Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2

Daxi Wang; Yanqun Wang; Wanying Sun; Lu Zhang; Jingkai Ji; Zhaoyong Zhang; Xinyi Cheng; Yimin Li; Fei Xiao; Airu Zhu; Bei Zhong; Shicong Ruan; Jiandong Li; Peidi Ren; Zhihua Ou; Minfeng Xiao; Min Li; Ziqing Deng; Huanzi Zhong; Fuqiang Li; Wen-jing Wang; Yongwei Zhang; Weijun Chen; Shida Zhu; Xun Xu; Xin Jin; Jingxian Zhao; Nanshan Zhong; Wenwei Zhang; Jincun Zhao; Junhua Li; Yonghao Xu

doi:10.3389/fmed.2021.585358

Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2

Daxi Wang, Yanqun Wang, Wanying Sun, Lu Zhang, Jingkai Ji, Zhaoyong Zhang, Xinyi Cheng, Yimin Li, Fei Xiao, Airu Zhu, Bei Zhong, Shicong Ruan, Jiandong Li, Peidi Ren, Zhihua Ou, Minfeng Xiao, Min Li, Ziqing Deng, Huanzi Zhong, Fuqiang LiWen-jing Wang, Yongwei Zhang, Weijun Chen, Shida Zhu, Xun Xu, Xin Jin, Jingxian Zhao, Nanshan Zhong, Wenwei Zhang^*, Jincun Zhao, Junhua Li, Yonghao Xu

^*Corresponding author af dette arbejde

Genomforskning og Molekylær Biomedicin

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

25 Citationer (Scopus)

89 Downloads (Pure)

Abstract

The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 among COVID-19 patients within and across households. Our work showed an active viral replication activity in the human respiratory tract and the co-existence of genetically distinct viruses within the same host. The inter-host comparison among viral populations further revealed a narrow transmission bottleneck between patients from the same households, suggesting a dominated role of stochastic dynamics in both inter-host and intra-host evolutions.

Originalsprog	Engelsk
Artikelnummer	585358
Tidsskrift	Frontiers in Medicine
Vol/bind	8
Antal sider	7
ISSN	2296-858X
DOI	https://doi.org/10.3389/fmed.2021.585358
Status	Udgivet - 2021

Adgang til dokumentet

10.3389/fmed.2021.585358Licens: CC BY

Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2Forlagets udgivne version, 758 KBLicens: CC BY

Citationsformater

Wang, D., Wang, Y., Sun, W., Zhang, L., Ji, J., Zhang, Z., Cheng, X., Li, Y., Xiao, F., Zhu, A., Zhong, B., Ruan, S., Li, J., Ren, P., Ou, Z., Xiao, M., Li, M., Deng, Z., Zhong, H., ... Xu, Y. (2021). Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2. Frontiers in Medicine, 8, Artikel 585358. https://doi.org/10.3389/fmed.2021.585358

Wang, D, Wang, Y, Sun, W, Zhang, L, Ji, J, Zhang, Z, Cheng, X, Li, Y, Xiao, F, Zhu, A, Zhong, B, Ruan, S, Li, J, Ren, P, Ou, Z, Xiao, M, Li, M, Deng, Z, Zhong, H, Li, F, Wang, W, Zhang, Y, Chen, W, Zhu, S, Xu, X, Jin, X, Zhao, J, Zhong, N, Zhang, W, Zhao, J, Li, J & Xu, Y 2021, 'Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2', Frontiers in Medicine, bind 8, 585358. https://doi.org/10.3389/fmed.2021.585358

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title = "Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2",

abstract = "The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 among COVID-19 patients within and across households. Our work showed an active viral replication activity in the human respiratory tract and the co-existence of genetically distinct viruses within the same host. The inter-host comparison among viral populations further revealed a narrow transmission bottleneck between patients from the same households, suggesting a dominated role of stochastic dynamics in both inter-host and intra-host evolutions.",

keywords = "evolution, human to human transmission, intra-host variation, population bottleneck, SARS-CoV-2",

author = "Daxi Wang and Yanqun Wang and Wanying Sun and Lu Zhang and Jingkai Ji and Zhaoyong Zhang and Xinyi Cheng and Yimin Li and Fei Xiao and Airu Zhu and Bei Zhong and Shicong Ruan and Jiandong Li and Peidi Ren and Zhihua Ou and Minfeng Xiao and Min Li and Ziqing Deng and Huanzi Zhong and Fuqiang Li and Wen-jing Wang and Yongwei Zhang and Weijun Chen and Shida Zhu and Xun Xu and Xin Jin and Jingxian Zhao and Nanshan Zhong and Wenwei Zhang and Jincun Zhao and Junhua Li and Yonghao Xu",

year = "2021",

doi = "10.3389/fmed.2021.585358",

language = "English",

volume = "8",

journal = "Frontiers in Medicine",

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TY - JOUR

T1 - Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2

AU - Wang, Daxi

AU - Wang, Yanqun

AU - Sun, Wanying

AU - Zhang, Lu

AU - Ji, Jingkai

AU - Zhang, Zhaoyong

AU - Cheng, Xinyi

AU - Li, Yimin

AU - Xiao, Fei

AU - Zhu, Airu

AU - Zhong, Bei

AU - Ruan, Shicong

AU - Li, Jiandong

AU - Ren, Peidi

AU - Ou, Zhihua

AU - Xiao, Minfeng

AU - Li, Min

AU - Deng, Ziqing

AU - Zhong, Huanzi

AU - Li, Fuqiang

AU - Wang, Wen-jing

AU - Zhang, Yongwei

AU - Chen, Weijun

AU - Zhu, Shida

AU - Xu, Xun

AU - Jin, Xin

AU - Zhao, Jingxian

AU - Zhong, Nanshan

AU - Zhang, Wenwei

AU - Zhao, Jincun

AU - Li, Junhua

AU - Xu, Yonghao

PY - 2021

Y1 - 2021

N2 - The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 among COVID-19 patients within and across households. Our work showed an active viral replication activity in the human respiratory tract and the co-existence of genetically distinct viruses within the same host. The inter-host comparison among viral populations further revealed a narrow transmission bottleneck between patients from the same households, suggesting a dominated role of stochastic dynamics in both inter-host and intra-host evolutions.

AB - The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 among COVID-19 patients within and across households. Our work showed an active viral replication activity in the human respiratory tract and the co-existence of genetically distinct viruses within the same host. The inter-host comparison among viral populations further revealed a narrow transmission bottleneck between patients from the same households, suggesting a dominated role of stochastic dynamics in both inter-host and intra-host evolutions.

KW - evolution

KW - human to human transmission

KW - intra-host variation

KW - population bottleneck

KW - SARS-CoV-2

U2 - 10.3389/fmed.2021.585358

DO - 10.3389/fmed.2021.585358

M3 - Journal article

C2 - 33659260

AN - SCOPUS:85101935416

SN - 2296-858X

VL - 8

JO - Frontiers in Medicine

JF - Frontiers in Medicine

M1 - 585358

ER -