Poststroke Translocator Protein Expression Dynamics and Correlations to Chronic Infarction: A [123I]-CLINDE-SPECT Study

Per Jensen; Brice Ozenne; Per Meden; Ling Feng; Gerda Thomsen; Lars Knudsen; Henrik Steglich-Arnholm; Kirsten Møller; Carsten Thomsen; Claus Svarer; Vincent Beliveau; Jens Mikkelsen; Gitte Knudsen; Lars H Pinborg

doi:10.1111/jon.70002

Poststroke Translocator Protein Expression Dynamics and Correlations to Chronic Infarction: A [123I]-CLINDE-SPECT Study

Per Jensen, Brice Ozenne, Per Meden, Ling Feng, Gerda Thomsen, Lars Knudsen, Henrik Steglich-Arnholm, Kirsten Møller, Carsten Thomsen, Claus Svarer, Vincent Beliveau, Jens Mikkelsen, Gitte Knudsen, Lars H Pinborg

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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Abstract

Background and Purpose
This study aims to investigate the longitudinal changes in translocator protein (TSPO) following stroke in different brain regions and potential associations with chronic brain infarction.

Methods
Twelve patients underwent SPECT using the TSPO tracer 6-Chloro-2-(4ʹ-123I-Iodophenyl)-3-(N,N-Diethyl)-Imidazo[1,2-a]Pyridine-3-Acetamide, as well as structural MRI, at 10, 41, and 128 days (median) after ischemic infarction in the middle cerebral artery. TSPO expression was measured in lesional (MRI lesion and SPECT lesion), connected (pons and ipsilesional thalamus), and nonconnected (ipsilesional cerebellum and contralesional occipital cortex) regions. Correlations were explored between the volume of chronic infarction and TSPO expression in nonconnected regions of interest (ROIs) at 128 days

Results
Throughout the study period, TSPO levels decreased by 24%–33% in lesional ROIs, while levels increased in connected ROIs by 35%–69% and in nonconnected ROIs by 53%–77%. At 128 days poststroke, TSPO expression in ipsilesional cerebellum positively correlated with chronic infarction volume (p = 0.002, r2 = 0.72).

Conclusions
This study expands the current knowledge of spatial and temporal TSPO expression in humans by quantifying TSPO changes in lesional, connected, and nonconnected brain regions at three time points after cerebral infarction as well as correlating late-stage TSPO upregulation and chronic infarction volume.

Originalsprog	Engelsk
Artikelnummer	e70002
Tidsskrift	Journal of Neuroimaging
Vol/bind	35
Udgave nummer	1
Antal sider	10
ISSN	1051-2284
DOI	https://doi.org/10.1111/jon.70002
Status	Udgivet - 2025

Bibliografisk note

Adgang til dokumentet

10.1111/jon.70002Licens: CC BY

FulltextForlagets udgivne version, 1,2 MBLicens: CC BY

Citationsformater

Jensen, P., Ozenne, B., Meden, P., Feng, L., Thomsen, G., Knudsen, L., Steglich-Arnholm, H., Møller, K., Thomsen, C., Svarer, C., Beliveau, V., Mikkelsen, J., Knudsen, G., & H Pinborg, L. (2025). Poststroke Translocator Protein Expression Dynamics and Correlations to Chronic Infarction: A [123I]-CLINDE-SPECT Study. Journal of Neuroimaging, 35(1), Artikel e70002. https://doi.org/10.1111/jon.70002

Jensen, P, Ozenne, B , Meden, P, Feng, L, Thomsen, G, Knudsen, L, Steglich-Arnholm, H, Møller, K, Thomsen, C, Svarer, C, Beliveau, V, Mikkelsen, J, Knudsen, G & H Pinborg, L 2025, 'Poststroke Translocator Protein Expression Dynamics and Correlations to Chronic Infarction: A [123I]-CLINDE-SPECT Study', Journal of Neuroimaging, bind 35, nr. 1, e70002. https://doi.org/10.1111/jon.70002

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title = "Poststroke Translocator Protein Expression Dynamics and Correlations to Chronic Infarction: A [123I]-CLINDE-SPECT Study",

abstract = "BACKGROUND AND PURPOSE: This study aims to investigate the longitudinal changes in translocator protein (TSPO) following stroke in different brain regions and potential associations with chronic brain infarction.METHODS: Twelve patients underwent SPECT using the TSPO tracer 6-Chloro-2-(4'-123I-Iodophenyl)-3-(N,N-Diethyl)-Imidazo[1,2-a]Pyridine-3-Acetamide, as well as structural MRI, at 10, 41, and 128 days (median) after ischemic infarction in the middle cerebral artery. TSPO expression was measured in lesional (MRI lesion and SPECT lesion), connected (pons and ipsilesional thalamus), and nonconnected (ipsilesional cerebellum and contralesional occipital cortex) regions. Correlations were explored between the volume of chronic infarction and TSPO expression in nonconnected regions of interest (ROIs) at 128 days RESULTS: Throughout the study period, TSPO levels decreased by 24%-33% in lesional ROIs, while levels increased in connected ROIs by 35%-69% and in nonconnected ROIs by 53%-77%. At 128 days poststroke, TSPO expression in ipsilesional cerebellum positively correlated with chronic infarction volume (p = 0.002, r2 = 0.72).CONCLUSIONS: This study expands the current knowledge of spatial and temporal TSPO expression in humans by quantifying TSPO changes in lesional, connected, and nonconnected brain regions at three time points after cerebral infarction as well as correlating late-stage TSPO upregulation and chronic infarction volume.",

