Abstract
Background/Aim: Seizures can be the initial symptom of brain metastases. This study investigated pretreatment seizures in patients with a single lesion. Patients and Methods: Pre-operative seizures were analyzed in 104 patients with a single brain metastasis receiving resection plus whole-brain irradiation and a boost. Prevalence of seizures, risk factors and associations with survival (OS) were evaluated. Results: Thirty patients (34.6%) had seizures prior to neurosurgery. Significant associations between seizures and investigated characteristics were not found. However, age =61 years showed a trend (p=0.117) for increased incidence of seizures. Time from diagnosis of malignancy until neurosurgery >12 months was significantly associated with improved OS on univariate analysis (p=0.003). Trends for a positive association with OS were found for no seizures (p=0.054), female gender (p=0.066) and breast cancer (p=0.098). On multivariate analysis, time until neurosurgery >12 months was independently associated (p=0.019) with better OS, and seizures showed a trend (p=0.119) for improved OS. Conclusions: Considering the high prevalence of seizures in this cohort, regular screening and monitoring of these patients appears reasonable. This applies particularly to patients aged ≤61 years.
Originalsprog | Engelsk |
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Tidsskrift | In Vivo |
Vol/bind | 34 |
Udgave nummer | 5 |
Sider (fra-til) | 2705-2709 |
Antal sider | 5 |
ISSN | 0258-851X |
DOI | |
Status | Udgivet - 2020 |
Bibliografisk note
Funding Information:As part of the NorDigHealth project, the study was funded by the European Regional Development Fund through the Interreg Deutschland-Danmark program (087-1.1-18).
Publisher Copyright:
© 2020 International Institute of Anticancer Research. All rights reserved.