TY - JOUR
T1 - PreBötzinger complex and pacemaker neurons: hypothesized site and kernel for respiratory rhythm generation
AU - Rekling, J C
AU - Feldman, J L
N1 - Keywords: Animals; Biological Clocks; Brain Stem; Humans; Neurons; Respiratory Mechanics
PY - 1998
Y1 - 1998
N2 - Identification of the sites and mechanisms underlying the generation of respiratory rhythm is of longstanding interest to physiologists and neurobiologists. Recently, with the development of novel experimental preparations, especially in vitro en bloc and slice preparations of rodent brainstem, progress has been made In particular, a site in the ventrolateral medulla, the preBötzinger Complex, is hypothesized to contain neuronal circuits generating respiratory rhythm. Lesions or disruption of synaptic transmission within the preBötzinger Complex, either in vivo or in vitro, can abolish respiratory activity. Furthermore, the persistence of respiratory rhythm following interference with postsynaptic inhibition and the subsequent discovery of neurons with endogenous bursting properties within the preBötzinger Complex have led to the hypothesis that rhythmogenesis results from synchronized activity of pacemaker or group-pacemaker neurons.
AB - Identification of the sites and mechanisms underlying the generation of respiratory rhythm is of longstanding interest to physiologists and neurobiologists. Recently, with the development of novel experimental preparations, especially in vitro en bloc and slice preparations of rodent brainstem, progress has been made In particular, a site in the ventrolateral medulla, the preBötzinger Complex, is hypothesized to contain neuronal circuits generating respiratory rhythm. Lesions or disruption of synaptic transmission within the preBötzinger Complex, either in vivo or in vitro, can abolish respiratory activity. Furthermore, the persistence of respiratory rhythm following interference with postsynaptic inhibition and the subsequent discovery of neurons with endogenous bursting properties within the preBötzinger Complex have led to the hypothesis that rhythmogenesis results from synchronized activity of pacemaker or group-pacemaker neurons.
U2 - 10.1146/annurev.physiol.60.1.385
DO - 10.1146/annurev.physiol.60.1.385
M3 - Journal article
C2 - 9558470
SN - 0066-4278
VL - 60
SP - 385
EP - 405
JO - Annual Review of Physiology
JF - Annual Review of Physiology
ER -