keywords = "Humans, Male, Female, Receptors, GABA/metabolism, Aged, Middle Aged, Tomography, Emission-Computed, Single-Photon/methods, Chronic Disease, Brain/metabolism, Stroke/diagnostic imaging, Magnetic Resonance Imaging/methods, Radiopharmaceuticals, Pyridines, Bridged Bicyclo Compounds, Heterocyclic",

author = "Per Jensen and Brice Ozenne and Per Meden and Ling Feng and Gerda Thomsen and Lars Knudsen and Henrik Steglich-Arnholm and Kirsten M{\o}ller and Carsten Thomsen and Claus Svarer and Vincent Beliveau and Jens Mikkelsen and Gitte Knudsen and {H Pinborg}, Lars",

note = "{\textcopyright} 2025 The Author(s). Journal of Neuroimaging published by Wiley Periodicals LLC on behalf of American Society of Neuroimaging.",

year = "2025",

doi = "10.1111/jon.70002",

language = "English",

volume = "35",

journal = "Journal of Neuroimaging",

issn = "1051-2284",

publisher = "Wiley-Blackwell",

number = "1",

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TY - JOUR

T1 - Poststroke Translocator Protein Expression Dynamics and Correlations to Chronic Infarction

T2 - A [123I]-CLINDE-SPECT Study

AU - Jensen, Per

AU - Ozenne, Brice

AU - Meden, Per

AU - Feng, Ling

AU - Thomsen, Gerda

AU - Knudsen, Lars

AU - Steglich-Arnholm, Henrik

AU - Møller, Kirsten

AU - Thomsen, Carsten

AU - Svarer, Claus

AU - Beliveau, Vincent

AU - Mikkelsen, Jens

AU - Knudsen, Gitte

AU - H Pinborg, Lars

PY - 2025

Y1 - 2025

N2 - BACKGROUND AND PURPOSE: This study aims to investigate the longitudinal changes in translocator protein (TSPO) following stroke in different brain regions and potential associations with chronic brain infarction.METHODS: Twelve patients underwent SPECT using the TSPO tracer 6-Chloro-2-(4'-123I-Iodophenyl)-3-(N,N-Diethyl)-Imidazo[1,2-a]Pyridine-3-Acetamide, as well as structural MRI, at 10, 41, and 128 days (median) after ischemic infarction in the middle cerebral artery. TSPO expression was measured in lesional (MRI lesion and SPECT lesion), connected (pons and ipsilesional thalamus), and nonconnected (ipsilesional cerebellum and contralesional occipital cortex) regions. Correlations were explored between the volume of chronic infarction and TSPO expression in nonconnected regions of interest (ROIs) at 128 days RESULTS: Throughout the study period, TSPO levels decreased by 24%-33% in lesional ROIs, while levels increased in connected ROIs by 35%-69% and in nonconnected ROIs by 53%-77%. At 128 days poststroke, TSPO expression in ipsilesional cerebellum positively correlated with chronic infarction volume (p = 0.002, r2 = 0.72).CONCLUSIONS: This study expands the current knowledge of spatial and temporal TSPO expression in humans by quantifying TSPO changes in lesional, connected, and nonconnected brain regions at three time points after cerebral infarction as well as correlating late-stage TSPO upregulation and chronic infarction volume.

AB - BACKGROUND AND PURPOSE: This study aims to investigate the longitudinal changes in translocator protein (TSPO) following stroke in different brain regions and potential associations with chronic brain infarction.METHODS: Twelve patients underwent SPECT using the TSPO tracer 6-Chloro-2-(4'-123I-Iodophenyl)-3-(N,N-Diethyl)-Imidazo[1,2-a]Pyridine-3-Acetamide, as well as structural MRI, at 10, 41, and 128 days (median) after ischemic infarction in the middle cerebral artery. TSPO expression was measured in lesional (MRI lesion and SPECT lesion), connected (pons and ipsilesional thalamus), and nonconnected (ipsilesional cerebellum and contralesional occipital cortex) regions. Correlations were explored between the volume of chronic infarction and TSPO expression in nonconnected regions of interest (ROIs) at 128 days RESULTS: Throughout the study period, TSPO levels decreased by 24%-33% in lesional ROIs, while levels increased in connected ROIs by 35%-69% and in nonconnected ROIs by 53%-77%. At 128 days poststroke, TSPO expression in ipsilesional cerebellum positively correlated with chronic infarction volume (p = 0.002, r2 = 0.72).CONCLUSIONS: This study expands the current knowledge of spatial and temporal TSPO expression in humans by quantifying TSPO changes in lesional, connected, and nonconnected brain regions at three time points after cerebral infarction as well as correlating late-stage TSPO upregulation and chronic infarction volume.

KW - Humans

KW - Male

KW - Female

KW - Receptors, GABA/metabolism

KW - Aged

KW - Middle Aged

KW - Tomography, Emission-Computed, Single-Photon/methods

KW - Chronic Disease

KW - Brain/metabolism

KW - Stroke/diagnostic imaging

KW - Magnetic Resonance Imaging/methods

KW - Radiopharmaceuticals

KW - Pyridines

KW - Bridged Bicyclo Compounds, Heterocyclic

U2 - 10.1111/jon.70002

DO - 10.1111/jon.70002

M3 - Journal article

C2 - 39803801

SN - 1051-2284

VL - 35

JO - Journal of Neuroimaging

JF - Journal of Neuroimaging

IS - 1

M1 - e70002

ER -