Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics.

D F Wong; H N Wagner; L E Tune; R F Dannals; G D Pearlson; J M Links; C A Tamminga; E P Broussolle; H T Ravert; A A Wilson; J K Toung; J Malat; J A Williams; L A O'Tuama; S H Snyder; M J Kuhar; A Gjedde

Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics.

D F Wong, H N Wagner, L E Tune, R F Dannals, G D Pearlson, J M Links, C A Tamminga, E P Broussolle, H T Ravert, A A Wilson, J K Toung, J Malat, J A Williams, L A O'Tuama, S H Snyder, M J Kuhar, A Gjedde

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

714 Citationer (Scopus)

Abstract

Udgivelsesdato: 1986-Dec-19

Originalsprog	Engelsk
Tidsskrift	Science
Vol/bind	234
Udgave nummer	4783
Sider (fra-til)	1558-63
Antal sider	5
ISSN	0036-8075
Status	Udgivet - 1986
Udgivet eksternt	Ja

Citationsformater

Wong, D. F., Wagner, H. N., Tune, L. E., Dannals, R. F., Pearlson, G. D., Links, J. M., Tamminga, C. A., Broussolle, E. P., Ravert, H. T., Wilson, A. A., Toung, J. K., Malat, J., Williams, J. A., O'Tuama, L. A., Snyder, S. H., Kuhar, M. J., & Gjedde, A. (1986). Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics. Science, 234(4783), 1558-63.

@article{13067910b31511debc73000ea68e967b,

title = "Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics.",

abstract = "In postmortem studies of patients with schizophrenia, D2 dopamine receptors in the basal ganglia have been observed to be more numerous than in patients with no history of neurological or psychiatric disease. Because most patients with schizophrenia are treated with neuroleptic drugs that block D2 dopamine receptors in the caudate nucleus, it has been suggested that this increase in the number of receptors is a result of adaptation to these drugs rather than a biochemical abnormality intrinsic to schizophrenia. With positron emission tomography (PET), the D2 dopamine receptor density in the caudate nucleus of living human beings was measured in normal volunteers and in two groups of patients with schizophrenia--one group that had never been treated with neuroleptics and another group that had been treated with these drugs. D2 dopamine receptor densities in the caudate nucleus were higher in both groups of patients than in the normal volunteers. Thus, schizophrenia itself is associated with an increase in brain D2 dopamine receptor density.",

author = "Wong, {D F} and Wagner, {H N} and Tune, {L E} and Dannals, {R F} and Pearlson, {G D} and Links, {J M} and Tamminga, {C A} and Broussolle, {E P} and Ravert, {H T} and Wilson, {A A} and Toung, {J K} and J Malat and Williams, {J A} and O'Tuama, {L A} and Snyder, {S H} and Kuhar, {M J} and A Gjedde",

year = "1986",

language = "English",

volume = "234",

pages = "1558--63",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4783",

}

TY - JOUR

T1 - Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics.

AU - Wong, D F

AU - Wagner, H N

AU - Tune, L E

AU - Dannals, R F

AU - Pearlson, G D

AU - Links, J M

AU - Tamminga, C A

AU - Broussolle, E P

AU - Ravert, H T

AU - Wilson, A A

AU - Toung, J K

AU - Malat, J

AU - Williams, J A

AU - O'Tuama, L A

AU - Snyder, S H

AU - Kuhar, M J

AU - Gjedde, A

PY - 1986

Y1 - 1986

N2 - In postmortem studies of patients with schizophrenia, D2 dopamine receptors in the basal ganglia have been observed to be more numerous than in patients with no history of neurological or psychiatric disease. Because most patients with schizophrenia are treated with neuroleptic drugs that block D2 dopamine receptors in the caudate nucleus, it has been suggested that this increase in the number of receptors is a result of adaptation to these drugs rather than a biochemical abnormality intrinsic to schizophrenia. With positron emission tomography (PET), the D2 dopamine receptor density in the caudate nucleus of living human beings was measured in normal volunteers and in two groups of patients with schizophrenia--one group that had never been treated with neuroleptics and another group that had been treated with these drugs. D2 dopamine receptor densities in the caudate nucleus were higher in both groups of patients than in the normal volunteers. Thus, schizophrenia itself is associated with an increase in brain D2 dopamine receptor density.

AB - In postmortem studies of patients with schizophrenia, D2 dopamine receptors in the basal ganglia have been observed to be more numerous than in patients with no history of neurological or psychiatric disease. Because most patients with schizophrenia are treated with neuroleptic drugs that block D2 dopamine receptors in the caudate nucleus, it has been suggested that this increase in the number of receptors is a result of adaptation to these drugs rather than a biochemical abnormality intrinsic to schizophrenia. With positron emission tomography (PET), the D2 dopamine receptor density in the caudate nucleus of living human beings was measured in normal volunteers and in two groups of patients with schizophrenia--one group that had never been treated with neuroleptics and another group that had been treated with these drugs. D2 dopamine receptor densities in the caudate nucleus were higher in both groups of patients than in the normal volunteers. Thus, schizophrenia itself is associated with an increase in brain D2 dopamine receptor density.

M3 - Journal article

C2 - 2878495

SN - 0036-8075

VL - 234

SP - 1558

EP - 1563

JO - Science

JF - Science

IS - 4783

ER -