Preliminary EEG study of protective effects of Tebonin in transient global cerebral ischemia in rats

L Zagrean; R Vatasescu; A M Munteanu; M Moldovan; D A Nita; M Coculescu

Preliminary EEG study of protective effects of Tebonin in transient global cerebral ischemia in rats

L Zagrean, R Vatasescu, A M Munteanu, M Moldovan, D A Nita, M Coculescu

Motor Control

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

3 Citationer (Scopus)

Abstract

Udgivelsesdato: null-null

Originalsprog	Engelsk
Tidsskrift	Romanian Journal of Physiology
Vol/bind	35
Udgave nummer	1-2
Sider (fra-til)	161-8
Antal sider	7
ISSN	1223-4974
Status	Udgivet - 2000

Bibliografisk note

Keywords: Animals; Brain Ischemia; Electroencephalography; Female; Flavonoids; Free Radical Scavengers; Ginkgo biloba; Male; Neuroprotective Agents; Plant Extracts; Platelet Activating Factor; Rats; Rats, Wistar; Reference Values; Reperfusion Injury

Citationsformater

@article{87da2fc0b45411df825b000ea68e967b,

title = "Preliminary EEG study of protective effects of Tebonin in transient global cerebral ischemia in rats",

abstract = "Free radicals and platelet activating factor (PAF) have been implicated as important mediators in neuronal injury after cerebral ischemia-reperfusion and, particularly, in postischemic hypoperfusion. The electroencephalography (EEG) is a real time reflection of changes in neuronal activity and metabolism. The objective of this study was to investigate the effects of preventive treatment with Ginkgo biloba extract (EGb 761--Tebonin) in cerebral global ischemia and reperfusion in rats using computerized EEG analysis. Ginkgo biloba extract, known to be, in vitro, a free radicals scavanger and a PAF--antagonist, was administrated in dose of 100 mg/kg over 24 hours, for 5 days before and 5 days after cerebral ischemia--reperfusion. The apparition of isoelectric EEG (flat-line) following 4-vessel occlusion was observed after a mean time of 25 sec. in Ginkgo biloba treated rats and after 18 sec. in control rats (p < 0.0015). Computerized spectral analysis of EEG has shown that the percentage of slow waves at 10 minutes after reperfusion was 117% higher in control group than in Ginkgo biloba group (p < 0.015) and the percentage of slow waves after 15 minutes of reperfusion was 100% higher in the control group than in the Ginkgo biloba group (p < 0.02). Five days after cerebral ischemia--reperfusion the percentage of slow waves was unsignificantly higher in the control group than in the Ginkgo biloba group (p > 0.05).",

author = "L Zagrean and R Vatasescu and Munteanu, {A M} and M Moldovan and Nita, {D A} and M Coculescu",

note = "Keywords: Animals; Brain Ischemia; Electroencephalography; Female; Flavonoids; Free Radical Scavengers; Ginkgo biloba; Male; Neuroprotective Agents; Plant Extracts; Platelet Activating Factor; Rats; Rats, Wistar; Reference Values; Reperfusion Injury",

year = "2000",

language = "English",

volume = "35",

pages = "161--8",

journal = "Romanian journal of physiology : physiological sciences / [Academia de Stiinte Medicale]",

issn = "1223-4974",

publisher = "EdituraAcademiei Romane",

number = "1-2",

}

TY - JOUR

T1 - Preliminary EEG study of protective effects of Tebonin in transient global cerebral ischemia in rats

AU - Zagrean, L

AU - Vatasescu, R

AU - Munteanu, A M

AU - Moldovan, M

AU - Nita, D A

AU - Coculescu, M

N1 - Keywords: Animals; Brain Ischemia; Electroencephalography; Female; Flavonoids; Free Radical Scavengers; Ginkgo biloba; Male; Neuroprotective Agents; Plant Extracts; Platelet Activating Factor; Rats; Rats, Wistar; Reference Values; Reperfusion Injury

PY - 2000

Y1 - 2000

N2 - Free radicals and platelet activating factor (PAF) have been implicated as important mediators in neuronal injury after cerebral ischemia-reperfusion and, particularly, in postischemic hypoperfusion. The electroencephalography (EEG) is a real time reflection of changes in neuronal activity and metabolism. The objective of this study was to investigate the effects of preventive treatment with Ginkgo biloba extract (EGb 761--Tebonin) in cerebral global ischemia and reperfusion in rats using computerized EEG analysis. Ginkgo biloba extract, known to be, in vitro, a free radicals scavanger and a PAF--antagonist, was administrated in dose of 100 mg/kg over 24 hours, for 5 days before and 5 days after cerebral ischemia--reperfusion. The apparition of isoelectric EEG (flat-line) following 4-vessel occlusion was observed after a mean time of 25 sec. in Ginkgo biloba treated rats and after 18 sec. in control rats (p < 0.0015). Computerized spectral analysis of EEG has shown that the percentage of slow waves at 10 minutes after reperfusion was 117% higher in control group than in Ginkgo biloba group (p < 0.015) and the percentage of slow waves after 15 minutes of reperfusion was 100% higher in the control group than in the Ginkgo biloba group (p < 0.02). Five days after cerebral ischemia--reperfusion the percentage of slow waves was unsignificantly higher in the control group than in the Ginkgo biloba group (p > 0.05).

AB - Free radicals and platelet activating factor (PAF) have been implicated as important mediators in neuronal injury after cerebral ischemia-reperfusion and, particularly, in postischemic hypoperfusion. The electroencephalography (EEG) is a real time reflection of changes in neuronal activity and metabolism. The objective of this study was to investigate the effects of preventive treatment with Ginkgo biloba extract (EGb 761--Tebonin) in cerebral global ischemia and reperfusion in rats using computerized EEG analysis. Ginkgo biloba extract, known to be, in vitro, a free radicals scavanger and a PAF--antagonist, was administrated in dose of 100 mg/kg over 24 hours, for 5 days before and 5 days after cerebral ischemia--reperfusion. The apparition of isoelectric EEG (flat-line) following 4-vessel occlusion was observed after a mean time of 25 sec. in Ginkgo biloba treated rats and after 18 sec. in control rats (p < 0.0015). Computerized spectral analysis of EEG has shown that the percentage of slow waves at 10 minutes after reperfusion was 117% higher in control group than in Ginkgo biloba group (p < 0.015) and the percentage of slow waves after 15 minutes of reperfusion was 100% higher in the control group than in the Ginkgo biloba group (p < 0.02). Five days after cerebral ischemia--reperfusion the percentage of slow waves was unsignificantly higher in the control group than in the Ginkgo biloba group (p > 0.05).

M3 - Journal article

C2 - 11000876

VL - 35

SP - 161

EP - 168

JO - Romanian journal of physiology : physiological sciences / [Academia de Stiinte Medicale]

JF - Romanian journal of physiology : physiological sciences / [Academia de Stiinte Medicale]

SN - 1223-4974

IS - 1-2

ER -