drugs used 21,293 different combinations. Of the elderly patients who had purchased > or = two drugs, 4.4% had combinations of drugs carrying a risk of severe interactions. CONCLUSIONS: Most elderly use drugs and usually several drugs concomitantly. The elderly form a heterogeneous group of drug users. Drug combinations carrying a risk of severe interactions are relatively frequent.",

author = "Rosholm, {J U} and L Bjerrum and J Hallas and J Worm and Gram, {L F}",

year = "1998",

language = "English",

volume = "45",

pages = "210--213",

journal = "Danish Medical Bulletin",

issn = "0907-8916",

publisher = "Almindelige Danske Laegeforening",

number = "2",

}

TY - JOUR

T1 - Polypharmacy and the risk of drug-drug interactions among Danish elderly

T2 - A prescription database study

AU - Rosholm, J U

AU - Bjerrum, L

AU - Hallas, J

AU - Worm, J

AU - Gram, L F

PY - 1998

Y1 - 1998

N2 - OBJECTIVE: To analyze the use of all subsidized prescription drugs with special attention to the elderly (> or = 70 years of age), including their use of drug combination generally accepted as carrying a risk of severe interactions. DESIGN: Descriptive prevalence study. SETTING: Odense Pharmacoepidemiological Database, Denmark. The fourth quarter of 1994. SUBJECTS: All inhabitants in the county of Funen, Denmark. MAIN OUTCOME MEASURES: Prevalence of drug use for persons < 70 and > or = 70 years of age including number of drugs used and of drug combinations. Occurrence of 45 drug combinations generally accepted as carrying a risk of severe interactions. RESULTS: Among persons less than 70 years, 67.9% used none, 16.5% used one drug and 15.6% used two or more prescription drugs. The corresponding prevalences for the elderly were 35.7%, 15.9% and 48.4%. The 26,337 elderly patients with at least two drugs used 21,293 different combinations. Of the elderly patients who had purchased > or = two drugs, 4.4% had combinations of drugs carrying a risk of severe interactions. CONCLUSIONS: Most elderly use drugs and usually several drugs concomitantly. The elderly form a heterogeneous group of drug users. Drug combinations carrying a risk of severe interactions are relatively frequent.

AB - OBJECTIVE: To analyze the use of all subsidized prescription drugs with special attention to the elderly (> or = 70 years of age), including their use of drug combination generally accepted as carrying a risk of severe interactions. DESIGN: Descriptive prevalence study. SETTING: Odense Pharmacoepidemiological Database, Denmark. The fourth quarter of 1994. SUBJECTS: All inhabitants in the county of Funen, Denmark. MAIN OUTCOME MEASURES: Prevalence of drug use for persons < 70 and > or = 70 years of age including number of drugs used and of drug combinations. Occurrence of 45 drug combinations generally accepted as carrying a risk of severe interactions. RESULTS: Among persons less than 70 years, 67.9% used none, 16.5% used one drug and 15.6% used two or more prescription drugs. The corresponding prevalences for the elderly were 35.7%, 15.9% and 48.4%. The 26,337 elderly patients with at least two drugs used 21,293 different combinations. Of the elderly patients who had purchased > or = two drugs, 4.4% had combinations of drugs carrying a risk of severe interactions. CONCLUSIONS: Most elderly use drugs and usually several drugs concomitantly. The elderly form a heterogeneous group of drug users. Drug combinations carrying a risk of severe interactions are relatively frequent.

M3 - Journal article

C2 - 9587704

SN - 0907-8916

VL - 45

SP - 210

EP - 213

JO - Danish Medical Bulletin

JF - Danish Medical Bulletin

IS - 2

ER -