Pre-operative seizures in patients with single brain metastasis treated with resection plus whole-brain irradiation and a boost

Dirk Rades*, Jaspar Witteler, Troels W. Kjaer, Soeren Tvilsted, Steven E. Schild

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

2 Citationer (Scopus)
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Abstract

Background/Aim: Seizures can be the initial symptom of brain metastases. This study investigated pretreatment seizures in patients with a single lesion. Patients and Methods: Pre-operative seizures were analyzed in 104 patients with a single brain metastasis receiving resection plus whole-brain irradiation and a boost. Prevalence of seizures, risk factors and associations with survival (OS) were evaluated. Results: Thirty patients (34.6%) had seizures prior to neurosurgery. Significant associations between seizures and investigated characteristics were not found. However, age =61 years showed a trend (p=0.117) for increased incidence of seizures. Time from diagnosis of malignancy until neurosurgery >12 months was significantly associated with improved OS on univariate analysis (p=0.003). Trends for a positive association with OS were found for no seizures (p=0.054), female gender (p=0.066) and breast cancer (p=0.098). On multivariate analysis, time until neurosurgery >12 months was independently associated (p=0.019) with better OS, and seizures showed a trend (p=0.119) for improved OS. Conclusions: Considering the high prevalence of seizures in this cohort, regular screening and monitoring of these patients appears reasonable. This applies particularly to patients aged ≤61 years.

OriginalsprogEngelsk
TidsskriftIn Vivo
Vol/bind34
Udgave nummer5
Sider (fra-til)2705-2709
Antal sider5
ISSN0258-851X
DOI
StatusUdgivet - 2020

Bibliografisk note

Funding Information:
As part of the NorDigHealth project, the study was funded by the European Regional Development Fund through the Interreg Deutschland-Danmark program (087-1.1-18).

Publisher Copyright:
© 2020 International Institute of Anticancer Research. All rights reserved.

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